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For many years, it has been known that when rats and mice are given a reduced amount of food, their life span is increased and they remain healthy and vigorous at advanced ages. What is the reason for this change in the usual pattern of aging? The evidence is overwhelming that the life extension results from a slowing of aging processes. And the factor responsible is the decrease in caloric intake. The obvious question: How does this factor work? A good question - and the reason that research on the anti-aging action of caloric restriction is today one of the most studied research areas in

Aging. --- Aging - Nutritional aspects. --- Aging;Nutritional aspects. --- Aging--Nutritional aspects. Low-calorie diet. --- Low-calorie diet. --- Growth and Development --- Diet Therapy --- Energy Intake --- Diet --- Physiological Processes --- Nutrition Therapy --- Caloric Restriction --- Aging --- Therapeutics --- Nutritional Physiological Phenomena --- Physiological Phenomena --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Phenomena and Processes --- Human Anatomy & Physiology --- Health & Biological Sciences --- Physiology --- Nutritional aspects. --- Caloric restriction --- Calorie-restricted diet --- Calorie restriction --- Diet, Low-calorie --- Reducing diets --- Nutrition

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Food or calorie restriction has been shown in many short-lived animals and the rhesus monkey to prolong life-span. Life-long nutrition studies are not possible in humans because of their long survival. Studies over two to six years in healthy adult humans have, however, shown that a 20% reduction in food or calorie intake slows many indices of normal and disease-related aging. Thus, it is widely believed that long-term reduction in calorie or food intake will delay the onset of age-related diseases such as heart disease, diabetes and cancer, and so prolong life. Over the last 20 or more years there has been a progressive rise in food intake in many countries of the world, accompanied by a rising incidence of obesity. Thus our increasing food and calorie intake has been linked to the rising incidence of cardiovascular disease and diabetes in early adult life. It is accepted that overeating, accompanied by reduced physical exercise, will lead to more age-related diseases and shortening of life-span. The answer is to reduce our calorie intake, improve our diet, and exercise more. But calorie restriction is extremely difficult to maintain for long periods. How then can we solve this problem? Edited by a team of highly distinguished academics, this book provides the latest information on the beneficial effects of calorie restriction on health and life-span. This book brings us closer to an understanding at the molecular, cellular and whole organism level of the way forward.

Aging -- Nutritional aspects. --- Longevity -- Nutritional aspects. --- Low-calorie diet. --- Older people -- Nutrition. --- Longevity --- Aging --- Older people --- Low-calorie diet --- Biological Science Disciplines --- Energy Intake --- Physiological Phenomena --- Growth and Development --- Diet Therapy --- Caloric Restriction --- Physiology --- Diet --- Phenomena and Processes --- Natural Science Disciplines --- Nutrition Therapy --- Physiological Processes --- Nutritional Physiological Phenomena --- Disciplines and Occupations --- Therapeutics --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Public Health --- Human Anatomy & Physiology --- Public Health - General --- Health & Biological Sciences --- Nutritional aspects --- Nutrition --- Nutritional aspects. --- Nutrition. --- Caloric restriction --- Calorie-restricted diet --- Calorie restriction --- Diet, Low-calorie --- Medicine. --- Human physiology. --- Geriatrics. --- Oxidative stress. --- Biomedicine. --- Human Physiology. --- Geriatrics/Gerontology. --- Oxidative Stress. --- Reducing diets --- Cytology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Medicine --- Gerontology --- Human biology --- Medical sciences --- Human body --- Diseases --- Health and hygiene --- Oxidation-reduction reaction --- Stress (Physiology)