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"Patterning and Cell Type Specification in the Developing CNS and PNS, Second Edition, the latest release in the Comprehensive Developmental Neuroscience series, presents recent advances in genetic, molecular and cellular methods that have generated a massive increase in new information. The book provides a much-needed update to underscore the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on neural patterning and cell type specification in the developing central and peripheral nervous systems"--
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This enlightening resource takes readers on an informative year-by-year tour of children's brain development from birth through age eight. Each chapter features a collection of developmentally appropriate activities ready for use in classroom or child care settings.
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Developmental neurobiology --- Nerves --- Growth
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This dissertation explores the genetic mechanisms regulating proliferation and cell specification in the Drosophila embryonic central nervous system (CNS). Utilizing the Drosophila model, the research identifies novel genes that influence neural cell specification and progenitor cell behavior. Key findings include the identification of the Ctr9 gene, part of the Paf1 complex, as crucial for CNS development, and the role of the transcription factor worniu in promoting neural proliferation. The study employs forward genetic screens to isolate genes affecting neural proliferation and lineage progression, providing insights relevant to both invertebrate and vertebrate CNS development. The intended audience includes researchers and students in genetics, neurobiology, and developmental biology.
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This thesis by Carina Ulvklo explores the genetic mechanisms controlling cell specification and cell numbers in the Drosophila central nervous system (CNS). It focuses on the role of the neuroblast 5-6 lineage in producing diverse neural cell types and regulating their numbers through combinatorial transcription factor codes. The work investigates the Notch signaling pathway and its components, such as neuralized, kuzbanian, and seven up, which influence the proliferation and differentiation of neural precursors. The study utilizes genetic screening techniques, including FMRFa-GFP transgenic reporter constructs, to identify mutations affecting Apterous neuron development. This research contributes to understanding neural stem cell biology by identifying key regulatory genes and mechanisms that ensure proper neuron subtype specification and cell proliferation timing. It is intended for researchers and professionals in developmental neurobiology and genetics.
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This book focuses on the genetic regulation of central nervous system (CNS) development using the model organism Drosophila melanogaster. It explores how neuroblasts (NBs) divide and differentiate to form the CNS, emphasizing the type I>0 switch in division modes. The research investigates the roles of the Notch pathway and the gene sequoia in regulating this switch, as well as the interplay between early and late factors that control lineage progression. The findings contribute to understanding how precise control of cell proliferation and differentiation is achieved, with implications for diseases like cancer and psychiatric disorders. The book is intended for researchers and students in developmental biology and neuroscience.
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