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The pathomechanisms of allergy are quite well investigated and the disease-causing allergens are characterized in great detail down to their molecular structures. We are thus beginning to see several new strategies for allergen-specific immunotherapy on the horizon, several of which are summarized in this issue. It thus seems that hundred years after the first experimental attempts to “desensitize” hayfever patients we are now capable of developing powerful and rational forms of immunotherapy which hold promise for curing allergy sufferers and eventually may allow real prophylactic vaccination against allergy. It is thus quite possible that allergy may become eradicated similar as certain forms of infectious diseases through vaccination.

Allergy desensitization --- Allergy --- Antigens --- Biological Products --- Immunosuppression --- Investigative Techniques --- Immune System Diseases --- Biological Factors --- Diseases --- Complex Mixtures --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Immunotherapy --- Immunologic Techniques --- Immunomodulation --- Chemicals and Drugs --- Biological Therapy --- Therapeutics --- Desensitization, Immunologic --- Allergens --- Hypersensitivity --- Vaccines --- Methods --- Medicine --- Health & Biological Sciences --- Biology --- Pharmacy, Therapeutics, & Pharmacology --- Clinical Immunology --- Microbiology & Immunology --- Vaccination --- Allergy desensitization. --- Vaccination. --- Allergic diseases --- Allergies --- Hypersensitivity, Immediate --- Immediate allergy --- Immediate hypersensitivity --- Desensitization, Allergy --- Hyposensitization therapy --- Medicine. --- Immunology. --- Vaccines. --- Biomedicine. --- Vaccine. --- Biologicals --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- Immunization --- Immunologic diseases --- Immunoglobulin E