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This unique volume presents an up-to-date review of one of the world's major health problems - diseases caused by the four dengue viruses. It begins with an insightful story of the origin of dengue disease outbreaks, including the emergence of severe and fatal dengue hemorrhagic fever. The nature, structure and biology of the four dengue viruses are described, and a major portion of the book is focused on the epidemiology of dengue as a mosquito-borne disease. This is complemented by critiques of existing mosquito control programs by three groups of outstanding authorities. The strongest element of the volume is its comprehensive description of the current understanding of dengue disease pathogenesis, followed by an analysis of the pros and cons of five of the most controversial areas in the field: the WHO DEF case definition, secondary dengue infections, virulent viruses, the role of abnormal T cells and autoimmunity.

Dengue. --- Dengue viruses. --- Flaviviruses --- Breakbone fever --- Dengue fever --- Arbovirus infections --- Flaviviral diseases --- Hemorrhagic fever

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Dengue is the most important mosquito-transmitted viral disease in humans. Half of the world population is at risk of infection, mostly in tropical and sub-tropical areas. The World Health Organization (WHO) estimates that 50 to 100 million infections occur yearly, with 50,000 to 100,000 deaths related to dengue, mainly in children. Recent estimates show higher numbers, up to three times more, with 390 million estimated dengue infections per year, among which 96 million apparent infections (Bhatt et al. 2013). Initially localized to South-East Asia, dengue virus (DENV) started its spread in Latin America in the 80s. Little is known about DENV spread in Africa, but multiple seroprevalence surveys over several years are now clearly showing endemic areas in East and West Africa (Brady et al. 2013). Finally, due to global warming and intense traveling there is a risk of global spread towards more temperate regions, and both US Key islands (FL) and southern Europe recently faced DENV outbreaks. There are currently no specific treatments or vaccines available. Even though several dengue vaccines are in the pipeline, clear correlates of protection are still lacking. The recent failure of the live-attenuated Sanofi vaccine Phase 2b trial (Sabchareon et al. 2013) and the lack of correlation between clinical protection and in vitro neutralization assays, clearly underlines the necessity to better understand the role of the different components of the immune system in protection against dengue virus infection and the requirement for the development of additional and/or improved predictive assays. The aim of this research topic is to provide novel data, opinions and literature reviews on the best immune correlates of protection and recent advances in the immune response to DENV infection that can allow rapid progress of dengue vaccines. Authors can choose to submit original research papers, reviews or opinions on pre-clinical or clinical observations that will help unify the field, with perspectives from epidemiology, virology, immunology and vaccine developers. This research topic will discuss different aspects of the protective immune response to DENV that can influence vaccine development. It will include a review of epidemiological data generated in the field, which will address spatio-temporal diversity of DENV epidemics, the importance of cross-reactive protection and of the time-interval between infections as a predictor of disease. It will further include a review of the role of both the innate and adaptive immunity in DENV infection control, and discuss the usefulness of new improved animal models in dissecting the role of each immunological compartment, which will help define new correlate of immune protection. New data concerning the DENV structure and anti-dengue antibody structure will address the necessity of improved neutralization assays. The ultimate test to prove vaccine efficacy and study immune correlates of protection in humans before large trials will open up the discussion on human DENV challenges using controlled attenuated viral strains. Finally, the role of vaccines, administered in flavi-immune populations, in the modification of future epidemics will also be approached and will include novel studies on mosquitoes infection thresholds.

Dengue viruses. --- Vaccines. --- Monocytes --- NK cells --- Dendritic Cells --- Dengue --- Antibodies --- protection --- Vaccines --- T cells --- Macrophages --- Immunity

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Scientific research on dengue has a long and rich history. The literature has been touched by famous names in medicine- Benjamin Rush, Walter Reed, and Albert Sabin, to name a very few- and has been fertile ground for medical historians . The advances made in those early investigations are all the more remarkable for the limited tools available at the time. The demonstration of a viral etiology for dengue fever, the recognition of mosquitoes as the vector for transmission to humans, and the existence of multiple viral variants (serotypes) with only partial cross-protection were all accomplished prior to the ability to culture and characterize the etiologic agent. Research on dengue in this period was typically driven by circumstances. Epidemics of dengue created public health crises, although these were relatively short-lived in any one location, as the population of susceptible individuals quickly shrank. Military considerations became as a major driving force for research. With the introduction of large numbers of non-immune individuals into endemic areas, dengue could cripple military readiness, taking more soldiers out of action than hostile fire. Dengue and dengue hemorrhagic fever, which assumed pandemic proportions during the latter half of the last century, have shown no indication of slowing their growth during this first decade of the twenty-first century. Challenges remain in understanding the basic mechanisms of viral replication and disease pathogenesis, in clinical management of patients, and in control of dengue viral transmission. Nevertheless, new tools and insights have led to major recent scientific advances. As the first candidate vaccines enter large-scale efficacy trials, there is reason to hope that we may soon "turn the corner" on this disease.

Dengue. --- Dengue viruses. --- Dengue --- Dengue viruses --- Dengue Virus --- Virology --- Flavivirus --- Microbiology --- Flavivirus Infections --- Arbovirus Infections --- Hemorrhagic Fevers, Viral --- Virus Diseases --- Biology --- Flaviviridae Infections --- Flaviviridae --- RNA Virus Infections --- RNA Viruses --- Biological Science Disciplines --- Diseases --- Viruses --- Natural Science Disciplines --- Vertebrate Viruses --- Disciplines and Occupations --- Organisms --- Communicable Diseases --- Microbiology & Immunology --- Infectious Diseases --- Medicine --- Public Health --- Health & Biological Sciences --- Breakbone fever --- Dengue fever --- Medicine. --- Immunology. --- Virology. --- Biomedicine. --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- Arbovirus infections --- Flaviviral diseases --- Hemorrhagic fever --- Flaviviruses --- Medical virology. --- Medical microbiology --- Virus diseases

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Dengue fever is the world's most prevalent mosquito-borne illness, but Alex Nading argues that people in dengue-endemic communities do not always view humans and mosquitoes as mortal enemies. Drawing on two years of ethnographic research in urban Nicaragua and challenging current global health approaches to animal-borne illness, Mosquito Trails tells the story of a group of community health workers who struggle to come to terms with dengue epidemics amid poverty, political change, and economic upheaval. Blending theory from medical anthropology, political ecology, and science and technology studies, Nading develops the concept of "the politics of entanglement" to describe how Nicaraguans strive to remain alive to the world around them despite global health strategies that seek to insulate them from their environments. This innovative ethnography illustrates the continued significance of local environmental histories, politics, and household dynamics to the making and unmaking of a global pandemic.

Dengue --- Dengue. --- Politics. --- Health Knowledge, Attitudes, Practice . --- Environmental Health. --- Breakbone fever --- Dengue fever --- Arbovirus infections --- Flaviviral diseases --- Hemorrhagic fever --- Environmental Health Science --- Health, Environmental --- Environmental Health Sciences --- Environmental Healths --- Health Science, Environmental --- Health Sciences, Environmental --- Healths, Environmental --- Science, Environmental Health --- Sciences, Environmental Health --- Ecology --- Knowledge, Attitudes, Practice --- Conservatism --- Decentralization --- Liberalism --- Political Factors --- Voting --- Political Activity --- Activities, Political --- Activity, Political --- Factor, Political --- Factors, Political --- Political Activities --- Political Factor --- Dissent and Disputes --- Break-Bone Fever --- Breakbone Fever --- Classical Dengue --- Classical Dengue Fever --- Dengue Fever --- Break Bone Fever --- Classical Dengue Fevers --- Classical Dengues --- Dengue Fever, Classical --- Dengue, Classical --- Fever, Break-Bone --- Fever, Breakbone --- Fever, Dengue --- Nicaragua. --- Nikaragua --- Nikaragoua --- República de Nicaragua --- Republic of Nicaragua --- Central America (Federal Republic) --- Environmental Health --- Health Knowledge, Attitudes, Practice --- Politics --- #SBIB:39A4 --- #SBIB:39A9 --- #SBIB:39A74 --- #SBIB:327.4H63 --- Toegepaste antropologie --- Medische antropologie / gezondheid / handicaps --- Etnografie: Amerika --- Derde wereld: ontwikkelingspolitiek, hervormingen (binnenlands, onderwijs-, gezondheidsbeleid e.a.) --- Dengue viruses. --- Flaviviruses --- animal borne illness. --- community health workers. --- dengue endemic communities. --- dengue fever. --- dengue virus. --- diagnosis. --- disease. --- economic change. --- ethnographic research. --- experiments. --- fever. --- global health. --- global pandemic. --- health care. --- high fever. --- illness. --- medical anthropology. --- medical conditions. --- medical. --- mosquito borne disease. --- mosquito. --- political change. --- political ecology. --- poverty. --- science and math. --- science. --- skin rash. --- technology. --- the politics of entanglement. --- theoretical. --- tropical disease. --- urban nicaragua. --- virus.

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Zika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family that historically has been associated with mild febrile illness. However, the recent outbreaks in Brazil in 2015 and its rapid spread throughout South and Central America and the Caribbean, together with its association with severe neurological disorders—including fetal microcephaly and Guillain-Barré syndrome in adults—have changed the historic perspective of ZIKV. Currently, ZIKV is considered an important public health concern that has the potential to affect millions of people worldwide. The significance of ZIKV in human health and the lack of approved vaccines and/or antiviral drugs to combat ZIKV infection have triggered a global effort to develop effective countermeasures to prevent and/or treat ZIKV infection. In this Special Issue of Viruses, we have assembled a collection of 32 research and review articles that cover the more recent advances on ZIKV molecular biology, replication and transmission, virus–host interactions, pathogenesis, epidemiology, vaccine development, antivirals, and viral diagnosis.

microRNAs --- antivirals --- reverse genetics --- nucleic acid computation --- viral pathogenesis --- plaque reduction neutralization test --- clinical trials --- viral genetic variation --- viral fitness --- pregnancy --- type I IFN antagonist --- prM-E proteins --- eye --- replicon --- antiviral responses --- Bacterial artificial chromosome --- gene expression --- NS1 protein --- viral permissiveness --- ZIKV–host interactions --- reporter virus --- viral persistence --- blood-retinal barrier --- virus like particles --- emerging arbovirus --- Non-human primates --- heme-oxygenase 1 --- mosquito surveillance --- antiviral compounds --- ZIKV-associated neurologic disorders --- external quality assessment --- outbreak control --- therapeutics --- cryptic promoter silencing --- testis --- neurons --- mutagenesis --- RNA-seq --- microsphere immunoassay --- host-directed antivirals --- molecular diagnostics --- Bayesian analyses --- astrocytomas --- Full-length cDNA infectious clones --- viral pathogenicity --- neural progenitor cells --- full-length molecular clone --- antiviral --- multiplex nucleic acid detection --- Asian-lineage --- nucleic acid strand exchange --- IgA --- African-lineage --- vaccines --- Zika --- research models and tools --- immune response --- IgG avidity tests --- polymerase chain reaction --- Asian lineage --- sexual transmission --- TLR7/8 --- neuropathogenesis --- cross-reactions --- genetic variability --- mosquito --- ZIKV --- infectious cDNA --- prostate --- host genetic variation --- monoclonal antibodies --- optimised --- anti-viral immunity --- QCMD --- arbovirus --- FSS13025 --- MR766 --- NS5 --- EQA --- testicular cells --- virus attachment --- flavivirus --- mosquito-borne flavivirus --- dsRNA --- boolean logic-processing nucleic acid probes --- Ziks virus --- viral replication --- Aedes aegypti --- infection --- natural history --- infectious RNA --- zika virus --- chimeric viruses --- subgenomic replicon --- replication --- human brain glial cells --- microglia cells --- hepatocytes --- bacterial artificial chromosome --- detoxification and immune system responses --- testes --- dengue viruses --- Zika virus --- insecticide resistance --- NS2A protein --- plasmid toxicity --- cell surface receptors --- serology --- viral evolution --- laboratory preparedness --- flaviviruses --- Tet-inducible --- dengue virus --- diagnosis --- assay standardization --- infectious clone --- ELISA --- innate response --- congenital Zika syndrome --- secondary infections --- apoptosis --- viral survival --- ocular --- validated --- rhesus macaques --- neuroinflammation --- placenta cells --- NHP --- Zika virus (ZIKV) --- point-of-care diagnostics --- isothermal nucleic acid amplification --- microcephaly --- cytopathic effects --- indirect immunofluorescence --- fetal infection --- therapy --- siRNA --- viral counteraction --- neural cells --- silvestrol --- eIF4A