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In this edited volume, experts on the treatment of dementia associated with Parkinson's Disease (PD) describe in detail the current status of knowledge in their respective area of expertise. The importance and clinical relevance of cognitive impairment and dementia in PD is emphasized, all relevant aspects including epidemiology, full and detailed spectrum of clinical features, current knowledge on pathology, neurochemistry and genetics, findings in auxiliary investigations, relation to other neurodegenerative disorders, diagnostic process and management are described, rounded-up by discussion
Parkinson's disease. --- Lewy body dementia. --- Dementia with Lewy bodies --- DLB (Dementia with Lewy bodies) --- LBD (Lewy body dementia) --- Dementia --- Palsy, Shaking --- Paralysis agitans --- Parkinson disease --- Parkinsonism --- Shaking palsy --- Brain --- Extrapyramidal disorders --- Diseases
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The range of human neurodegenerative diseases continues to pose significant unmet medical needs for societies around the world. The progressive and terminal nature of these conditions places a considerable personal burden on the individual affected but also on public health systems and health services. Tens of millions of people are indiscriminately affected by various dementias, which are rising at an alarming rate. There are no cures for many conditions, and it is clear that treatments applied as early as possible could greatly improve outcomes for patients. Therefore, new disease classification and diagnostic tools should be a key priority. Metabolomics represents a relatively new field of analytical science, which can be extremely useful in the early diagnosis of disease. The relatively unique feature of metabolites is that they sit at the intersection between the genetic background of an organism and its environment. Because many neurodegenerative diseases are not genetically inherited (instead having a range of known genetic risk factors and also a large number of unknown environmental triggers) the field of metabolomics offers great promise for the discovery of new, biologically, and clinically relevant biomarkers for neurodegenerative disorders. It is already bringing forward new knowledge in terms of the mechanisms of neurodegenerative disease.
glutamic acid --- n/a --- direct mass spectrometry --- neurodegeneration --- 6-OHDA --- targeted mass spectrometry --- mitochondrial dysfunction --- myo-inositol --- metabolomics --- bile acids --- subacute mild traumatic brain injury --- age-related macular degeneration --- metabolic pathways --- energy metabolism --- midbrain --- Alzheimer’s disease --- biomarkers --- 1H NMR --- Parkinson’s disease dementia --- GC-MS --- pathogenesis --- tricarboxylic acid cycle --- micro-dialysis --- 13C-labeled succinate --- metabolism --- lipidomics --- dementia with Lewy bodies --- fatty acid --- prodromal Parkinson’s disease --- malonate --- cerebral ischemia --- mass spectrometry --- retinal pigment epithelium --- excitotoxicity --- endothelin-1 --- reperfusion --- C. elegans --- Streptomyces venezuelae --- ?-synuclein aggregates --- natural product --- fatty acid metabolism --- imaging mass spectrometry --- LC-MS --- drusen --- cerebral palsy --- plasma --- Parkinson’s disease --- Alzheimer's disease --- Parkinson's disease dementia --- prodromal Parkinson's disease --- Parkinson's disease
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A fun and fact-filled A-Z treasury for anyone with a head on their shoulders, Neuropedia journeys into the mysteries and marvels of the three pounds of tissue between your ears—the brain. Eric Chudler takes you on a breathtaking tour of the nervous system with dozens of entries that explore the structure and function of the brain and cover topics such as the spinal cord and nerve cells, the methods of neuroscientific research, and the visionary scientists who have dedicated their lives to understanding what makes each of us who we are. The brain has fascinated and puzzled researchers, physicians, and philosophers for thousands of years and captivated us with each new discovery. This compendium of neuroscientific wonders is brimming with facts and insights, helping us to make sense of our current understanding of the nervous system while identifying the frontiers in our knowledge that remain unexplored. Chudler guides readers through a variety of rare and common neurological disorders such as alien hand disorder, Capgras syndrome, Alzheimer’s disease, Parkinson’s disease, and stroke, and discusses the latest brain-imaging methods used to diagnose them. He discusses neurochemicals, neurotoxins, and lifesaving drugs, and offers bold perspectives on human consciousness that enable us to better appreciate our place in nature. With marvelous illustrations by Kelly Chudler, Neuropedia is an informative and entertaining trip into the inner world of the brain.
Brain. --- Brain --- Brain --- Acetylcholine receptor. --- Acetylcholine. --- Action potential. --- Addiction. --- Agenesis of the corpus callosum. --- Alien hand syndrome. --- Alzheimer's disease. --- Amnesia. --- Amphibian. --- Anger. --- Anterior cerebral artery. --- Anxiolytic. --- Arachnoid mater. --- Astrocyte. --- Attention deficit hyperactivity disorder. --- Axon terminal. --- Axon. --- Blood vessel. --- Blood-brain barrier. --- Brain damage. --- Brain injury. --- CT scan. --- Catalepsy. --- Cerebellum. --- Cerebral cortex. --- Cerebrospinal fluid. --- Chemical synapse. --- Cocaine. --- Coronavirus. --- Covid-19. --- Cranial nerves. --- Delicacy. --- Dementia with Lewy bodies. --- Dendrite. --- Dextroamphetamine. --- Dopamine. --- Dura mater. --- Electrode. --- Electroencephalography. --- Epilepsy. --- Eye movement. --- Gamma-Aminobutyric acid. --- Headache. --- Hormone. --- Human brain. --- Hypothalamus. --- Insecticide. --- Ion channel. --- James W. Watts. --- L-DOPA. --- Lewy body. --- Local anesthetic. --- MDMA. --- Meningitis. --- Muscle. --- Narcolepsy. --- Nerve agent. --- Neural development. --- Neurological disorder. --- Neuron. --- Neuroscientist. --- Neurotransmitter. --- Nicotinic acetylcholine receptor. --- Node of Ranvier. --- On Intelligence. --- Oval window. --- Panaeolus. --- Parietal lobe. --- Parkinson's disease. --- Pathology. --- Peripheral nervous system. --- Posterior cerebral artery. --- Princeton University. --- Prosopagnosia. --- Psychology. --- Radio frequency. --- Rapid eye movement sleep. --- Receptor (biochemistry). --- Riluzole. --- Rosemary Kennedy. --- Schizophrenia. --- Scientist. --- Serotonin. --- Short-term memory. --- Sleep disorder. --- Sodium. --- Spatial memory. --- Spina bifida. --- Spinal cord. --- Stimulant. --- Symptom. --- Syndrome. --- Temporal lobe. --- The Canon of Medicine. --- Toothpaste. --- Tourette syndrome. --- Ventricular system. --- Visual Objects. --- Vomiting. --- Wernicke's encephalopathy. --- Anatomy. --- Physiology. --- Acetylcholine receptor. --- Acetylcholine. --- Action potential. --- Addiction. --- Agenesis of the corpus callosum. --- Alien hand syndrome. --- Alzheimer's disease. --- Amnesia. --- Amphibian. --- Anger. --- Anterior cerebral artery. --- Anxiolytic. --- Arachnoid mater. --- Astrocyte. --- Attention deficit hyperactivity disorder. --- Axon terminal. --- Axon. --- Blood vessel. --- Blood-brain barrier. --- Brain damage. --- Brain injury. --- CT scan. --- Catalepsy. --- Cerebellum. --- Cerebral cortex. --- Cerebrospinal fluid. --- Chemical synapse. --- Cocaine. --- Coronavirus. --- Covid-19. --- Cranial nerves. --- Delicacy. --- Dementia with Lewy bodies. --- Dendrite. --- Dextroamphetamine. --- Dopamine. --- Dura mater. --- Electrode. --- Electroencephalography. --- Epilepsy. --- Eye movement. --- Gamma-Aminobutyric acid. --- Headache. --- Hormone. --- Human brain. --- Hypothalamus. --- Insecticide. --- Ion channel. --- James W. Watts. --- L-DOPA. --- Lewy body. --- Local anesthetic. --- MDMA. --- Meningitis. --- Muscle. --- Narcolepsy. --- Nerve agent. --- Neural development. --- Neurological disorder. --- Neuron. --- Neuroscientist. --- Neurotransmitter. --- Nicotinic acetylcholine receptor. --- Node of Ranvier. --- On Intelligence. --- Oval window. --- Panaeolus. --- Parietal lobe. --- Parkinson's disease. --- Pathology. --- Peripheral nervous system. --- Posterior cerebral artery. --- Princeton University. --- Prosopagnosia. --- Psychology. --- Radio frequency. --- Rapid eye movement sleep. --- Receptor (biochemistry). --- Riluzole. --- Rosemary Kennedy. --- Schizophrenia. --- Scientist. --- Serotonin. --- Short-term memory. --- Sleep disorder. --- Sodium. --- Spatial memory. --- Spina bifida. --- Spinal cord. --- Stimulant. --- Symptom. --- Syndrome. --- Temporal lobe. --- The Canon of Medicine. --- Toothpaste. --- Tourette syndrome. --- Ventricular system. --- Visual Objects. --- Vomiting. --- Wernicke's encephalopathy.
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