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Drug delivery systems. --- Drug Delivery Systems.

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Asthma is a chronic disease of the airways. Its frequency and severity vary greatly from one person to another. This disease is defined by repetitive crises manifested by breathing difficulties and wheezing. In a crisis, the bronchial wall becomes inflamed and swells, causing a significant decrease in bronchia l diameter and therefore reduces the air flow both inhaled and exhaled.The management of asthma patients based on both non-pharmacological advice as well as customized and adequate drug treatment. These will most often inhaled medicines, developed by numerous studies before being placed on the market, targeting the distal airways.What do we mean by that? What about effectiveness? Superfine particles, what does that mean?Here are some questions that this memory will attempt to provide answers: analyzing pathology, based on the pharmacological properties of treatments and clinical studies. L'asthme est une maladie chronique des voies respiratoires . Sa fréquence et sa gravité varient très fortement d'une personne à l'autre. Cette maladie se définit par des crises répétitives se manifestant par des difficultés respiratoires et une respiration sifflante. En cas de crise, la paroi des bronches s'enflamme et gonfle, entraînant une importante diminution du diamètre bronchique et réduit par conséquent le débit d'air inspiré et expiré.La prise en charge des patients asthmatiques se base à la fois sur des conseils non pharmacologiques ainsi que sur des traitements médicamenteux personnalisés et adéquats. Ceux-ci seront le plus souvent des médicaments à inhaler, mis au point par de nombreuses études pharmaceutiques avant leur mise sur le marché, et ayant comme caractéristique la capacité de cibler les voies aériennes distales.Qu'entendons-nous par-là ? Qu'en est-il de leur efficacité ? Particules extrafines, qu'est-ce que cela signifie ? Voici des questions auxquelles ce mémoire va tenter d'apporter des réponses : en analysant la pathologie, en se basant sur les propriétés pharmacologiques des traitements et sur les études cliniques.

Asthma --- Drug Delivery Systems

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Nano- or micro-encapsulation is used in many different fields and industries, including pharmaceuticals, cosmetics, food, and agrochemicals. It offers advantages for various applications, especially drug delivery. Nano-encapsulation can help extend and control the release of drugs as well as increase drug bioavailability and efficacy. It improves the precision of targeted drug delivery and allows for fabricating nano-encapsulated drugs for diagnostic and theranaostic applications. This book covers recent advances in fabricating nano-/micro-capsules using natural carriers for therapeutic and diagnostic drug delivery applications as well as rheology and formulations of micro-emulsions for diverse applications. This book is essential for scientists and researchers with diverse backgrounds in chemistry, engineering, material sciences, pharmaceuticals, and drug delivery.

Drug delivery systems.

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Crystal engineering is a broad area of research that includes crystal habit modification, polymorphism, solid dispersions, and salt formation. This reprint covers state-of-the-art applications of crystal engineering and includes a combination of research and review articles, with special emphasis on novel drug delivery and targeting applications.

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Conventional ophthalmic formulations lack prolonged drug release effects and mucoadhesive properties, decreasing their residence time in the precorneal area and, therefore, in drug penetration across ocular tissues, presenting a low bioavailability with a consequent reduction in the therapeutic efficacy. These limitations are related to the physiological mechanisms of the eye, for example, the diluting effect of formulations exerted by the tear fluid, constant turnover of the tear fluid, blink reflex, limited capacity of the conjunctival sac, and drainage of formulations applied by gravity.

Drug delivery systems. --- Nanoparticles.