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Nucleic acid --- DNA-ligand interactions. --- DNA-protein interactions. --- Interactions ADN-ligand --- Structure. --- -DNA-ligand interactions --- DNA-protein interactions --- DNA-protein binding --- Interactions, DNA-protein --- Protein-DNA interactions --- DNA-ligand interactions --- Protein binding --- Binding, DNA-ligand --- DNA-ligand binding --- Interactions, DNA-ligand --- Ligand binding (Biochemistry) --- Structure

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DNA-protein interactions --- DNA-Binding Proteins --- Protein Binding --- Research --- Methodology --- laboratory manuals --- 57.088.6 --- DNA-protein binding --- Interactions, DNA-protein --- Protein-DNA interactions --- DNA-ligand interactions --- Protein binding --- Methodology. --- Methods and techniques for studying metabolism and biotransformation.Radioisotopes methods and techniques. --- DNA-BINDING PROTEINS, laboratory manuals --- PROTEIN BINDING, laboratory manuals --- DNA-BINDING PROTEINS, laboratory manuals. --- PROTEIN BINDING, laboratory manuals. --- 57.088.6 Methods and techniques for studying metabolism and biotransformation.Radioisotopes methods and techniques. --- Dna-binding proteins, laboratory manuals. --- Dna-protein interactions --- Protein binding, laboratory manuals. --- Research&delete& --- Methods and techniques for studying metabolism and biotransformation.Radioisotopes methods and techniques --- laboratory manuals.

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In recent years, a number of groundbreaking structural and mechanistic studies deepened our understanding of helicase mechanisms and established new approaches for their analyses. Many fundamental mechanistic questions ranging from the mechanism of force generation, mechanochemical coupling to distinct mechanisms by which the same enzyme translocates on DNA removing obstacles, unwinds DNA and/or remodels nucleoprotein complexes, however, remain to be answered. It is even less understood how the helicase motors are incorporated into a wide range of genome maintenance and repair machines. The field has reached a stage when the studies of molecular mechanisms and basic biology of helicases can and shall be integrated with the studies of development, cancer and longevity. The objective of this book is to provide the first systematic overview of structure, function and regulation of DNA helicases and related molecular motors. By integrating the knowledge obtained through the diverse technical approaches ranging from single-molecule biophysics to cellular and molecular biological studies the editors aim to provide a unified view on how helicases function in the cell, are regulated in response to different cellular stresses and are integrated into large macromolecular assemblies to form a complex and adaptive living system.

Bacterial genetics. --- DNA helicases. --- DNA polymerases. --- Isomerases --- Adenosine Triphosphatases --- Multiprotein Complexes --- Acid Anhydride Hydrolases --- Enzymes --- Macromolecular Substances --- Enzymes and Coenzymes --- Hydrolases --- Chemicals and Drugs --- Molecular Motor Proteins --- DNA Helicases --- Medicine --- Human Anatomy & Physiology --- Biology --- Health & Biological Sciences --- Animal Biochemistry --- Genetics --- Pathology --- DNA-protein interactions. --- DNA-protein binding --- Interactions, DNA-protein --- Protein-DNA interactions --- Helicases, DNA --- Medicine. --- Human genetics. --- Biochemistry. --- Cell biology. --- Biomedicine. --- Human Genetics. --- Biochemistry, general. --- Cell Biology. --- Biomedicine general. --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Heredity, Human --- Human biology --- Physical anthropology --- Clinical sciences --- Medical profession --- Life sciences --- Physicians --- Composition --- DNA-ligand interactions --- Protein binding --- Cytology. --- Health Workforce --- Biomedicine, general.

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This book presents a concise overview of current research on the biophysics of DNA-protein interactions. A wide range of new and classical methods are presented by authors investigating physical mechanisms by which proteins interact with DNA. For example, several chapters address the mechanisms by which proteins search for and recognize specific binding sites on DNA, a process critical for cellular function. Single molecule methods such as force spectroscopy as well as fluorescence imaging and tracking are described in these chapters as well as other parts of the book that address the dynamics of protein-DNA interactions. Other important topics include the mechanisms by which proteins engage DNA sequences and/or alter DNA structure. These simple but important model interactions are then placed in the broader biological context with discussion of larger protein-DNA complexes . Topics include replication forks, recombination complexes, DNA repair interactions, and ultimately, methods to understand the chromatin context of the cell nucleus. This book will be of interest to readers who wish to explore current biophysical approaches to DNA-protein interactions across multiple levels of biological complexity.

DNA-protein interactions. --- DNA-protein interactions --- Molecular biology --- Physical Phenomena --- Proteins --- Phenomena and Processes --- Amino Acids, Peptides, and Proteins --- DNA-Binding Proteins --- Biophysical Phenomena --- Chemicals and Drugs --- Human Anatomy & Physiology --- Biology --- Health & Biological Sciences --- Animal Biochemistry --- Biophysics --- Molecular biology. --- Molecular biochemistry --- Molecular biophysics --- DNA-protein binding --- Interactions, DNA-protein --- Protein-DNA interactions --- Physics. --- Biochemistry. --- Proteins. --- Cell biology. --- Biophysics. --- Biological physics. --- Biomedical engineering. --- Biophysics and Biological Physics. --- Molecular Medicine. --- Cell Biology. --- Biomedical Engineering. --- Biochemistry, general. --- Protein Structure. --- Biochemistry --- Biomolecules --- Systems biology --- DNA-ligand interactions --- Protein binding --- Medicine. --- Cytology. --- Biological and Medical Physics, Biophysics. --- Biomedical Engineering and Bioengineering. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Clinical engineering --- Medical engineering --- Bioengineering --- Engineering --- Medicine --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Composition --- Health Workforce --- Proteins . --- Proteids --- Polypeptides --- Proteomics --- Biological physics --- Physics

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Nucleic acids --- Proteins --- Enzymes --- Physical biochemistry --- Macromolecules --- Ligand binding (Biochemistry) --- Protein folding --- Polypeptides --- Nucleic acid hybridization --- Catalysis --- DNA --- DNA-protein interactions --- RNA --- RNA-protein interactions --- Nucleic Acids --- 577.122 --- Gene Products, Protein --- Gene Proteins --- Protein --- Protein Gene Products --- Proteins, Gene --- Molecular Mechanisms of Pharmacological Action --- 577.122 Protein metabolism --- Protein metabolism --- Nucleic Acid --- Acid, Nucleic --- Acids, Nucleic --- Interactions, RNA-protein --- Protein-RNA interactions --- RNA-protein binding --- Protein binding --- Ribonucleic acid --- Ribose nucleic acid --- Ribose --- DNA-protein binding --- Interactions, DNA-protein --- Protein-DNA interactions --- DNA-ligand interactions --- Deoxyribonucleic acid --- Desoxyribonucleic acid --- Thymonucleic acid --- TNA (Nucleic acid) --- Deoxyribose --- Genes --- Activation (Chemistry) --- Chemistry, Physical and theoretical --- Surface chemistry --- Enzyme regulation --- Regulation of enzyme activity --- Biological control systems --- Cytogenetics --- Cytology --- Hybridization --- Polynucleotides --- Biomolecules --- Biopolymers --- Peptides --- Denaturation of proteins --- Protein denaturation --- Protein unfolding --- Unfolding of proteins --- Coagulation --- Folding of proteins --- Protein conformation --- Biocatalysts --- Ferments --- Soluble ferments --- Catalysts --- Enzymology --- Binding, Ligand (Biochemistry) --- Biochemistry --- Dye-ligand affinity chromatography --- Radioligand assay --- Molecules --- Supramolecular chemistry --- Biophysical chemistry --- Physical organic chemistry --- Proteids --- Proteomics --- Conformation --- Denaturation --- Structure --- Regulation --- Technique --- Unfolding --- Folding