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Visualizing chemical components in a specimen is an essential technology in many branches of science and practical applications. This book deals with electrochemical imaging techniques based on semiconductor devices with capability of spatially resolved sensing. Two types of such sensing devices have been extensively studied and applied in various fields, i.e., arrayed sensors and light-addressed sensors. An ion-sensitive field-effect transistor (ISFET) array and a charge-coupled device (CCD) ion image sensor are examples of arrayed sensors. They take advantage of semiconductor microfabrication technology to integrate a large number of sensing elements on a single chip, each representing a pixel to form a chemical image. A light-addressable potentiometric sensor (LAPS), on the other hand, has no pixel structure. A chemical image is obtained by raster-scanning the sensor plate with a light beam, which can flexibly define the position and size of a pixel. This light-addressing approach is further applied in other LAPS-inspired methods. Scanning photo-induced impedance microscopy (SPIM) realized impedance mapping and light-addressable electrodes/light-activated electrochemistry (LAE) realized local activation of Faradaic processes. This book includes eight articles on state-of-the-art technologies of light-addressing/chemical imaging devices and their application to biology and materials science.

CCD ion sensor --- multi-ion image --- CMOS technology --- ink-jet printing --- bioactive cations --- LAPS --- chemical imaging --- spatial and temporal resolution --- semiconductor --- microfluidics --- photoelectrochemistry --- InGaN/GaN epilayer --- cell imaging --- light-activated electrochemistry --- light-addressable potentiometric sensor --- chemical imaging sensor --- field-effect sensor --- light-addressable potentiometric sensor (LAPS) --- Lactobacillus brevis --- Escherichia coli --- Corynebacterium glutamicum --- cellular metabolism --- differential cell-based measurement --- multi-analyte analysis --- extracellular acidification --- DNA biosensor --- ZnO nanorod arrays --- label-free detection --- E. coli --- light-addressable electrode --- light-addressable cell stimulation and photoelectrochemistry --- photoelectrochemical deposition --- crevice corrosion --- potential distribution --- crevice gap

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The high importance of free radical chemistry for a variety of biological events, including ageing and inflammation, has attracted considerable interest in understanding the related mechanistic steps at the molecular level. Modelling the free radical chemical reactivity of biological systems is an important research area. When studying free-radical-based chemical mechanisms, biomimetic chemistry and the design of established biomimetic models come into play to perform experiments in a controlled environment, suitably designed to be a similar as possible to cellular conditions. This Special Issue provides readers with a wide overview of biomimetic radical chemistry, where molecular mechanisms have been defined and molecular libraries of products are developed to be used as traces for the discoveries of some relevant biological processes. Several subjects are presented, with five articles and five reviews written by specialists in the fields of DNA, proteins, lipids, biotechnological applications and bioinspired synthesis, with “free radicals” as the common denominator.

guanine --- guanyl radical --- tautomerism --- guanine radical cation --- oligonucleotides --- DNA --- G-quadruplex --- time-resolved spectroscopies --- reactive oxygen species (ROS) --- oxidation --- catalase mimics --- peroxide --- diiron-peroxo complexes --- structure/activity --- kinetic studies --- biomimetic chemistry --- cysteine --- ketone reduction --- free radicals --- pulse radiolysis --- kinetics --- DNA oxidation --- DNA hole transfer --- molecular dynamics --- quantum dynamics --- electron transfer --- charge transfer --- quantum coherence --- chemiluminescence --- reaction mechanisms --- singlet oxygen --- reactive oxygen species --- light emission --- crosslink --- dimerization --- protein oxidation --- radicals --- di-tyrosine --- di-tryptophan --- disulfides --- thiols --- aggregation --- proteomics --- mass spectrometry --- collagen --- riboflavin --- hyaluronic acid --- EPR spectroscopy --- keratoconus --- STEM --- DNA biosensor --- chemical nucleases --- DNA-drug interaction --- copper complexes --- metallodrugs --- MEP pathway --- antibiotics --- IspH --- LytB --- [4Fe-4S] cluster --- reductive dehydroxylation --- bioorganometallic intermediate --- inhibitors --- methionine --- neighboring group effect --- hydroxyl radical --- triplet state of carboxybenzophenone --- one-electron oxidants --- laser flash photolysis --- peptides --- proteins --- n/a

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The present book is devoted to all aspects of biosensing in a very broad definition, including, but not limited to, biomolecular composition used in biosensors (e.g., biocatalytic enzymes, DNAzymes, abiotic nanospecies with biocatalytic features, bioreceptors, DNA/RNA, aptasensors, etc.), physical signal transduction mechanisms (e.g., electrochemical, optical, magnetic, etc.), engineering of different biosensing platforms, operation of biosensors in vitro and in vivo (implantable or wearable devices), self-powered biosensors, etc. The biosensors can be represented with analogue devices measuring concentrations of analytes and binary devices operating in the YES/NO format, possibly with logical processing of input signals. Furthermore, the book is aimed at attracting young scientists and introducing them to the field, while providing newcomers with an enormous collection of literature references.

Technology: general issues --- metabolite sensors --- sensor biocompatibility --- ion selective electrodes --- foreign body reaction --- O2 --- glucose --- lactate --- biosensors --- bioelectrochemistry --- photo-biosensors --- enzyme --- biocatalysis --- electrochemical biosensors --- real-time --- continuous operation --- reagentless --- reusable --- calibration-free --- antibiofouling --- biosensor --- biomimetic membranes --- membrane-bound enzymes --- electrodes --- sulfur-containing nanomaterials --- metallic sulfide nanomaterials --- sulfur-containing quantum dots --- enzyme-based biosensors --- direct electron transfer (DET) --- redox enzymes --- nanostructured electrodes --- protein film voltammetry (PFV) --- glucose biosensors --- nanoporous metals --- nanoporous gold --- graphene --- carbon nanotube --- ordered mesoporous carbon --- additive manufacturing --- heme --- peroxidases --- semiconductors --- peroxidase mimics --- DNA assay --- nucleic acid --- isothermal --- signal amplification --- restriction endonuclease --- wearable biosensors --- metabolism --- remote monitoring --- sweat --- microfluidic --- 3D printing --- nanoparticle --- nanocomposite --- nanozyme --- synthesis --- catalytic properties --- nano-peroxidase --- nanooxidase --- nanolaccase --- electronanocatalyst --- amperometric (bio)sensors --- POC --- microfluidics --- immunosensor --- cancer --- biomarkers --- electrochemical DNA sensor --- nucleic acid sensor --- DNA --- RNA --- pathogen sensing --- 2D-materials --- field-effect transistor --- transition metal dichalcogenides --- black phosphorus --- phosphorene --- hexagonal boron nitride --- transition metal oxides --- current–potential curve --- multi-enzymatic cascades --- multianalyte detection --- mass-transfer-controlled amperometric response --- potentiometric coulometry --- MXenes --- 2D nanomaterials --- wearables --- electrochemistry --- bacteria --- electrochemical ELISA --- electrochemical immunoassays --- electrochemical aptamer-based assays --- chemical sensor --- field effect --- capacitive EIS sensor --- pH sensor --- enzyme biosensor --- label-free detection --- charged molecules --- DNA biosensor --- protein detection --- forensics --- biometrics --- cybersecurity --- fingerprints --- blood --- cipher --- non-invasive biosensors --- human physiological fluids --- tears --- saliva --- urine --- n/a --- current-potential curve

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The present book is devoted to all aspects of biosensing in a very broad definition, including, but not limited to, biomolecular composition used in biosensors (e.g., biocatalytic enzymes, DNAzymes, abiotic nanospecies with biocatalytic features, bioreceptors, DNA/RNA, aptasensors, etc.), physical signal transduction mechanisms (e.g., electrochemical, optical, magnetic, etc.), engineering of different biosensing platforms, operation of biosensors in vitro and in vivo (implantable or wearable devices), self-powered biosensors, etc. The biosensors can be represented with analogue devices measuring concentrations of analytes and binary devices operating in the YES/NO format, possibly with logical processing of input signals. Furthermore, the book is aimed at attracting young scientists and introducing them to the field, while providing newcomers with an enormous collection of literature references.

metabolite sensors --- sensor biocompatibility --- ion selective electrodes --- foreign body reaction --- O2 --- glucose --- lactate --- biosensors --- bioelectrochemistry --- photo-biosensors --- enzyme --- biocatalysis --- electrochemical biosensors --- real-time --- continuous operation --- reagentless --- reusable --- calibration-free --- antibiofouling --- biosensor --- biomimetic membranes --- membrane-bound enzymes --- electrodes --- sulfur-containing nanomaterials --- metallic sulfide nanomaterials --- sulfur-containing quantum dots --- enzyme-based biosensors --- direct electron transfer (DET) --- redox enzymes --- nanostructured electrodes --- protein film voltammetry (PFV) --- glucose biosensors --- nanoporous metals --- nanoporous gold --- graphene --- carbon nanotube --- ordered mesoporous carbon --- additive manufacturing --- heme --- peroxidases --- semiconductors --- peroxidase mimics --- DNA assay --- nucleic acid --- isothermal --- signal amplification --- restriction endonuclease --- wearable biosensors --- metabolism --- remote monitoring --- sweat --- microfluidic --- 3D printing --- nanoparticle --- nanocomposite --- nanozyme --- synthesis --- catalytic properties --- nano-peroxidase --- nanooxidase --- nanolaccase --- electronanocatalyst --- amperometric (bio)sensors --- POC --- microfluidics --- immunosensor --- cancer --- biomarkers --- electrochemical DNA sensor --- nucleic acid sensor --- DNA --- RNA --- pathogen sensing --- 2D-materials --- field-effect transistor --- transition metal dichalcogenides --- black phosphorus --- phosphorene --- hexagonal boron nitride --- transition metal oxides --- current–potential curve --- multi-enzymatic cascades --- multianalyte detection --- mass-transfer-controlled amperometric response --- potentiometric coulometry --- MXenes --- 2D nanomaterials --- wearables --- electrochemistry --- bacteria --- electrochemical ELISA --- electrochemical immunoassays --- electrochemical aptamer-based assays --- chemical sensor --- field effect --- capacitive EIS sensor --- pH sensor --- enzyme biosensor --- label-free detection --- charged molecules --- DNA biosensor --- protein detection --- forensics --- biometrics --- cybersecurity --- fingerprints --- blood --- cipher --- non-invasive biosensors --- human physiological fluids --- tears --- saliva --- urine --- n/a --- current-potential curve

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• Reference Manager
• EndNote
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The present book is devoted to all aspects of biosensing in a very broad definition, including, but not limited to, biomolecular composition used in biosensors (e.g., biocatalytic enzymes, DNAzymes, abiotic nanospecies with biocatalytic features, bioreceptors, DNA/RNA, aptasensors, etc.), physical signal transduction mechanisms (e.g., electrochemical, optical, magnetic, etc.), engineering of different biosensing platforms, operation of biosensors in vitro and in vivo (implantable or wearable devices), self-powered biosensors, etc. The biosensors can be represented with analogue devices measuring concentrations of analytes and binary devices operating in the YES/NO format, possibly with logical processing of input signals. Furthermore, the book is aimed at attracting young scientists and introducing them to the field, while providing newcomers with an enormous collection of literature references.

Technology: general issues --- metabolite sensors --- sensor biocompatibility --- ion selective electrodes --- foreign body reaction --- O2 --- glucose --- lactate --- biosensors --- bioelectrochemistry --- photo-biosensors --- enzyme --- biocatalysis --- electrochemical biosensors --- real-time --- continuous operation --- reagentless --- reusable --- calibration-free --- antibiofouling --- biosensor --- biomimetic membranes --- membrane-bound enzymes --- electrodes --- sulfur-containing nanomaterials --- metallic sulfide nanomaterials --- sulfur-containing quantum dots --- enzyme-based biosensors --- direct electron transfer (DET) --- redox enzymes --- nanostructured electrodes --- protein film voltammetry (PFV) --- glucose biosensors --- nanoporous metals --- nanoporous gold --- graphene --- carbon nanotube --- ordered mesoporous carbon --- additive manufacturing --- heme --- peroxidases --- semiconductors --- peroxidase mimics --- DNA assay --- nucleic acid --- isothermal --- signal amplification --- restriction endonuclease --- wearable biosensors --- metabolism --- remote monitoring --- sweat --- microfluidic --- 3D printing --- nanoparticle --- nanocomposite --- nanozyme --- synthesis --- catalytic properties --- nano-peroxidase --- nanooxidase --- nanolaccase --- electronanocatalyst --- amperometric (bio)sensors --- POC --- microfluidics --- immunosensor --- cancer --- biomarkers --- electrochemical DNA sensor --- nucleic acid sensor --- DNA --- RNA --- pathogen sensing --- 2D-materials --- field-effect transistor --- transition metal dichalcogenides --- black phosphorus --- phosphorene --- hexagonal boron nitride --- transition metal oxides --- current-potential curve --- multi-enzymatic cascades --- multianalyte detection --- mass-transfer-controlled amperometric response --- potentiometric coulometry --- MXenes --- 2D nanomaterials --- wearables --- electrochemistry --- bacteria --- electrochemical ELISA --- electrochemical immunoassays --- electrochemical aptamer-based assays --- chemical sensor --- field effect --- capacitive EIS sensor --- pH sensor --- enzyme biosensor --- label-free detection --- charged molecules --- DNA biosensor --- protein detection --- forensics --- biometrics --- cybersecurity --- fingerprints --- blood --- cipher --- non-invasive biosensors --- human physiological fluids --- tears --- saliva --- urine