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Trois cent cinquante millions de porteurs chroniques dans le monde, environ un million de décès chaque année, un vaccin efficace mais décrié en France, des traitements de plus en plus performants mais inaccessibles dans les régions les plus touchées par l’endémie. Près d’un demi-siècle après la découverte du virus de l'hépatite B, les défis posés par l'infection restent considérables. L'estimation récente de l'Institut de veille sanitaire a montré que la prévalence de l'infection par le virus de l'hépatite B était voisine de celle de l'infection par le virus de l'hépatite C en France. Les populations migrantes et les couches les plus défavorisées de la société sont les plus touchées. Le développement récent de molécules antivirales puissantes possédant une barrière génétique élevée contre la résistance permet en théorie de contrôler la très grande majorité des hépatites chroniques B. Cependant, l'obligation de traiter longtemps, sans doute à vie, une infection a priori incurable pose des problèmes difficiles d'indication thérapeutique, d'observance et de résistance. Aux campagnes de vaccination massive des nouveau-nés, enfants et adolescents dans la plupart des pays d'Asie, d'Europe et d'Afrique, la France oppose un décalage qui devrait être rapidement corrigé. La publication d'un ouvrage de référence sur l'hépatite B, après celui sur l'hépatite C, s'imposait donc. Les meilleurs spécialistes français se sont réunis pour faire le point sur les connaissances les plus récentes, sous l'oeil bienveillant de Harvey Alter, co-découvreur du virus de l'hépatite B avec Baruch Blumberg, prix Nobel de Médecine, alors que l'European Association for the Study of the Liver (EASL) publiait ses première recommandations de pratiques cliniques sur la prise en charge de l'hépatite chronique B et que notre ministre lançait, pour les années 2009-2012, un nouveau plan de lutte contre les hépatites virales. La publication de cet ouvrage arrive, nous semble-t-il, bien à propos.
Hepatitis B. --- Hepatitis, Viral. --- Hepatitis, Viral, Human --- Hepadnaviridae Infections --- Hepatitis --- DNA Virus Infections --- Virus Diseases --- Diseases --- Liver Diseases --- Digestive System Diseases --- Hepatitis B --- Digestive System Disease --- Disease, Digestive System --- Diseases, Digestive System --- System Disease, Digestive --- System Diseases, Digestive --- Liver Dysfunction --- Disease, Liver --- Diseases, Liver --- Dysfunction, Liver --- Dysfunctions, Liver --- Liver Disease --- Liver Dysfunctions --- Viral Diseases --- Viral Infections --- Virus Infections --- Disease, Viral --- Disease, Virus --- Diseases, Viral --- Diseases, Virus --- Infection, Viral --- Infection, Virus --- Infections, Viral --- Infections, Virus --- Viral Disease --- Viral Infection --- Virus Disease --- Virus Infection --- Infections, DNA Virus --- DNA Virus Infection --- Infection, DNA Virus --- Virus Infection, DNA --- Virus Infections, DNA --- Hepatitides --- Infections, Hepadnaviridae --- Hepadnaviridae Infection --- Infection, Hepadnaviridae --- Hepatitis B Virus Infection --- Viral Hepatitis, Human --- Human Viral Hepatitides --- Human Viral Hepatitis --- Viral Hepatitides, Human --- Digestive System Disorders --- Hepatobiliary Diseases --- Hepatobiliary Disorders --- Digestive System Disorder --- Hepatobiliary Disease --- Hepatobiliary Disorder --- System Disorders, Digestive
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Though smallpox was eradicated from the planet two decades ago, recent terrorist acts have raised the horrific possibility that rogue states, laboratories, or terrorist groups are in possession of secret stockpiles of the virus that causes the disease, and may be preparing to unleash it on target populations.
Cultures and culture media. --- Epidemiology. --- Health Policy. --- International cooperation. --- Prevention. --- prevention & control. --- Smallpox. --- Variola virus. --- Smallpox --- Orthopoxvirus --- Public Policy --- North America --- Internationality --- Europe, Eastern --- Poxviridae Infections --- Social Sciences --- DNA Virus Infections --- Social Control Policies --- Americas --- Chordopoxvirinae --- Europe --- Social Control, Formal --- Policy --- Poxviridae --- Virus Diseases --- Geographic Locations --- Anthropology, Education, Sociology and Social Phenomena --- Sociology --- DNA Viruses --- Health Care Economics and Organizations --- Diseases --- Geographicals --- Health Care --- Viruses --- Vertebrate Viruses --- Organisms --- International Cooperation --- Health Policy --- Variola virus --- Russia --- United States --- Public Health --- Health & Biological Sciences --- Communicable Diseases --- Healthcare Policy --- National Health Policy --- Health Policies --- Health Policy, National --- Healthcare Policies --- National Health Policies --- Policy, Health --- Policy, Healthcare --- Policy, National Health --- Policy Making --- Alastrim --- Variola --- Variola Minor --- Minor, Variola --- Minors, Variola --- Variola Minors --- Variolas --- Poxvirus variolae --- Smallpox Virus --- Smallpox Viruses --- Variola viruses --- Treaties --- Foreign Aid --- Aid, Foreign --- Cooperation, International --- Treaty --- Animal Viruses --- Zoophaginae --- Animal Virus --- Virus --- Virus, Animal --- Viruses, Animal --- Genetic Vectors --- Microbiology --- Community-Based Distribution --- Contraceptive Distribution --- Delivery of Healthcare --- Dental Care Delivery --- Distribution, Non-Clinical --- Distribution, Nonclinical --- Distributional Activities --- Healthcare --- Healthcare Delivery --- Healthcare Systems --- Non-Clinical Distribution --- Nonclinical Distribution --- Delivery of Dental Care --- Health Care Delivery --- Health Care Systems --- Activities, Distributional --- Activity, Distributional --- Care, Health --- Community Based Distribution --- Community-Based Distributions --- Contraceptive Distributions --- Deliveries, Healthcare --- Delivery, Dental Care --- Delivery, Health Care --- Delivery, Healthcare --- Distribution, Community-Based --- Distribution, Contraceptive --- Distribution, Non Clinical --- Distributional Activity --- Distributions, Community-Based --- Distributions, Contraceptive --- Distributions, Non-Clinical --- Distributions, Nonclinical --- Health Care System --- Healthcare Deliveries --- Healthcare System --- Non Clinical Distribution --- Non-Clinical Distributions --- Nonclinical Distributions --- System, Health Care --- System, Healthcare --- Systems, Health Care --- Systems, Healthcare --- Healthcare Economics and Organizations --- Health Care Economics --- Health Economics --- Healthcare Economics --- Care Economic, Health --- Economic, Health --- Economic, Health Care --- Economic, Healthcare --- Economics, Health Care --- Health Care Economic --- Health Economic --- Healthcare Economic --- DNA Virus --- Virus, DNA --- Viruses, DNA --- General Social Development and Population --- Viral Diseases --- Viral Infections --- Virus Infections --- Disease, Viral --- Disease, Virus --- Diseases, Viral --- Diseases, Virus --- Infection, Viral --- Infection, Virus --- Infections, Viral --- Infections, Virus --- Viral Disease --- Viral Infection --- Virus Disease --- Virus Infection --- Poxviruses --- Policies --- Regulation --- Social Control --- Control, Social --- Controls, Social --- Formal Social Control --- Formal Social Controls --- Regulations --- Social Controls --- Control Policies, Social --- Control Policy, Social --- Policies, Social Control --- Policy, Social Control --- Social Control Policy --- Infections, DNA Virus --- DNA Virus Infection --- Infection, DNA Virus --- Virus Infection, DNA --- Virus Infections, DNA --- Science, Social --- Sciences, Social --- Social Science --- Globalization --- International Aspects --- International Perspectives --- International Relations --- Multinational Aspects --- Multinational Perspectives --- Aspect, International --- Aspect, Multinational --- Aspects, International --- Aspects, Multinational --- International Aspect --- International Perspective --- Multinational Aspect --- Multinational Perspective --- Perspective, International --- Perspective, Multinational --- Perspectives, International --- Perspectives, Multinational --- Relations, International --- International Law --- Infections, Poxviridae --- Infections, Poxvirus --- Milker's Nodes --- Poxvirus Infections --- Infection, Poxviridae --- Infection, Poxvirus --- Milker Nodes --- Milker's Node --- Milkers Nodes --- Node, Milker's --- Nodes, Milker's --- Poxviridae Infection --- Poxvirus Infection --- Affirmative Action --- Migration Policy --- Population Policy --- Social Protection --- Social Policy --- Action, Affirmative --- Migration Policies --- Policies, Migration --- Policies, Population --- Policies, Public --- Policies, Social --- Policy, Migration --- Policy, Population --- Policy, Public --- Policy, Social --- Population Policies --- Protection, Social --- Public Policies --- Social Policies --- Camelpox virus --- Horsepox virus --- Raccoonpox virus --- Skunkpox virus --- Taterapox virus --- Volepox virus --- Camelpox viruses --- Horsepox viruses --- Orthopoxviruses --- Raccoonpox viruses --- Skunkpox viruses --- Taterapox viruses --- Volepox viruses --- virus, Camelpox --- virus, Horsepox --- virus, Raccoonpox --- virus, Skunkpox --- virus, Taterapox --- virus, Volepox --- Small pox --- Varioloid --- Poxvirus diseases --- Prevention --- Epidemiology --- Cultures and culture media --- Vertebrates --- virology --- Russian Federation (Europe) --- Russian SFSR --- Russian S.F.S.R. --- Geographic Location --- Northern Europe --- Southern Europe --- Western Europe --- America --- Eastern Europe --- Northern America --- Health Care Policies --- Care Policies, Health --- Health Care Policy --- Policies, Health --- Policies, Health Care --- Policies, Healthcare --- Policy, Health Care
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Human medicine --- Hepatitis, Viral, Human --- Liver Neoplasms --- Flaviviridae Infections --- Drug Resistance, Microbial --- Virus Physiological Phenomena --- Hepadnaviridae Infections --- Adenocarcinoma --- Carcinoma, Hepatocellular --- Hepatitis C --- Drug Resistance, Viral --- Hepatitis B --- Hepatitis --- Microbiological Phenomena --- Digestive System Neoplasms --- Drug Resistance --- Virus Diseases --- Carcinoma --- DNA Virus Infections --- RNA Virus Infections --- Liver Diseases --- Digestive System Diseases --- Neoplasms by Site --- Diseases --- Phenomena and Processes --- Neoplasms, Glandular and Epithelial --- Pharmacological Phenomena --- Neoplasms --- Neoplasms by Histologic Type --- Physiological Phenomena --- Medicine --- Gastroenterology --- Health & Biological Sciences --- Physiological Concepts --- Physiological Phenomenon --- Physiological Process --- Physiological Processes --- Concept, Physiological --- Concepts, Physiological --- Phenomena, Physiological --- Phenomenas, Physiological --- Phenomenon, Physiological --- Physiological Concept --- Process, Physiological --- Processes, Physiological --- Histological Type of Neoplasm --- Histological Types of Neoplasms --- Neoplasms by Histological Type --- Neoplasm Histological Type --- Neoplasm Histological Types --- Neoplasms Histological Type --- Neoplasms Histological Types --- Benign Neoplasms --- Malignancy --- Malignant Neoplasms --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Malignant Neoplasm --- Neoplasias --- Neoplasm, Benign --- Neoplasm, Malignant --- Neoplasms, Malignant --- Tumor --- Medical Oncology --- Pharmacologic Phenomena --- Pharmacologic Phenomenon --- Pharmacologic Process --- Pharmacological Concepts --- Pharmacological Phenomenon --- Pharmacologic Processes --- Pharmacological Processes --- Concept, Pharmacological --- Concepts, Pharmacological --- Pharmacological Concept --- Phenomena, Pharmacologic --- Phenomena, Pharmacological --- Phenomenon, Pharmacologic --- Phenomenon, Pharmacological --- Process, Pharmacologic --- Processes, Pharmacologic --- Processes, Pharmacological --- Epithelial Neoplasms --- Glandular Neoplasms --- Glandular and Epithelial Neoplasms --- Neoplasms, Epithelial --- Neoplasms, Glandular --- Neoplasms, Glandular Epithelial --- Epithelial Neoplasm --- Epithelial Neoplasm, Glandular --- Epithelial Neoplasms, Glandular --- Glandular Epithelial Neoplasm --- Glandular Epithelial Neoplasms --- Glandular Neoplasm --- Neoplasm, Epithelial --- Neoplasm, Glandular --- Neoplasm, Glandular Epithelial --- Neoplasms by Sites --- Site, Neoplasm --- Sites, Neoplasm --- Neoplasm Site --- Neoplasm Sites --- Digestive System Disorders --- Hepatobiliary Diseases --- Hepatobiliary Disorders --- Digestive System Disease --- Digestive System Disorder --- Hepatobiliary Disease --- Hepatobiliary Disorder --- System Disorders, Digestive --- Liver Dysfunction --- Disease, Liver --- Diseases, Liver --- Dysfunction, Liver --- Dysfunctions, Liver --- Liver Disease --- Liver Dysfunctions --- Infections, RNA Virus --- Infection, RNA Virus --- RNA Virus Infection --- Virus Infection, RNA --- Virus Infections, RNA --- Infections, DNA Virus --- DNA Virus Infection --- Infection, DNA Virus --- Virus Infection, DNA --- Virus Infections, DNA --- Epithelial Tumors, Malignant --- Malignant Epithelial Neoplasms --- Neoplasms, Malignant Epithelial --- Carcinoma, Anaplastic --- Carcinoma, Spindle-Cell --- Carcinoma, Undifferentiated --- Carcinomatosis --- Epithelial Neoplasms, Malignant --- Epithelioma --- Anaplastic Carcinoma --- Anaplastic Carcinomas --- Carcinoma, Spindle Cell --- Carcinomas --- Carcinomatoses --- Epithelial Neoplasm, Malignant --- Epithelial Tumor, Malignant --- Epitheliomas --- Malignant Epithelial Neoplasm --- Malignant Epithelial Tumor --- Malignant Epithelial Tumors --- Neoplasm, Malignant Epithelial --- Spindle-Cell Carcinoma --- Spindle-Cell Carcinomas --- Tumor, Malignant Epithelial --- Undifferentiated Carcinoma --- Undifferentiated Carcinomas --- Viral Diseases --- Viral Infections --- Virus Infections --- Disease, Viral --- Disease, Virus --- Diseases, Viral --- Diseases, Virus --- Infection, Viral --- Infection, Virus --- Infections, Viral --- Infections, Virus --- Viral Disease --- Viral Infection --- Virus Disease --- Virus Infection --- Resistance, Drug --- Pharmacogenetics --- Cancer of the Digestive System --- Neoplasms, Digestive System --- Cancer of Digestive System --- Digestive System Cancer --- Cancer, Digestive System --- Cancers, Digestive System --- Digestive System Cancers --- Digestive System Neoplasm --- Neoplasm, Digestive System --- Microbial Concepts --- Microbial Phenomena --- Microbiologic Concepts --- Microbiological Phenomenon --- Microbiological Process --- Phenomena, Microbiologic --- Microbiologic Phenomena --- Microbiological Processes --- Concept, Microbial --- Concept, Microbiologic --- Concepts, Microbial --- Concepts, Microbiologic --- Microbial Concept --- Microbiologic Concept --- Phenomena, Microbial --- Phenomena, Microbiological --- Phenomenon, Microbiological --- Process, Microbiological --- Processes, Microbiological --- Dysbiosis --- Hepatitides --- Hepatitis B Virus Infection --- Antiviral Drug Resistance --- Antiviral Drug Resistances --- Drug Resistances, Viral --- PT-NANBH --- Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted --- Parenterally-Transmitted Non-A, Non-B Hepatitis --- Parenterally Transmitted Non A, Non B Hepatitis --- Liver Cancer, Adult --- Liver Cell Carcinoma --- Liver Cell Carcinoma, Adult --- Hepatocellular Carcinoma --- Hepatoma --- Adult Liver Cancer --- Adult Liver Cancers --- Cancer, Adult Liver --- Cancers, Adult Liver --- Carcinoma, Liver Cell --- Carcinomas, Hepatocellular --- Carcinomas, Liver Cell --- Cell Carcinoma, Liver --- Cell Carcinomas, Liver --- Hepatocellular Carcinomas --- Hepatomas --- Liver Cancers, Adult --- Liver Cell Carcinomas --- Adenocarcinoma, Basal Cell --- Adenocarcinoma, Granular Cell --- Adenocarcinoma, Oxyphilic --- Adenocarcinoma, Tubular --- Adenoma, Malignant --- Carcinoma, Cribriform --- Carcinoma, Granular Cell --- Carcinoma, Tubular --- Adenocarcinomas --- Adenocarcinomas, Basal Cell --- Adenocarcinomas, Granular Cell --- Adenocarcinomas, Oxyphilic --- Adenocarcinomas, Tubular --- Adenomas, Malignant --- Basal Cell Adenocarcinoma --- Basal Cell Adenocarcinomas --- Carcinomas, Cribriform --- Carcinomas, Granular Cell --- Carcinomas, Tubular --- Cribriform Carcinoma --- Cribriform Carcinomas --- Granular Cell Adenocarcinoma --- Granular Cell Adenocarcinomas --- Granular Cell Carcinoma --- Granular Cell Carcinomas --- Malignant Adenoma --- Malignant Adenomas --- Oxyphilic Adenocarcinoma --- Oxyphilic Adenocarcinomas --- Tubular Adenocarcinoma --- Tubular Adenocarcinomas --- Tubular Carcinoma --- Tubular Carcinomas --- Carcinoma, Non-Small-Cell Lung --- Infections, Hepadnaviridae --- Hepadnaviridae Infection --- Infection, Hepadnaviridae --- Physiology, Viral --- Viral Physiological Concepts --- Viral Physiological Phenomena --- Viral Physiological Process --- Virus Physiological Concepts --- Virus Physiological Phenomenon --- Virus Physiological Process --- Virus Physiology --- Viral Physiological Processes --- Viral Physiology --- Virus Physiological Processes --- Concept, Viral Physiological --- Concept, Virus Physiological --- Concepts, Viral Physiological --- Concepts, Virus Physiological --- Phenomena, Viral Physiological --- Phenomena, Virus Physiological --- Phenomenon, Virus Physiological --- Phenomenons, Virus Physiological --- Physiological Process, Viral --- Physiological Process, Virus --- Physiological Processes, Viral --- Physiological Processes, Virus --- Physiology, Virus --- Process, Viral Physiological --- Process, Virus Physiological --- Processes, Viral Physiological --- Processes, Virus Physiological --- Viral Physiological Concept --- Virus Physiological Concept --- Viruses --- Antimicrobial Drug Resistance --- Antibiotic Resistance --- Antibiotic Resistance, Microbial --- Antimicrobial Drug Resistances --- Drug Resistances, Microbial --- Resistance, Antibiotic --- Microbial Sensitivity Tests --- Infections, Flaviviridae --- Flaviviridae Infection --- Infection, Flaviviridae --- Cancer of the Liver --- Cancer, Hepatocellular --- Hepatic Neoplasms --- Hepatocellular Cancer --- Neoplasms, Hepatic --- Neoplasms, Liver --- Cancer of Liver --- Hepatic Cancer --- Liver Cancer --- Cancer, Hepatic --- Cancer, Liver --- Cancers, Hepatic --- Cancers, Hepatocellular --- Cancers, Liver --- Hepatic Cancers --- Hepatic Neoplasm --- Hepatocellular Cancers --- Liver Cancers --- Liver Neoplasm --- Neoplasm, Hepatic --- Neoplasm, Liver --- Viral Hepatitis, Human --- Human Viral Hepatitides --- Human Viral Hepatitis --- Viral Hepatitides, Human --- physiology --- Epithelial Cell Neoplasms --- Glandular Cell Neoplasms --- Cell Neoplasm, Epithelial --- Cell Neoplasm, Glandular --- Cell Neoplasms, Epithelial --- Epithelial Cell Neoplasm --- Glandular Cell Neoplasm --- Neoplasm, Epithelial Cell --- Neoplasm, Glandular Cell
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