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This book is a comprehensive review of the detailed molecular mechanisms of and functional crosstalk among the replication, recombination, and repair of DNA (collectively called the "3Rs") and the related processes, with special consciousness of their biological and clinical consequences. The 3Rs are fundamental molecular mechanisms for organisms to maintain and sometimes intentionally alter genetic information. DNA replication, recombination, and repair, individually, have been important subjects of molecular biology since its emergence, but we have recently become aware that the 3Rs are actually much more intimately related to one another than we used to realize. Furthermore, the 3R research fields have been growing even more interdisciplinary, with better understanding of molecular mechanisms underlying other important processes, such as chromosome structures and functions, cell cycle and checkpoints, transcriptional and epigenetic regulation, and so on. This book comprises 7 parts and 21 chapters: Part 1 (Chapters 1–3), DNA Replication; Part 2 (Chapters 4–6), DNA Recombination; Part 3 (Chapters 7–9), DNA Repair; Part 4 (Chapters 10–13), Genome Instability and Mutagenesis; Part 5 (Chapters 14–15), Chromosome Dynamics and Functions; Part 6 (Chapters 16–18), Cell Cycle and Checkpoints; Part 7 (Chapters 19–21), Interplay with Transcription and Epigenetic Regulation. This volume should attract the great interest of graduate students, postdoctoral fellows, and senior scientists in broad research fields of basic molecular biology, not only the core 3Rs, but also the various related fields (chromosome, cell cycle, transcription, epigenetics, and similar areas). Additionally, researchers in neurological sciences, developmental biology, immunology, evolutionary biology, and many other fields will find this book valuable.
DNA replication --- DNA repair --- Gene rearrangement --- Recombination, Genetic --- Genetics --- DNA Replication --- DNA Repair --- Pathologic Processes --- Biochemical Processes --- Pathological Conditions, Signs and Symptoms --- Genetic Processes --- Biology --- Diseases --- Biochemical Phenomena --- Biological Science Disciplines --- Genetic Phenomena --- Chemical Phenomena --- Phenomena and Processes --- Natural Science Disciplines --- Disciplines and Occupations --- Cytology --- Health & Biological Sciences --- DNA replication. --- DNA repair. --- Gene rearrangement. --- DNA rearrangement --- Deoxyribonucleic acid repair --- Repair, DNA --- Repair mechanisms in DNA --- Chromosomal DNA replication --- DNA --- Replication of DNA --- Replication --- Molecular genetics --- Antibody diversity --- Biochemical genetics --- Antimutagens --- Synthesis --- Cytology. --- Biochemistry. --- Pathology. --- Human genetics. --- Cell Biology. --- Biochemistry, general. --- Cytogenetics. --- Heredity, Human --- Human biology --- Physical anthropology --- Disease (Pathology) --- Medical sciences --- Medicine --- Medicine, Preventive --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Composition --- Cell biology.
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Cytogenetics --- Cells --- Molecular genetics --- Genes --- Molecular biology --- Cytology --- Biomechanics --- Cell Division --- Gene Expression --- Gene Rearrangement --- Molecular Biology --- Signal Transduction --- Mechanical properties --- Biomechanics. --- Cytogenetics. --- Cytology. --- Genes. --- Molecular biology. --- Molecular genetics. --- Biologie moléculaire. --- Cytologie. --- Signal Transduction. --- Mechanical properties. --- Cell Division. --- Cells. --- Gene Expression. --- Gene Rearrangement. --- Molecular Biology. --- Histology. --- Receptor Mediated Signal Transduction --- Signal Transduction Pathways --- Signal Transduction Systems --- Receptor-Mediated Signal Transduction --- Signal Pathways --- Pathway, Signal --- Pathway, Signal Transduction --- Pathways, Signal --- Pathways, Signal Transduction --- Receptor-Mediated Signal Transductions --- Signal Pathway --- Signal Transduction Pathway --- Signal Transduction System --- Signal Transduction, Receptor-Mediated --- Signal Transductions --- Signal Transductions, Receptor-Mediated --- System, Signal Transduction --- Systems, Signal Transduction --- Transduction, Signal --- Transductions, Signal --- Biochemical Genetics --- Biology, Molecular --- Genetics, Biochemical --- Genetics, Molecular --- Molecular Genetics --- Biochemical Genetic --- Genetic, Biochemical --- Genetic, Molecular --- Molecular Genetic --- Cistron --- Gene --- Genetic Materials --- Cistrons --- Genetic Material --- Material, Genetic --- Materials, Genetic --- Biological mechanics --- Mechanical properties of biological structures --- DNA Rearrangement --- DNA Rearrangements --- Gene Rearrangements --- Rearrangement, DNA --- Rearrangement, Gene --- Rearrangements, DNA --- Rearrangements, Gene --- Molecular biochemistry --- Molecular biophysics --- Units of heredity --- Units of inheritance --- Cell biology --- Cellular biology --- Cell mechanics --- Cellular mechanics --- Expression, Gene --- Expressions, Gene --- Gene Expressions --- Cell --- Cell Division Phase --- Cell Divisions --- M Phase --- Division Phase, Cell --- Division, Cell --- Divisions, Cell --- M Phases --- Phase, Cell Division --- Phase, M --- Phases, M --- Cell Communication --- Receptor-CD3 Complex, Antigen, T-Cell --- Receptor Cross-Talk --- Feedback, Physiological --- Gasotransmitters --- Genetic Phenomena --- Genome --- VDJ Recombinases --- Gene Expression Profiling --- Cell Biology --- Cleavage Stage, Ovum --- Biophysics --- Mechanics --- Contractility (Biology) --- Genetics --- Biochemistry --- Biomolecules --- Systems biology --- Heredity --- DNA --- Biology --- Cytologists --- Organisms --- Biologie moléculaire. --- Cell Signaling --- Gene expression. --- Gene rearrangement. --- Cellular signal transduction. --- Cytogénétique --- Cellules --- Génétique moléculaire --- Gènes --- Biologie moléculaire --- Cytologie --- Biomécanique --- Cellules. --- Expression génique. --- Réarrangement des gènes. --- Gènes. --- Transduction du signal cellulaire. --- Propriétés mécaniques --- Genetic regulation --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- DNA rearrangement --- Antibody diversity --- Expression
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