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BACTERIOPHAGES --- DNA-DIRECTED DNA POLYMERASE --- BACTERIOPHAGES --- DNA-DIRECTED DNA POLYMERASE
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NUCLEOSIDES --- NUCLEOTIDES --- DNA-DIRECTED DNA POLYMERASE --- NUCLEOSIDES --- NUCLEOTIDES --- DNA-DIRECTED DNA POLYMERASE
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DNA-DIRECTED DNA POLYMERASE --- DNA REPLICATION --- DNA-DIRECTED DNA POLYMERASE --- DNA REPLICATION
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DNA-Directed DNA Polymerase --- physiology --- therapeutic use --- DNA polymerases. --- Biotechnology. --- ADN polymérases. --- Biotechnologie --- Physiologie --- Emploi en thérapeutique --- DNA-Directed DNA Polymerase - physiology --- DNA-Directed DNA Polymerase - therapeutic use --- ADN polymérases. --- Emploi en thérapeutique
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Molecular biology --- DNA replication --- DNA-replicatie --- Réplication de l'ADN --- DNA Replication. --- DNA Replication --- ADN polymérases --- ADN --- Dna formation --- Dna-directed dna polymerase
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Biological techniques --- Enzymology --- Molecular biology --- Gene amplification --- Polymerase chain reaction --- DNA-Directed DNA Polymerase --- Gene Amplification --- Molecular Biology --- DNA-Directed RNA Polymerases --- DNA-Directed DNA Polymerase. --- Gene Amplification. --- Molecular Biology. --- DNA-Directed RNA Polymerases. --- Chain reaction, Polymerase --- PCR (Biochemistry) --- Polymerization --- DNA polymerases --- Amplification, Gene --- Gene expression --- Biochemical Genetics --- Biology, Molecular --- Genetics, Biochemical --- Genetics, Molecular --- Molecular Genetics --- Biochemical Genetic --- Genetic, Biochemical --- Genetic, Molecular --- Molecular Genetic --- Gene amplification. --- Polymerase chain reaction. --- DNA Polymerases. --- Genetic Engineering. --- Molecular biology. --- RNA Polymerases. --- Genetic Phenomena --- Dna polymerases. --- Genetic engineering. --- Rna polymerases. --- Genetic Engineering --- DNA --- ADN polymérases --- ADN --- Synthesis --- Biotechnology --- Synthèse --- Biotechnologie --- DNA-Directed RNA Polymerase --- RNA Polymerase --- Transcriptase --- DNA-Dependent RNA Polymerases --- RNA Polymerases --- Transcriptases --- DNA Dependent RNA Polymerases --- DNA Directed RNA Polymerase --- DNA Directed RNA Polymerases --- Polymerase, DNA-Directed RNA --- Polymerase, RNA --- Polymerases, DNA-Dependent RNA --- Polymerases, DNA-Directed RNA --- Polymerases, RNA --- RNA Polymerase, DNA-Directed --- RNA Polymerases, DNA-Dependent --- RNA Polymerases, DNA-Directed --- DNA Polymerase N3 --- DNA Polymerases --- DNA-Dependent DNA Polymerases --- DNA Dependent DNA Polymerases --- DNA Directed DNA Polymerase --- DNA Polymerase, DNA-Directed --- DNA Polymerases, DNA-Dependent --- Polymerase N3, DNA --- Polymerase, DNA-Directed DNA --- Polymerases, DNA --- Polymerases, DNA-Dependent DNA --- DNA Polymerase --- Polymerase, DNA --- Dna polymerases --- Rna polymerases
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The Reverse Transcriptase (RT) of Human Immunodeficiency Virus Type 1 (HIV-1) arguably ranks amongst one of the most extensively studied retroviral enzymes. Heterologous expression and purification of HIV-1 RT in the early eighties, approval of the first nucleoside analogue RT inhibitor (NRTI) in 1987, discovery of resistance to RT inhibitors, approval of the first non-nucleoside analogue RT inhibitor (NNRTI) in 1996 and the various crystal structures of RT with and without bound substrate(s) and/or inhibitors represent only a few of the important milestones that describe the a bench-to-bedside success in the continuing effort to combat HIV-1 infection and its consequences. Nucleoside and nonnucleoside RT inhibitors remain important components in frequently used drug regimens to treat the infection. RT inhibitors also play important roles in recently validated strategies to prevent transmission of the virus. The relevance of HIV-1 RT as a drug target has simultaneously triggered interest in basic research studies aimed at providing a more detailed understanding of interactions between proteins, nucleic acids, and small molecule ligands in general terms. In light of the ever-growing knowledge on structure and function of HIV-1 RT, this enzyme serves as a valuable “model system” in efforts to develop novel experimental tools and to explain biochemical processes. This monograph is designed to provide an overview of important aspects in past and current HIV-1 RT research, with focus on mechanistic aspects and translation of knowledge into drug discovery and development. The first section includes chapters with emphasis placed on the coordination of the RT-associated DNA polymerase and ribonuclease H (RNase H) activities. The second covers mechanisms of action and future perspectives associated with NRTIs and NNRTIs, while the third section includes chapters focusing on novel strategies to target the RT enzyme. Chapters of the final part are intended to discuss mechanisms involved in HIV variability and the development of drug resistance. We hope that these contributions will stimulate interest, and encourage research aimed at the development of novel RT inhibitors. The lack of bona fide RNase H inhibitors with potent antiviral activity provides an example for challenges and opportunities in the field.
HIV (Viruses) --- Reverse transcriptase --- RNA-Directed DNA Polymerase --- DNA-Directed DNA Polymerase --- DNA Nucleotidyltransferases --- Nucleotidyltransferases --- Phosphotransferases --- Transferases --- Enzymes --- Enzymes and Coenzymes --- Chemicals and Drugs --- HIV Reverse Transcriptase --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Immunology. --- HIV infections --- Research --- Methodology. --- HIV (Viruses) infections --- HTLV-III infections --- HTLV-III-LAV infections --- Human T-lymphotropic virus III infections --- Immunobiology --- Medicine. --- Virology. --- Infectious diseases. --- Biomedicine. --- Infectious Diseases. --- Life sciences --- Serology --- Lentivirus infections --- Sexually transmitted diseases --- Medical virology. --- Emerging infectious diseases. --- Medical microbiology --- Virology --- Virus diseases --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Microbiology
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Molecular biology --- Analytical biochemistry --- DNA Polymerases --- Gene Amplification --- Genetic Engineering --- RNA Polymerases --- Polymerase chain reaction --- Gene amplification --- Réaction en chaîne de la polymérase --- Redondance génétique --- methods --- DNA-Directed RNA Polymerases --- Biologie moléculaire --- Enzymes --- Clonage moléculaire --- molecular cloning --- Virologie --- Virology --- Virus --- viruses --- Identification --- identification --- ADN --- DNA --- ARN --- RNA --- Génétique --- genetics --- Évolution --- evolution --- Expérimentation en laboratoire --- Laboratory experimentation --- Méthodologie --- methodology --- DNA-Directed DNA Polymerase. --- Nucleic Acid Amplification Techniques. --- DNA-Directed RNA Polymerases. --- 577.212.3 --- 57.088.1 --- Chain reaction, Polymerase --- PCR (Biochemistry) --- Polymerization --- DNA polymerases --- Amplification, Gene --- Gene expression --- Amplification Technics, Nucleic Acid --- Amplification Techniques, Nucleic Acid --- DNA Amplification Technics --- Nucleic Acid Amplification Technics --- Nucleic Acid Amplification Test --- Nucleic Acid Amplification Tests --- RNA Amplification Technics --- Technics, Nucleic Acid Amplification --- Techniques, Nucleic Acid Amplification --- DNA Amplification Techniques --- RNA Amplification Techniques --- Amplification Technic, DNA --- Amplification Technic, RNA --- Amplification Technics, DNA --- Amplification Technics, RNA --- Amplification Technique, DNA --- Amplification Technique, RNA --- Amplification Techniques, DNA --- Amplification Techniques, RNA --- DNA Amplification Technic --- DNA Amplification Technique --- RNA Amplification Technic --- RNA Amplification Technique --- Technic, DNA Amplification --- Technic, RNA Amplification --- Technics, DNA Amplification --- Technics, RNA Amplification --- Technique, DNA Amplification --- Technique, RNA Amplification --- Techniques, DNA Amplification --- Techniques, RNA Amplification --- methods. --- Nucleic acid base and sequence compositon. Experimental deciphering of genetic code. --- Methods for analysis and estimation --- Polymerase chain reaction. --- Gene amplification. --- DNA Polymerases. --- RNA Polymerases. --- 57.088.1 Methods for analysis and estimation --- 577.212.3 Nucleic acid base and sequence compositon. Experimental deciphering of genetic code. --- Dna polymerases. --- Genetic engineering --- Rna polymerases. --- Methods. --- Réaction en chaîne de la polymérase --- Redondance génétique --- DNA-Directed DNA Polymerase --- Nucleic Acid Amplification Techniques --- DNA-Directed RNA Polymerase --- RNA Polymerase --- Transcriptase --- DNA-Dependent RNA Polymerases --- Transcriptases --- DNA Dependent RNA Polymerases --- DNA Directed RNA Polymerase --- DNA Directed RNA Polymerases --- Polymerase, DNA-Directed RNA --- Polymerase, RNA --- Polymerases, DNA-Dependent RNA --- Polymerases, DNA-Directed RNA --- Polymerases, RNA --- RNA Polymerase, DNA-Directed --- RNA Polymerases, DNA-Dependent --- RNA Polymerases, DNA-Directed --- DNA Polymerase N3 --- DNA-Dependent DNA Polymerases --- DNA Dependent DNA Polymerases --- DNA Directed DNA Polymerase --- DNA Polymerase, DNA-Directed --- DNA Polymerases, DNA-Dependent --- Polymerase N3, DNA --- Polymerase, DNA-Directed DNA --- Polymerases, DNA --- Polymerases, DNA-Dependent DNA --- Nucleic acid base and sequence compositon. Experimental deciphering of genetic code --- viruses. --- identification. --- DNA. --- RNA. --- evolution. --- Nucleic Acid Amplification Technic --- Nucleic Acid Amplification Technique --- DNA Polymerase --- Polymerase, DNA --- Gene Amplification - methods --- Genetic Engineering - methods --- Polymerases --- Rna --- DNA POLYMERASES --- GENE AMPLIFICATION --- GENETIC ENGINEERING --- RNA POLYMERASES --- METHODS
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Timing, racing, combating, struggling and targeting is some actions through which cellular fate could be reflected and evaluated. Interaction between cell territory and environment occur during pre-embryonic, fetal development, and post-natal periods. What the researchers observe as the outcome of telomeres behavior is only the peak of an ice mountain within a stormy ocean. Cellular life depends on programmed behavior of telomeres, capable to surprise the cells. Telomeres provide an introduction to the history of our cells which govern the quality of life and status of health. Telomeres as the cooperative territory are capable of stabilizing the chromosomal territory. The status of telomeres reflects the key information, announcing the real age of individuals, and may be a valuable marker for prognosis and predicting cancer. Telomere territory is characterized with a multi-disciplinary manner. Therefore, this book is aimed to offer a wide range of chapters, hoping to be useful for diverse audiences, including hematologists-oncologists, radiotherapists, surgeons, cancer researchers, and all the sectors who affect the macro- and micro- environmental domains. Finally, telomeres are sensitive, cooperative, and trustable targets. It is worth to state that ‘telomeres are messengers of NATURE’, let’s to know them as they are.
Aging Longevity. --- Telomere --- Telomerase --- Cancer cells --- Chromosome Structures --- Ribonucleoproteins --- RNA-Directed DNA Polymerase --- Diseases --- RNA-Binding Proteins --- DNA-Directed DNA Polymerase --- Genetic Structures --- Chromosomes --- Intranuclear Space --- DNA Nucleotidyltransferases --- Nucleoproteins --- Genetic Phenomena --- Carrier Proteins --- Phenomena and Processes --- Nucleotidyltransferases --- Cell Nucleus Structures --- Proteins --- Amino Acids, Peptides, and Proteins --- Cell Nucleus --- Phosphotransferases --- Transferases --- Chemicals and Drugs --- Intracellular Space --- Enzymes --- Cellular Structures --- Enzymes and Coenzymes --- Cells --- Anatomy --- Neoplasms --- Biology --- Health & Biological Sciences --- Cytology --- Telomere. --- Telomerase. --- Cancer cells. --- Medicine. --- Cancer research. --- Human genetics. --- Gene expression. --- Stem cells. --- Evolutionary biology. --- Biomedicine. --- Biomedicine general. --- Cancer Research. --- Human Genetics. --- Gene Expression. --- Stem Cells. --- Evolutionary Biology. --- Pathology, Cellular --- DNA polymerases --- Oncology. --- Evolution (Biology). --- Animal evolution --- Animals --- Biological evolution --- Darwinism --- Evolutionary biology --- Evolutionary science --- Origin of species --- Evolution --- Biological fitness --- Homoplasy --- Natural selection --- Phylogeny --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Genes --- Genetic regulation --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Tumors --- Clinical sciences --- Medical profession --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Expression --- Health Workforce --- Biomedicine, general. --- Cancer research
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