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The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1), which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities, which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of the central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.

Cytochrome P-450 -- Metabolism. --- Cytochrome P-450 -- Toxicology. --- Xenobiotics -- Metabolism. --- Cytochrome P-450 CYP2E1 --- Fatty liver --- Metabolic Phenomena --- Stress, Physiological --- Aryl Hydrocarbon Hydroxylases --- Oxidoreductases, N-Demethylating --- Liver Diseases --- Cytochrome P-450 Enzyme System --- Phenomena and Processes --- Oxidoreductases Acting on CH-NH Group Donors --- Digestive System Diseases --- Physiological Processes --- Mixed Function Oxygenases --- Cytochromes --- Physiological Phenomena --- Diseases --- Oxidoreductases --- Oxygenases --- Enzymes --- Hemeproteins --- Enzymes and Coenzymes --- Proteins --- Chemicals and Drugs --- Amino Acids, Peptides, and Proteins --- Metabolism --- Oxidative Stress --- Fatty Liver --- Human Anatomy & Physiology --- Biology --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Animal Biochemistry --- Cytology --- Toxicology --- Pathophysiology --- Cytochrome P-450. --- Medicine. --- Pharmacology. --- Life sciences. --- Biochemistry. --- Biomedicine. --- Pharmacology/Toxicology. --- Life Sciences, general. --- Biochemistry, general. --- Metalloenzymes --- Monooxygenases --- Toxicology. --- Biosciences --- Sciences, Life --- Science --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Composition --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect