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Cancer --- Enzyme inhibitors. --- Cyclin-dependent kinases --- Neoplasms --- Cyclin-Dependent Kinases --- Chemotherapy. --- Inhibitors. --- antagonists & inhibitors --- Benign Neoplasms --- Malignancy --- Malignant Neoplasms --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Malignant Neoplasm --- Neoplasias --- Neoplasm, Benign --- Neoplasm, Malignant --- Neoplasms, Malignant --- Tumor --- Medical Oncology --- CDK proteins --- Cyclin-dependent protein kinases --- Protein kinases --- Antagonists, Enzyme --- Enzyme antagonists --- Enzymes --- Inhibitors, Enzyme --- Metabolic inhibitors --- Chemical inhibitors --- Antineoplastic agents --- Antagonists --- Inhibitors --- Treatment --- Neoplasms. --- antagonists & inhibitors.
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Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during development as well as in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role that Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may have therapeutic potential for the treatment of a number of neurodegenerative diseases.
Biomedicine. --- Neurosciences. --- Cell Biology. --- Developmental Biology. --- Medicine. --- Cytology. --- Developmental biology. --- Médecine --- Neurosciences --- Cytologie --- Biologie du développement --- Cyclin-Dependent Kinases -- antagonists and inhibitors. --- Cyclin-dependent kinases -- Inhibitors -- Therapeutic use. --- Cyclin-Dependent Kinases -- therapeutic use. --- Cyclin-dependent kinases. --- Nervous system -- Degeneration -- Etiology. --- Nervous system -- Degeneration -- Treatment. --- Neurodegenerative Diseases -- drug therapy. --- Nervous System Diseases --- Cell Cycle Proteins --- Proline-Directed Protein Kinases --- Intracellular Signaling Peptides and Proteins --- Protein-Serine-Threonine Kinases --- Proteins --- Diseases --- Peptides --- Protein Kinases --- Phosphotransferases (Alcohol Group Acceptor) --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Phosphotransferases --- Transferases --- Enzymes --- Enzymes and Coenzymes --- Cyclin-Dependent Kinases --- Neurodegenerative Diseases --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Animal Biochemistry --- Neurology --- Cyclin-dependent kinases --- Nervous system --- Inhibitors --- Therapeutic use. --- Degeneration --- Etiology. --- Treatment. --- CDK proteins --- Cyclin-dependent protein kinases --- Cell biology. --- Organs (Anatomy) --- Protein kinases --- Development (Biology) --- Biology --- Growth --- Ontogeny --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences
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Cell Cycle Control and Plant Development commences with an introductory chapter and is broadly divided into two parts. Part 1 details the basic cell machinery, with chapters covering cyclin-dependent kinases (CDKs), cyclins, CDK inhibitors, proteolysis, CDK phosphorylation, and E2F/DP transcription factors. Part 2, which describes the cell cycle and plant development, covers cell cycle activation, cell cycle control during leaf development, endoreduplication, the cell cycle and trichome, fruit and endosperm development, the hormonal control of cell division and environmental stress, and cell cycle exit.
Plant cell cycle. --- Cyclin-dependent kinases. --- Plant cells and tissues --- Plantes --- Kinases dépendantes des cyclines --- Growth --- Regulation. --- Cycle cellulaire --- Cellules et tissus --- Croissance --- Régularisation --- Plant cell cycle --- Cyclin-dependent kinases --- Regulation --- Plante --- plants --- Développement biologique --- biological development --- Différenciation cellulaire --- Cell differentiation --- Développement saisonnier --- Seasonal development --- Physiologie végétale --- Plant physiology --- Phosphorylation --- Transcription --- transcription --- Expression des gènes --- gene expression --- Mécanisme de défense --- Defence mechanisms --- Protéine recombinante --- Recombinant proteins --- Auxine --- Auxins --- 581.17 --- 581.14 --- Physiology of the cell --- Development --- 581.14 Development --- 581.17 Physiology of the cell --- Kinases dépendantes des cyclines --- Régularisation --- Plant tissues --- Cells --- Plant anatomy --- Tissues --- Biological rhythms in plants --- Cell cycle --- CDK proteins --- Cyclin-dependent protein kinases --- Protein kinases --- Growth&delete& --- transcription. --- Plant cells and tissues - Growth - Regulation
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