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This book is an evaluation of heart rate variability (HRV), the tendency for the heart rate to oscillate, increasing and decreasing depending on a number of factors. Such oscillations can give information on the state of the complex systems involved and can reveal a higher mortality risk. The author discusses the basic functional structures responsible for HRV and the evidence for this. In addition, the book provides a framework to understand HRV within the perspective of systems biology and presents basic principles and related mathematical models. Heart Rate Variability provides a thorough investigation of the clinical aspects of the concept, defining the level of risk, the practical management algorithms and clarification of the common mechanisms, such as heart rate turbulence. As such, this book will be of interest to all involved in the research and management of all the cardiovascular conditions related to this phenomenon.

Heart beat. --- Arrhythmia. --- Allorhythmia --- Arhythmia --- Arrhythmias --- Cardiac arrhythmia --- Dysrhythmia --- Irregular heart beats --- Cardiac cycle --- Cycle, Cardiac --- Heart cycle --- Heart rate --- Medicine. --- Cardiology. --- Medicine & Public Health. --- Heart --- Heart beat --- Electric countershock --- Palpitation --- Heart conduction system --- Hemodynamics --- Pulse --- Diseases --- Contraction --- Internal medicine

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The Poincaré plot (named after Henri Poincaré) is a popular two-dimensional visualization tool for dynamic systems due to its intuitive display of the dynamic properties of a system from a time series. This book presents the basis of Poincaré plot and focus especially on traditional and new methods for analysing the geometry, temporal and spatial dynamics disclosed by the Poincaré plot to evaluate heart rate variability (HRV). Mathematical descriptors of Poincaré plot have been developed to quantify the autonomic nervous system activity (sympathetic and parasympathetic modulation of heart rate). Poincaré plot analysis has also been used in various clinical diagnostic settings like diabetes, chronic heart failure, chronic renal failure and sleep apnea syndrome. The primary aims of quantification of the Poincaré plots are to discriminate healthy physiological systems from pathological conditions and to classify the stage of a disease. The HRV analysis by Poincaré plot has opened up ample opportunities for important clinical and research applications. Therefore, the present book can be used either for self-study, as a supplement to courses in linear and nonlinear systems, or as a modern monograph by researchers in this field of HRV analysis.

Biomedical engineering. --- Cardiology. --- Heart -- Pathophysiology. --- Heart beat. --- Heart Rate. --- Heart. --- Medicine. --- Pulse. --- Medicine --- Health & Biological Sciences --- Cardiovascular Diseases --- Heart rate monitoring. --- Heart beat --- Mathematical models. --- Cardiac cycle --- Cycle, Cardiac --- Heart cycle --- Heart rate --- Medicine & Public Health. --- Biomedical Engineering. --- Heart --- Heart conduction system --- Hemodynamics --- Pulse --- Cardiography --- Patient monitoring --- Contraction --- Biomedical Engineering and Bioengineering. --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Internal medicine --- Diseases --- Diagnosis.

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This book introduces readers to the basic concepts of Heart Rate Variability (HRV) and its most important analysis algorithms using a hands-on approach based on the open-source RHRV software. HRV refers to the variation over time of the intervals between consecutive heartbeats. Despite its apparent simplicity, HRV is one of the most important markers of the autonomic nervous system activity and it has been recognized as a useful predictor of several pathologies. The book discusses all the basic HRV topics, including the physiological contributions to HRV, clinical applications, HRV data acquisition, HRV data manipulation and HRV analysis using time-domain, frequency-domain, time-frequency, nonlinear and fractal techniques. Detailed examples based on real data sets are provided throughout the book to illustrate the algorithms and discuss the physiological implications of the results. Offering a comprehensive guide to analyzing beat information with RHRV, the book is intended for masters and Ph.D. students in various disciplines such as biomedical engineering, human and veterinary medicine, biology, and pharmacy, as well as researchers conducting heart rate variability analyses on both human and animal data.

Statistics. --- Cardiac imaging. --- Cardiology. --- Biostatistics. --- Biomedical engineering. --- Statistics for Life Sciences, Medicine, Health Sciences. --- Signal, Image and Speech Processing. --- Biomedical Engineering. --- Cardiac Imaging. --- Clinical engineering --- Medical engineering --- Biological statistics --- Biology --- Biometrics (Biology) --- Biostatistics --- Cardiac diagnostic imaging --- Cardiac imaging --- Diagnostic cardiac imaging --- Heart --- Imaging of the heart --- Statistical analysis --- Statistical data --- Statistical methods --- Statistical science --- Diseases --- Imaging --- Statistical methods. --- Heart beat. --- Internal medicine --- Cardiac cycle --- Cycle, Cardiac --- Heart cycle --- Heart rate --- Heart conduction system --- Hemodynamics --- Pulse --- Contraction --- Biomedical Engineering and Bioengineering. --- Mathematics --- Econometrics --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Statistics . --- Signal processing. --- Image processing. --- Speech processing systems. --- Biomathematics --- Statistics --- Computational linguistics --- Electronic systems --- Information theory --- Modulation theory --- Oral communication --- Speech --- Telecommunication --- Singing voice synthesizers --- Pictorial data processing --- Picture processing --- Processing, Image --- Imaging systems --- Optical data processing --- Processing, Signal --- Information measurement --- Signal theory (Telecommunication) --- R (Computer program language). --- GNU-S (Computer program language) --- Domain-specific programming languages

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Pathological heart rhythms are a major health issue. In this book experts from various fields provide an important context for understanding the complicated molecular and cellular mechanisms that underlie normal and pathophysiological cardiac rhythms. Individual chapters cover a full range of topics, including the ionic basis of pacemaking, the role of specific channels and transporters in sinoatrial node pacemaking, altered intracellular Ca2+ handling in response to disease, computer modeling of the action potentials of pacemaker and working cardiomyocytes, genetic and molecular basis of inherited arrhythmias and a review of established and novel antiarrhythmic agents. Due to the key importance of the specialized pacemaker cells and tissue (sinoatrial and atrioventricular nodes) in maintaining heart rate and rhythm, special emphasis is placed on the peculiar electrophysiology of these cells.

Cardiology. --- Human physiology. --- Medicine. --- Toxicology. --- Heart --- Cardiovascular Agents --- Membrane Glycoproteins --- Pathologic Processes --- Vital Signs --- Hemodynamics --- Heart Diseases --- Membrane Transport Proteins --- Membrane Proteins --- Cardiovascular Physiological Phenomena --- Cardiovascular Diseases --- Pathological Conditions, Signs and Symptoms --- Physical Examination --- Cardiovascular System --- Therapeutic Uses --- Carrier Proteins --- Diagnostic Techniques and Procedures --- Diseases --- Proteins --- Circulatory and Respiratory Physiological Phenomena --- Anatomy --- Pharmacologic Actions --- Amino Acids, Peptides, and Proteins --- Chemical Actions and Uses --- Phenomena and Processes --- Diagnosis --- Chemicals and Drugs --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Ion Channels --- Heart Rate --- Heart Conduction System --- Arrhythmias, Cardiac --- Anti-Arrhythmia Agents --- Medicine --- Biology --- Health & Biological Sciences --- Biophysics --- Heart beat. --- Arrhythmia. --- Allorhythmia --- Arhythmia --- Arrhythmias --- Cardiac arrhythmia --- Dysrhythmia --- Irregular heart beats --- Cardiac cycle --- Cycle, Cardiac --- Heart cycle --- Heart rate --- Molecular biology. --- Pharmacology. --- Biomedicine. --- Molecular Medicine. --- Human Physiology. --- Pharmacology/Toxicology. --- Heart beat --- Electric countershock --- Palpitation --- Heart conduction system --- Pulse --- Contraction --- Internal medicine --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Human biology --- Medical sciences --- Physiology --- Human body --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Toxicology --- Health Workforce --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biomolecules --- Systems biology --- Physiological effect