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Crystallography --- Cristallographie --- Congresses --- Congrès --- Crystallography - Congresses
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Cristall chemistry --- fysicochemie --- Crystallography --- Crystal growth --- Congresses --- Crystal chemistry --- Crystallography - Congresses --- Crystal growth - Congresses
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Crystallography --- Inorganic compounds --- Cristallographie --- Congresses --- Congrès --- Congresses. --- Crystallography - Congresses. --- Inorganic compounds - Congresses.
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Crystallography --- Drugs --- Drug Design --- Models, Molecular --- Protein Engineering --- Research --- Mathematical models --- methods --- Pharmacology --- Congresses --- Crystallography - Congresses --- Drugs - Research - Congresses --- Drugs - Mathematical models - Congresses --- Crystallography - methods - congresses --- Drug Design - Congresses --- Models, Molecular - Congresses --- Protein Engineering - Congresses
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This book of the proceedings of the 1997 NATO Advanced Study Institute (ASI) on Direct Methods for Solving Macromolecular Structures was assembled from the lecturers' contributions and represents a comprehensive and in-depth overview of crystallographic structure determination methods for macromolecules. While having a focus based on the direct methods, the Institute adopted an inclusive and broad perspective. Thus, both direct and experimental phasing techniques are presented in this book, highlighting their complementarities and synergies. As weil, methodologies spanning the full crystallographic image reconstruction process - from low resolution envelope definition to high resolution atomic refinement- are discussed. The first part of the book introduces the array of tools currently used in structure determination, whether originating from a mathematical, computational or experimental framework. This section of the book displays the variety and ingenuity of old and new phasing approaches developed to solve increasingly complex structures. Some of the contributions focus on recent developments and/or implementations that have given older approaches a new life. A case in point is the re-implementation of Buerger's superposition approach, which is now solving protein structures. Another beautiful example is found in the introduction to the traditional multiple isomorphous replacement approach where new techniques, such as site-directed mutagenesis and the use of inert gases in the preparation of heavy atom derivatives, are described. Equally impressive are the presentations of newer approaches, which take advantage of advances on the experimental front (e. g.
Macromolecules --- Crystallography --- Structure --- Congresses --- Crystallography. --- Biochemistry. --- Physical chemistry. --- Crystallography and Scattering Methods. --- Biochemistry, general. --- Physical Chemistry. --- Chemistry, Theoretical --- Physical chemistry --- Theoretical chemistry --- Chemistry --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Leptology --- Physical sciences --- Mineralogy --- Composition --- Molecules --- Supramolecular chemistry --- Macromolecules - Structure - Congresses --- Crystallography - Congresses
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Structure-Based Drug Design brings together scientists working on different aspects of the subject, demonstrating the necessary collaboration and interdisciplinary approach to this complex area. The focus is on X-ray crystallographic and computational approaches. The general aspects of these approaches are introduced in the first six articles. The remaining articles provide examples of the application of X-ray crystallography, molecular modelling, molecular dynamics, QSAR, database analysis, and homology modelling. The papers cover a wealth of interesting problems in the design of new and enhanced pharmaceuticals.
Drugs --- X-ray crystallography --- Structure-activity relationships --- Congresses --- Design --- Computer simulation --- Physical chemistry. --- Chemistry, Physical and theoretical. --- Biochemistry. --- Physical Chemistry. --- Theoretical and Computational Chemistry. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Chemistry, Theoretical --- Physical chemistry --- Theoretical chemistry --- Composition --- Drugs - Structure-activity relationships - Congresses --- Drugs - Design - Computer simulation - Congresses --- X-ray crystallography - Congresses
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Aperiodic Crystals collects 37 selected papers from the scientific contributions presented at Aperiodic 2012 - the Seventh International Conference on Aperiodic Crystals held in Cairns, Australia, 2-7 of September 2012. The volume discusses state-of-the-art discoveries, new trends and applications of aperiodic crystals - including incommensurately modulated crystals, composite crystals, and quasicrystals - from a wide range of different perspectives. Starting with a general historical introduction to aperiodic crystals, the book proceeds to examine the complex mathematics of aperiodic long-range order, as well as the theoretical approaches aimed at understanding some of the unique properties and mechanisms underlying the existence of aperiodic crystals. The book then explores in detail such topics as complex metallic alloys, modulated structures, quasicrystals and their approximants, dynamics, disorder and defects in quasicrystals. It concludes with an analysis of quasicrystal surfaces and their properties. By describing the latest research and the progress made on the structure determination of aperiodic crystals and the influence of this unique structure on their physical properties, this book represents a valuable resource to mathematicians, crystallographers, physicists, chemists, materials and surface scientists, and even architects and artists, interested in the fascinating nature of aperiodic crystals.
Aperiodicity -- Congresses. --- Crystallography -- Congresses. --- Quasicrystals -- Congresses. --- Crystals. --- Quasicrystals. --- Quasi-crystals --- Materials science. --- Spectroscopy. --- Crystallography. --- Structural materials. --- Materials Science. --- Structural Materials. --- Spectroscopy/Spectrometry. --- Condensed matter --- Crystals --- Crystallography --- Powders --- Solids --- Materials. --- Crystallography and Scattering Methods. --- Analysis, Spectrum --- Spectra --- Spectrochemical analysis --- Spectrochemistry --- Spectroscopy --- Chemistry, Analytic --- Interferometry --- Optics --- Radiation --- Wave-motion, Theory of --- Absorption spectra --- Light --- Spectroscope --- Leptology --- Physical sciences --- Mineralogy --- Engineering --- Engineering materials --- Industrial materials --- Engineering design --- Manufacturing processes --- Qualitative --- Materials --- Spectrometry --- Architectural materials --- Architecture --- Building --- Building supplies --- Buildings --- Construction materials --- Structural materials --- Analytical chemistry --- Quasicrystals --- Aperiodicity
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