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Corynebacterium glutamicum was discovered in Japan in 1956 as a natural glutamate producer. Its “microbial factory” qualities, such as its physiological plasticity and robust catalytic functionalities, have since facilitated the development of efficient production processes for amino acids, nucleotides and vitamins. This monograph illustrates how the information gleaned from complete genome sequencing allows the rational engineering of the entire cellular metabolism and how systems biology permits the further optimization of C. glutamicum as a biocatalyst. Aspects of gene regulation, metabolic pathways, sugar uptake, protein secretion, cell division and biorefinery applications highlight the enormous biotechnological and biorefinery potential.
Amino acids -- Biotechnology -- Handbooks, manuals, etc. --- Corynebacterium glutamicum -- Handbooks, manuals, etc. --- Glutamic acid -- Biotechnology -- Handbooks, manuals, etc. --- Corynebacterium glutamicum --- Technology --- Corynebacterium --- Biological Science Disciplines --- Natural Science Disciplines --- Technology, Industry, and Agriculture --- Actinomycetales --- Gram-Positive Asporogenous Rods, Irregular --- Gram-Positive Asporogenous Rods --- Technology, Industry, Agriculture --- Actinobacteria --- Disciplines and Occupations --- Gram-Positive Rods --- Gram-Positive Bacteria --- Bacteria --- Organisms --- Biotechnology --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Corynebacterium glutamicum. --- Corynebacterium. --- Corynebacterium lilium --- Micrococcus glutamicus --- Life sciences. --- Biotechnology. --- Microbiology. --- Biochemistry. --- Life Sciences. --- Applied Microbiology. --- Biochemistry, general. --- Corynebacteriaceae --- Biological chemistry --- Chemical composition of organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Chemical engineering --- Genetic engineering --- Microbial biology --- Microorganisms --- Composition
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This updated second edition covers the molecular biology, genome engineering tools and comprehensive analysis techniques for Corynebacterium glutamicum. Aside from modern omics-based approaches, the authors also focus on cell physiology, including cell division, central carbon metabolic pathways, and the respiratory chain. Readers will learn how primary mechanisms like energy metabolism can be applied in processes like biorefinery. Newly added topics include cell envelope structures and aromatic compound metabolism in C. glutamicum. These chapters will be particularly useful for those interested in the microbial production of commodity chemicals, fuels, and proteins. Corynebacteriacea are already some of the most important industrial microorganisms. Understanding the cell physiology of C. glutamicum will help manufacturers to increase their product range and productivity through efficient metabolic engineering.
Microbiology. --- Biochemistry. --- Applied Microbiology. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Microbial biology --- Microorganisms --- Composition --- Corynebacterium glutamicum. --- Corynebacterium lilium --- Micrococcus glutamicus --- Corynebacterium --- Corynebacterium glutamicum --- Bacteris --- Enginyeria genètica --- Biologia molecular --- Biofísica molecular --- Bioquímica molecular --- Biofísica --- Bioquímica --- Histoquímica --- Biologia molecular vegetal --- Codi genètic --- Diagnòstic molecular --- Endocrinologia molecular --- Evolució molecular --- Farmacologia molecular --- Genètica molecular --- Glicòmica --- Metabolòmica --- Microbiologia molecular --- Neurobiologia molecular --- Patologia molecular --- Proteòmica --- Reconeixement molecular --- Biomolècules --- Intervenció genètica --- Manipulació genètica --- Recombinació genètica --- ADN recombinant --- Clonatge --- Clonatge molecular --- Enginyeria de proteïnes --- Enginyeria genètica animal --- Enginyeria genètica vegetal --- Teràpia genètica --- Fecundació in vitro --- Organismes transgènics --- Microbis --- Microorganismes --- Antígens bacterians --- Bacteris anaerobis --- Bacteris fotosintetitzadors --- Bacteris gramnegatius --- Bacteris nitrificants --- Bacteris patògens --- Lactobacils --- Listeria --- Virus
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