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Insights into the regulation of immune cell lineage differentiation and specification as well as into the control of lineage integrity, stability and plasticity are of fundamental importance to understanding innate and adaptive immune responses. In this volume, leading experts provide an up-to-date and comprehensive overview of recent advances in the transcriptional control mechanisms and transcription factor networks that regulate these processes in a variety of different immune cell lineages. The chapters cover the regulation of T versus B cell lineage choice, discuss early B cell development and pre-B cell leukemia prevention, address transcriptional control mechanisms during Th differentiation, in regulatory T cells and iNKT cells, detail genomic switches in helper cell fate choice and plasticity, and highlight the role of the BTB-zinc finger family of transcription factors in T cells. Moreover, the chapters discuss transcriptional networks in DCs, NK cells and in innate lymphoid cells. Together, the reviews illustrate key transcriptional control mechanisms that regulate the development and function of immune cells and demonstrate the impressive advances made over the last decade.

Blood cells. --- Blood --- Blood corpuscles --- Corpuscles, Blood --- Haemocytes --- Hemic cells --- Hemocytes --- Cells --- Corpuscles and platelets --- Immunology. --- Immunobiology --- Life sciences --- Serology

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Blood transfusion.

Blood cells. --- Blood. --- Body fluids --- Fear of blood --- Blood --- Blood corpuscles --- Corpuscles, Blood --- Haemocytes --- Hemic cells --- Hemocytes --- Cells --- Corpuscles and platelets

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Immune system. --- Hematopoiesis. --- Blood cells. --- Blood --- Blood corpuscles --- Corpuscles, Blood --- Haemocytes --- Hemic cells --- Hemocytes --- Cells --- Blood formation --- Hemopoiesis --- Immunological system --- Anatomy --- Immunology --- Corpuscles and platelets --- Immune System. --- Immune Systems --- System, Immune --- Systems, Immune

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In recent years, great progress has been made in the identification of the molecular players involved in the epigenetic control of gene expression during development. The work of many laboratories has established that regulating the interplay of transcription factors with chromatin components is the major driver of cellular differentiation. Because of their single cell nature and ease of purification, much of what we have learnt about these processes in animals has been delivered based on cellular models within the hematopoietic system. The blood cell system evolved from a few simple cell types in more primitive organisms that provide oxygen transport and carry out phagocytosis into the complex hematopoietic system of mammals, containing many specialized cells types with vastly different functions, such as B cells, T cells, granulocytes, macrophages, erythrocytes, and megakaryocytes. This book describes the intricate processes involved in the development of blood cells across a range of organisms from drosophila and fish at one end, and mammals at the other end. It contains individual chapters devoted to describing the epigenetic and transcriptional mechanisms regulating hematopoiesis in the different organisms and orchestrating the differentiation of a wide variety of cell types. Different chapters describe the function of lymphocytes, macrophages and red blood cells and the molecular players, i.e. transcription factors and the epigenetic regulatory machinery driving their differentiation. Most importantly, the book not only describes normal processes, such as the rearrangements of antigen receptor genes, and the regulation of genes by various mechanisms such as DNA methylation, but also outlines what happens when these processes function abnormally to precipitate diseases such as leukemia and immune disorders.

Epigenetics. --- Blood cells. --- Blood --- Biomedicine. --- Human genetics. --- Cancer --- Diseases. --- Research. --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Cancer research --- Clinical hematology --- Hematologic diseases --- Hematology --- Blood corpuscles --- Corpuscles, Blood --- Haemocytes --- Hemic cells --- Hemocytes --- Cells --- Corpuscles and platelets --- Oncology. --- Human Genetics. --- Cancer Research. --- Tumors --- Cancer research.

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Tryptophan metabolism --- Biological transport --- Blood cells --- Neurons --- Blood-brain barrier --- Tryptophan --- Congresses. --- Metabolism --- Drug effects --- Blood --- Blood corpuscles --- Corpuscles, Blood --- Haemocytes --- Hemic cells --- Hemocytes --- Cells --- Blood-cerebral barrier --- Blood-cerebrospinal fluid barrier --- Brain-blood barrier --- Hemato-encephalic barrier --- Hematoencephalic barrier --- Brain --- Cerebrospinal fluid --- Choroid plexus --- Congresses --- Corpuscles and platelets --- Blood-vessels