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The editor has incorporated scientific contributions from a diverse group of leading researchers in the field of hematology and related blood cell research. This book aims to provide an overview of current knowledge pertaining to our understanding of hematology. The main subject areas will include blood cell morphology and function, the pathophysiology and genetics of hematological disorders and malignancies, blood testing and typing, and the processes governing hematopoiesis. Blood cell physiology, biochemistry and blood flow are covered in this book. This text is designed for hematologists, pathologists and laboratory staff in training and in practice. The work presented in this book will be of benefit to medical students and to researchers of hematology and blood flow in the microcirculation.This book is written primarily for those who have some knowledge of chemistry, biochemistry and general hematology. The authors of each section bring a strong clinical emphasis to the book.

Blood cells. --- Blood --- Blood corpuscles --- Corpuscles, Blood --- Haemocytes --- Hemic cells --- Hemocytes --- Cells --- Corpuscles and platelets --- Haematology

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Leukemia. --- Blood cells. --- Blood --- Blood corpuscles --- Corpuscles, Blood --- Haemocytes --- Hemic cells --- Hemocytes --- Cells --- Leucaemia --- Leucemia --- Leucocythaemia --- Leucocythemia --- Leucosis --- Leukaemia --- Leukosis --- Anemia --- Cancer --- Leucocytosis --- Preleukemia --- Corpuscles and platelets

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Human histology. Human cytology --- Blood Cells --- Blood Cells. --- Blood Corpuscles --- Blood Cell --- Blood Corpuscle --- Cell, Blood --- Cells, Blood --- Corpuscle, Blood --- Corpuscles, Blood --- Blood --- ultrastructure. --- cytology --- BLOOD CELLS --- Blood cells --- ultrastructure --- Blood cells. --- Ultrastructure.

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Immune system. --- Hematopoiesis. --- Blood cells. --- Blood --- Blood corpuscles --- Corpuscles, Blood --- Haemocytes --- Hemic cells --- Hemocytes --- Cells --- Blood formation --- Hemopoiesis --- Immunological system --- Anatomy --- Immunology --- Corpuscles and platelets --- Immune System. --- Immune Systems --- System, Immune --- Systems, Immune

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In recent years, great progress has been made in the identification of the molecular players involved in the epigenetic control of gene expression during development. The work of many laboratories has established that regulating the interplay of transcription factors with chromatin components is the major driver of cellular differentiation. Because of their single cell nature and ease of purification, much of what we have learnt about these processes in animals has been delivered based on cellular models within the hematopoietic system. The blood cell system evolved from a few simple cell types in more primitive organisms that provide oxygen transport and carry out phagocytosis into the complex hematopoietic system of mammals, containing many specialized cells types with vastly different functions, such as B cells, T cells, granulocytes, macrophages, erythrocytes, and megakaryocytes. This book describes the intricate processes involved in the development of blood cells across a range of organisms from drosophila and fish at one end, and mammals at the other end. It contains individual chapters devoted to describing the epigenetic and transcriptional mechanisms regulating hematopoiesis in the different organisms and orchestrating the differentiation of a wide variety of cell types. Different chapters describe the function of lymphocytes, macrophages and red blood cells and the molecular players, i.e. transcription factors and the epigenetic regulatory machinery driving their differentiation. Most importantly, the book not only describes normal processes, such as the rearrangements of antigen receptor genes, and the regulation of genes by various mechanisms such as DNA methylation, but also outlines what happens when these processes function abnormally to precipitate diseases such as leukemia and immune disorders.

Epigenetics. --- Blood cells. --- Blood --- Biomedicine. --- Human genetics. --- Cancer --- Diseases. --- Research. --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Cancer research --- Clinical hematology --- Hematologic diseases --- Hematology --- Blood corpuscles --- Corpuscles, Blood --- Haemocytes --- Hemic cells --- Hemocytes --- Cells --- Corpuscles and platelets --- Oncology. --- Human Genetics. --- Cancer Research. --- Tumors --- Cancer research.