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Hematopoietic stem cells (HSCs)--from bone marrow, peripheral blood, or umbilical cord blood--are used to treat patients with cancers such as leukemia or lymphoma, disorders of the blood and immune systems, severe aplastic anemia, sickle cell disease, and certain inherited metabolic diseases. In addition to cord blood's direct therapeutic value to patients, it is also used for basic research on blood, blood stem cells, and immune cells. In recent years, the U.S. government (through the Health Resources and Services Administration) has endeavored to increase the overall national inventory--which currently contains over 200,000 units--as well as the number of high-quality units and the number of units from racial/ethnic minorities. Despite the important clinical and research roles of cord blood products and a clear public health need for increasing and diversifying our national inventory, little is systematically known about the economics of the industry, including what banks' costs and revenues are, cost structures and determinants of financial health, successful collection efforts for cord blood banks (CBBs), whether the market is competitive or similar to a public goods market, and the role of the government in the market. In this report, we aim to fill these knowledge gaps by (1) describing the existing public CBB system, (2) assessing current trends and economic relationships from the perspective of key stakeholders in the public CBB system, and (3) providing recommendations to improve the economic sustainability of the public CBB system.

Fetal blood --- Blood banks --- Fetal Blood. --- Cord Blood Stem Cell Transplantation. --- Blood Banks --- Economic aspects --- economics. --- United States.

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Blood Banks --- Blood Grouping and Crossmatching --- Blood banks. --- Cord Blood Stem Cell Transplantation --- Fetal blood --- Hematopoietic Stem Cell Transplantation --- Hematopoietic Stem Cell Transplantation --- Hematopoietic Stem Cell Transplantation --- Hematopoietic stem cells. --- Organization & administration. --- Standards. --- Standards. --- Transplantation. --- Ethics. --- Legislation & jurisprudence. --- Standards.

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Since the first successful transplantation of umbilical cord blood in 1988, cord blood has become an important source of hematopoietic stem and progenitor cells for the treatment of blood and genetic disorders. Significant progress has been accompanied by challenges for scientists, ethicists, and health policy makers. With the recognition of the need for a national system for the collection, banking, distribution, and use of cord blood and the increasing focus on cord blood as an alternative to embryos as a source of tissue for regenerative medicine, it has garnered significant attention recently. Frontiers in Cord Blood Science contains chapters from distinguished investigators currently engaged in researching cord blood in the treatment of various diseases of the brain, heart, liver, pancreas, bone and cartilage. The current state of research in the field is presented and the potential future applications of cord blood both for research and for the treatment of different diseases and conditions is discussed. In addition, the book reviews the possibility for novel uses in surgical wound healing and in synthetic grafts for reconstructive surgery, allowing their better adhesion. Investigating the ethical issues, this book will be of interest to all scientists and researchers within the field of regenerative medicine and also clinicians in dermatology, neurology, cardiology and orthopedics wishing to discover more about the potential for the revolutionary medical approach of human umbilical cord blood.

Ethics, Medical. --- Ethics, Research. --- Stem cells -- Research -- Moral and ethical aspects. --- Stem Cells. --- Fetal blood --- Stem cells --- Blood --- Stem Cell Transplantation --- Biological Specimen Banks --- Cells --- Fetus --- Health Facilities --- Hemic and Immune Systems --- Anatomy --- Cell Transplantation --- Body Fluids --- Embryonic Structures --- Health Care Facilities, Manpower, and Services --- Transplantation --- Fluids and Secretions --- Health Care --- Surgical Procedures, Operative --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Stem Cells --- Cord Blood Stem Cell Transplantation --- Fetal Blood --- Tissue Banks --- Medicine --- Health & Biological Sciences --- Hematologic Diseases --- Pathology --- Gynecology & Obstetrics --- Therapeutic use --- Fetal blood. --- Stem cells. --- Therapeutic use. --- Transplantation. --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cord blood --- Umbilical cord blood --- Stem cell transplantation --- Medicine. --- Gene therapy. --- Internal medicine. --- Blood transfusion. --- Hematology. --- Surgical transplantation. --- Medicine & Public Health. --- Gene Therapy. --- Blood Transfusion Medicine. --- Transplant Surgery. --- Internal Medicine. --- Cell transplantation