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At the core of this book lies the question how to approach medicines, risks and communication as a researcher - or anybody planning and evaluating a communication intervention, or wanting to understand communication events in private and the media. With a view to tackle current shortcomings of communication systems and processes for improved implementation, patient satisfaction and health outcomes, a multilayered approach is presented. This combines multiple data types and methods to obtain a wider and deeper understanding of the major parties and their interactions, as well as the healthcare, social and political contexts of information flows, how they interfere and which impact they have. Illustrated with real life experiences of safety concerns with medicines, worldwide active experts discuss the methods and contributions their disciplines can offer. With considerations on terminologies, tabulated overviews on communication types and outcomes, a patient-centred vision and plain language for non-medical readers, the book creates a platform for multidisciplinary collaborations amongst researchers as well as practitioners from communications, healthcare, the social sciences and pharmacovigilance. Importantly, it advocates for an active role of patients and highlights the achievements and aspirations of patient organisations. Finally, the book suggests establishing an inclusive discipline of humanities and epidemiology of medicinal product risk communication to realise full research potential. The authors are driven by the curiosity for communication as the most human behaviour, and as good health is amongst the basic human needs, medicinal product risk communication is an exciting research field of high global relevance.

Communication in pharmacy. --- Drugs. --- Medicaments --- Medications --- Medicine (Drugs) --- Medicines (Drugs) --- Pharmaceuticals --- Prescription drugs --- Bioactive compounds --- Medical supplies --- Pharmacopoeias --- Chemotherapy --- Materia medica --- Pharmacology --- Pharmacy --- Pharmaceutical communication --- Pharmacy. --- Drug Safety and Pharmacovigilance. --- Chemistry --- Medicine --- Drugs --- Avaluació del risc per la salut --- Comunicació en farmàcia --- Anàlisi del risc sanitari --- Avaluació del risc sanitari --- Risc sanitari --- Seguretat sanitària --- Avaluació del risc --- Salut pública --- Cribratge --- Higiene ambiental --- Medicina preventiva --- Comunicació farmacèutica --- Farmàcia --- Fàrmacs --- Medicines --- Farmacopees --- Química farmacèutica --- Compostos bioactius --- Accés als medicaments --- Afrodisíacs --- Agents antilipèmics --- Antidiabètics --- Botànica mèdica --- Conservació de medicaments --- Contraceptius --- Diürètics --- Envasament de medicaments --- Excipients --- Farmacognòsia --- Farmacologia cardiovascular --- Interaccions dels medicaments --- Medicaments antineoplàstics --- Medicaments cardiovasculars --- Medicaments congelats --- Medicaments liofilitzats --- Medicaments orfes --- Medicaments peptídics --- Medicaments respiratoris --- Microbiologia farmacèutica --- Psicofàrmacs --- Prescripció de medicaments --- Preu dels medicaments --- Relaxants musculars --- Administració de medicaments --- Farmacologia --- Matèria mèdica --- Quimioteràpia --- Validació (Medicaments)

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This book offers comprehensive information on the new and rapidly evolving science of identifying and targeting senescent cells, and on the exciting prospect of new diagnostic and therapeutic opportunities for stopping, and even reversing, the progression of disease and the deterioration of the human body due to ageing. According to recent United Nations data, by 2050 one in six people worldwide will be older than age 65, with peaks rising to one in four people in Europe and North America. Remarkably, the number of persons aged 80 years or older is expected to triple, from 143 million in 2019 to 426 million in 2050. First documented in the 1960s, the concept of cellular senescence as an underlying cause of ageing has been established in the course of the last decade. Using genetically engineered mouse models, researchers have demonstrated that the selective elimination of senescent cells can block and even reverse a number of age-related dysfunctions and pathologies, promoting both better health and longer life in the elderly. These include cardiovascular diseases; neurological disorders; type 1 and type 2 diabetes; inflammatory diseases; fibrosis; geriatric syndromes; chronic diseases resulting in organ dysfunction; the integrity of the musculoskeletal system; and cancer. Some senolytic agents have already progressed into trials. These include UBX0101 for the treatment of osteoarthritis (now in phase II), a cocktail of dasatinib and quercetin for the management of idiopathic pulmonary fibrosis and chronic kidney disease, and ABT-263 in combination with senescence-inducing chemotherapies for the treatment of advanced solid tumours. In addition, the book discusses pathways to early phase clinical trials and translational approaches in medicine and ageing, highlighting new opportunities as well as current limitations, challenges and alternatives. Given its scope, it will benefit a broad audience of advanced educators, researchers, graduate students and practitioners.

Cells --- Aging. --- Aging --- Developmental biology. --- Regenerative medicine. --- Tissue engineering. --- Animal models in research. --- Molecular biology. --- Biogerontology. --- Regenerative Medicine/Tissue Engineering. --- Animal Models. --- Molecular Medicine. --- Biomedical engineering --- Regenerative medicine --- Tissue culture --- Medicine --- Regeneration (Biology) --- Development (Biology) --- Biology --- Growth --- Ontogeny --- Age --- Ageing --- Senescence --- Developmental biology --- Gerontology --- Longevity --- Age factors in disease --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Animal experimentation --- Biological models --- Laboratory animals --- Research --- Physiological effect --- Medicaments --- Demència senil --- Demència --- Malaltia d'Alzheimer --- Envelliment cerebral --- Fàrmacs --- Medicines --- Farmacopees --- Química farmacèutica --- Compostos bioactius --- Accés als medicaments --- Afrodisíacs --- Agents antilipèmics --- Antidiabètics --- Botànica mèdica --- Conservació de medicaments --- Contraceptius --- Diürètics --- Envasament de medicaments --- Excipients --- Farmacognòsia --- Farmacologia cardiovascular --- Interaccions dels medicaments --- Medicaments antineoplàstics --- Medicaments cardiovasculars --- Medicaments congelats --- Medicaments liofilitzats --- Medicaments orfes --- Medicaments peptídics --- Medicaments respiratoris --- Microbiologia farmacèutica --- Psicofàrmacs --- Prescripció de medicaments --- Preu dels medicaments --- Relaxants musculars --- Administració de medicaments --- Farmàcia --- Farmacologia --- Matèria mèdica --- Quimioteràpia --- Validació (Medicaments) --- Geriatrics. --- Regenerative Medicine and Tissue Engineering. --- Experimental Organisms. --- Biomedical Research. --- Technique. --- Research. --- Biological research --- Biomedical research --- Health Workforce --- Older people --- Diseases --- Health and hygiene

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Addiction Science & Clinical Practice provides a forum for clinically relevant research and perspectives that contribute to improving the quality of care for people with unhealthy alcohol, tobacco, or other drug use and addictive behaviours across a spectrum of clinical settings.

Drug abuse --- Drugs --- Toxicomanie --- Médicaments --- Treatment --- Periodicals. --- Research --- Traitement --- Périodiques --- Recherche --- Substance-Related Disorders --- Pharmacetical Preparations. --- therapy. --- Treatment. --- Research. --- United States. --- Health Sciences --- Clinical Medicine --- substance abuse --- alcohol --- tobacco --- drug abuse --- addictive behaviour --- addiction treatment --- Pharmaceutical Preparations --- Substance Addiction --- Drug Abuse --- Drug Addiction --- Drug Dependence --- Drug Habituation --- Drug Use Disorders --- Organic Mental Disorders, Substance-Induced --- Substance Abuse --- Substance Dependence --- Substance Use Disorders --- Abuse, Drug --- Abuse, Substance --- Abuses, Substance --- Addiction, Drug --- Addiction, Substance --- Dependence, Drug --- Dependence, Substance --- Disorder, Drug Use --- Disorder, Substance Use --- Drug Use Disorder --- Habituation, Drug --- Organic Mental Disorders, Substance Induced --- Substance Abuses --- Substance Use Disorder --- Medicaments --- Medications --- Medicine (Drugs) --- Medicines (Drugs) --- Pharmaceuticals --- Prescription drugs --- Drug use --- Recreational drug use --- Pharmaceutic Preparations --- Pharmaceutical Products --- Preparations, Pharmaceutical --- Preparations, Pharmaceutic --- Products, Pharmaceutical --- Pharmacology --- therapy --- ABŞ --- ABSh --- Ameerika Ühendriigid --- America --- Amerika Birlăshmish Shtatlary --- Amerika Birlăşmi Ştatları --- Amerika Birlăşmiş Ştatları --- Amerika ka Kelenyalen Jamanaw --- Amerika Qūrama Shtattary --- Amerika Qŭshma Shtatlari --- Amerika Qushma Shtattary --- Amerika --- Amerikai Egyesült Államok --- Amerikanʹ Veĭtʹsėndi︠a︡vks Shtattnė --- Amerikări Pĕrleshu̇llĕ Shtatsem --- Amerikas Forenede Stater --- Amerikayi Miatsʻyal Nahangner --- Ameriketako Estatu Batuak --- Amirika Carékat --- AQSh --- Ar. ha-B. --- Arhab --- Artsot ha-Berit --- Artzois Ha'bris --- Bí-kok --- Ē.P.A. --- EE.UU. --- Egyesült Államok --- ĒPA --- Estados Unidos --- Estados Unidos da América do Norte --- Estados Unidos de América --- Estaos Xuníos --- Estaos Xuníos d'América --- Estatos Unitos --- Estatos Unitos d'America --- Estats Units d'Amèrica --- Ètats-Unis d'Amèrica --- États-Unis d'Amérique --- Fareyniḳṭe Shṭaṭn --- Feriene Steaten --- Feriene Steaten fan Amearika --- Forente stater --- FS --- Hēnomenai Politeiai Amerikēs --- Hēnōmenes Politeies tēs Amerikēs --- Hiwsisayin Amerikayi Miatsʻeal Tērutʻiwnkʻ --- Istadus Unidus --- Jungtinės Amerikos valstybės --- Mei guo --- Mei-kuo --- Meiguo --- Mî-koet --- Miatsʻyal Nahangner --- Miguk --- Na Stàitean Aonaichte --- NSA --- S.U.A. --- SAD --- Saharat ʻAmērikā --- SASht --- Severo-Amerikanskie Shtaty --- Severo-Amerikanskie Soedinennye Shtaty --- Si︠e︡vero-Amerikanskīe Soedinennye Shtaty --- Sjedinjene Američke Države --- Soedinennye Shtaty Ameriki --- Soedinennye Shtaty Severnoĭ Ameriki --- Soedinennye Shtaty Si︠e︡vernoĭ Ameriki --- Spojené staty americké --- SShA --- Stadoù-Unanet Amerika --- Stáit Aontaithe Mheiriceá --- Stany Zjednoczone --- Stati Uniti --- Stati Uniti d'America --- Stâts Unîts --- Stâts Unîts di Americhe --- Steatyn Unnaneysit --- Steatyn Unnaneysit America --- SUA --- Sŭedineni amerikanski shtati --- Sŭedinenite shtati --- Tetã peteĩ reko Amérikagua --- U.S. --- U.S.A. --- United States of America --- Unol Daleithiau --- Unol Daleithiau America --- Unuiĝintaj Ŝtatoj de Ameriko --- US --- USA --- Usono --- Vaeinigte Staatn --- Vaeinigte Staatn vo Amerika --- Vereinigte Staaten --- Vereinigte Staaten von Amerika --- Verenigde State van Amerika --- Verenigde Staten --- VS --- VSA --- Wááshindoon Bikéyah Ałhidadiidzooígíí --- Wilāyāt al-Muttaḥidah --- Wilāyāt al-Muttaḥidah al-Amirīkīyah --- Wilāyāt al-Muttaḥidah al-Amrīkīyah --- Yhdysvallat --- Yunaeted Stet --- Yunaeted Stet blong Amerika --- ZDA --- Združene države Amerike --- Zʹi︠e︡dnani Derz︠h︡avy Ameryky --- Zjadnośone staty Ameriki --- Zluchanyi︠a︡ Shtaty Ameryki --- Zlucheni Derz︠h︡avy --- ZSA --- Prescription Drug Abuse --- Abuse, Prescription Drug --- Drug Abuse, Prescription --- Drug and Narcotic Control --- Disruptive, Impulse Control, and Conduct Disorders --- Psychoses, Alcoholic --- Social Problems --- Street Drugs --- Designer Drugs --- Behavior, Addictive --- Codependency (Psychology) --- Alcohol-Related Disorders --- Prescription Drug Misuse --- Bioactive compounds --- Medical supplies --- Pharmacopoeias --- Chemotherapy --- Materia medica --- Pharmacy --- Substance abuse --- Drug Dosage Calculations --- Pharmacetical Preparations --- AB --- America (Republic) --- Amerika (Republic) --- Amerikanʹ Veĭtʹsėndi͡avks Shtattn --- Saharat ʻAmērik --- Si͡evero-Amerikanskīe Soedinennye Shtaty --- Soedinennye Shtaty Si͡evernoĭ Ameriki --- Spojené staty americk --- Stáit Aontaithe Mheirice --- Wááshindoon Bikéyah Ałhidadiidzooígí --- Zʹi͡ednani Derz͡havy Ameryky --- Zluchanyi͡a Shtaty Ameryki --- Zlucheni Derz͡havy --- Illicit Drugs --- Codependency, Psychological --- Chemical Dependence --- Substance Use --- Chemical Dependences --- Dependence, Chemical --- Dependences, Chemical --- Substance Uses --- Use, Substance --- Pharmaceutical Preparations. --- Drug --- Pharmaceutical --- Pharmaceutical Preparation --- Pharmaceutical Product --- Preparation, Pharmaceutical --- Product, Pharmaceutical --- Spojené obce severoamerick --- Criminology. Victimology --- Human medicine --- Medicaments. --- Investigació mèdica. --- Drogoaddicció. --- Estats Units d'Amèrica. --- Abús de les drogues --- Addicció a les drogues --- Consum de drogues --- Drogodependència --- Narcoticomania --- Toxicomania --- Conducta compulsiva --- Drogues --- Abús dels medicaments --- Al·lucinògens --- Alcoholisme --- Drogoaddicció en l'embaràs --- Drogoaddictes --- Drogues i escoles --- Drogues i joventut --- Estimulants --- Opiomania --- Síndrome d'abstinència --- Desintoxicació de les drogues --- Prevenció de toxicomanies --- Investigació biomèdica --- Investigació --- Investigació farmacèutica --- Experimentació humana en medicina --- Ressenyes sistemàtiques (Investigació mèdica) --- Animals de laboratori --- Fàrmacs --- Medicines --- Farmacopees --- Química farmacèutica --- Compostos bioactius --- Accés als medicaments --- Afrodisíacs --- Agents antilipèmics --- Antidiabètics --- Botànica mèdica --- Conservació de medicaments --- Contraceptius --- Diürètics --- Envasament de medicaments --- Excipients --- Farmacognòsia --- Farmacologia cardiovascular --- Interaccions dels medicaments --- Medicaments antineoplàstics --- Medicaments cardiovasculars --- Medicaments congelats --- Medicaments liofilitzats --- Medicaments orfes --- Medicaments peptídics --- Medicaments respiratoris --- Microbiologia farmacèutica --- Psicofàrmacs --- Prescripció de medicaments --- Preu dels medicaments --- Relaxants musculars --- Administració de medicaments --- Farmàcia --- Farmacologia --- Matèria mèdica --- Quimioteràpia --- Validació (Medicaments) --- E.U.A. --- EUA --- Estados Unidos de América --- Estats Units --- United States --- Amèrica del Nord --- Alabama --- Alaska --- Arizona --- Arkansas --- Califòrnia --- Carolina del Nord --- Carolina del Sud --- Colorado --- Connecticut --- Dakota del Nord --- Dakota del Sud --- Delaware --- Florida --- Geòrgia --- Guadalupe Mountains (Estats Units d'Amèrica : Serralada) --- Hawaii --- Idaho --- Illinois --- Indiana --- Iowa --- Kansas --- Kentucky --- Louisiana --- Maine --- Maryland --- Massachusetts --- Michigan --- Minnesota --- Mississipí --- Missouri --- Montana --- Nebraska --- Nevada --- Nou Hampshire --- Nou Mèxic --- Nova Jersey --- Nova York (Estat) --- Oest (Estats Units d'Amèrica) --- Ohio --- Oklahoma --- Oregon --- Pennsilvània --- Rhode Island --- Tennessee --- Texas --- Utah --- Vermont --- Virgínia --- Virgínia de l'Oest --- Washington (Districte de Colúmbia) --- Washington (Estat) --- Wisconsin --- Wyoming --- Yellowstone National Park --- Amerikanʹ Veĭtʹsėndi͡avks Shtattnė --- É.-U. --- ÉU --- Spojené obce severoamerické --- Est (Estats Units d'Amèrica) --- Drug abuse. --- Clinical Medicine.