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The book Heat Shock Protein 60 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP60 in human diseases and disorders. Using an integrative approach, the contributors provide a synopsis of novel mechanisms and signal transduction pathways. To enhance the ease of reading and comprehension the book has further been subdivided into various section including; Section I: Biomolecular Aspects of HSP60; Section II: HSP60 and Cancer; Section III: HSP60 and Inflammatory Diseases and Disorders; Section IV: HSP60 and Cardiovascular Diseases and Disorders; Section V: HSP60 and Neurological and Neurosciences; Section VI: Biomolecular Aspects of HSP60; Section VII: HSP60 and Skeletal Muscle Diseases and Disorders; and Section VIII: HSP60 in Human Health. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Neurology & Neuroscience, Oncology, Cardiovascular Disease, Skeletal Muscle Diseases and Disorders, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Heat shock proteins. --- Stress proteins --- Proteins --- Proteins . --- Protein Science. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Proteïnes --- Biomolècules --- Albúmines --- Apoproteïnes --- Conformació de proteïnes --- Enzims --- Factors de transcripció --- Glicoproteïnes --- Lipoproteïnes --- Nucleoproteïnes --- Pèptids --- Prions --- Protamines --- Proteïnes citosquelètiques --- Proteïnes de membrana --- Proteïnes de la sang --- Proteïnes recombinants --- Proteïnes supressores de tumors --- Receptors cel·lulars --- Ubiqüitina --- Xaperones moleculars --- Proteòmica
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The Protein Reviews series serves as a publication vehicle for reviews that focus on crucial contemporary and vital aspects of protein structure, function, evolution and genetics. Volumes are published online first, prior to publication in a printed book. Chapters are selected according to their importance to the understanding of biological systems, relevance to the unravelling of issues associated with health and disease, or impact on scientific or technological advances and developments. Volume 21 presents eight review chapters authored by experts in the related fields. The first chapter covers the enzyme squalene monooxygenase and lipid levels and its relevance in health and disease. Chapter two presents a systematic analysis of the structural and functional aspects of heteromeric solute carriers. The third chapter provides a review of the role of CI- in type IV collagen assembly, function, and disease, including future directions for studies. This is followed by a summary in chapter four about the recent progress on defining the roles of the Slit-Robo signaling in bone metabolism and the possible roles of the interaction between Robo and neural epidermal growth factor-like proteins. Chapter five discusses recent data about the evolutionary aspects on structural differences between humans and the nematode in relation to previous knowledge of core proteins and GAG-attachment sites in Chn and CS proteoglycans of C.elegans and humans. The sixth chapter summarizes the immunochemical character of the IGHV1-69-derived RFs and the recognition mechanism of the IGHV1-69-derived RFs. Chapter seven covers regulated alternative translocation and its role as an emerging mechanism to regulate transmembrane proteins. Finally, chapter eight reviews current progress on IL-36 protein and biology and novel investigative tools. This volume is intended for research scientists, clinicians, physicians and graduate students in the fields of biochemistry, cell biology, molecular biology, immunology and genetics. .
Proteins . --- Protein Structure. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Proteins. --- Proteïnes --- Biomolècules --- Albúmines --- Apoproteïnes --- Conformació de proteïnes --- Enzims --- Factors de transcripció --- Glicoproteïnes --- Lipoproteïnes --- Nucleoproteïnes --- Pèptids --- Prions --- Protamines --- Proteïnes citosquelètiques --- Proteïnes de membrana --- Proteïnes de la sang --- Proteïnes recombinants --- Proteïnes supressores de tumors --- Receptors cel·lulars --- Ubiqüitina --- Xaperones moleculars --- Proteòmica
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Protein folding --- RNA --- Biomolecules --- Protein Engineering. --- Protein Folding. --- Proteins --- Protéines --- ARN --- Biomolécules --- Conformation --- Design --- analysis. --- Repliement --- Protein Folding, Globular --- Folding, Globular Protein --- Folding, Protein --- Foldings, Globular Protein --- Foldings, Protein --- Globular Protein Folding --- Globular Protein Foldings --- Protein Foldings --- Protein Foldings, Globular --- Genetic Engineering, Protein --- Proteins, Genetic Engineering --- Genetic Engineering of Proteins --- Engineering, Protein --- Engineering, Protein Genetic --- Protein Genetic Engineering --- Biological molecules --- Ribonucleic acid --- Ribose nucleic acid --- Folding of proteins --- Folding --- Protein Engineering --- Protein Folding --- analysis --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Molecular Mechanisms of Pharmacological Action --- Proteostasis --- Protein Multimerization --- Intrinsically Disordered Proteins --- Genetic Engineering --- Directed Molecular Evolution --- DNA Shuffling --- Molecular Farming --- Molecules --- Molecular biology --- Nucleic acids --- Ribose --- Protéines --- Biomolécules --- Protein folding. --- Protein --- Protein engineering. --- Technologie des protéines. --- Protein design --- Biochemical engineering --- Genetic engineering --- Conformació de proteïnes. --- Enginyeria de proteïnes. --- Revistes electròniques. --- Enginyeria de proteïnes --- Proteïnes --- Biomolècules --- Anàlisi --- Disseny --- Conformació
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The book Heat Shock Proteins in Neuroscience provides the most comprehensive review on contemporary knowledge on the role of HSP in signaling pathways relevant to a number of diseases. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding of Neurological Aspects of HSP; Section II, focuses on Aspects of HSP in Neurodegenerative Diseases and Disorders, Section III, emphasizes the importance of HSP in Multiple Sclerosis; Section IV, reviews critical Aspects of HSP in Alzheimer’s Disease and Section V, gives a comprehensive update of the Development of HSP-Based Therapies for Neurological Disorders. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for starters and professionals in the fields of Neurology and Neurosciences, Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Heat shock proteins. --- Stress proteins --- Proteins --- Proteins . --- Protein Science. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Proteïnes --- Neurociències --- Neurociència --- Ciències neurològiques --- Ciències de la salut --- Neuroanatomia --- Neurobiologia --- Neurociència computacional --- Neuroendocrinologia --- Neurofarmacologia --- Neurogenètica --- Neuroquímica --- Sistema nerviós --- Biomolècules --- Albúmines --- Apoproteïnes --- Conformació de proteïnes --- Enzims --- Factors de transcripció --- Glicoproteïnes --- Lipoproteïnes --- Nucleoproteïnes --- Pèptids --- Prions --- Protamines --- Proteïnes citosquelètiques --- Proteïnes de membrana --- Proteïnes de la sang --- Proteïnes recombinants --- Proteïnes supressores de tumors --- Receptors cel·lulars --- Ubiqüitina --- Xaperones moleculars --- Proteòmica
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This volume explores experimental strategies to study progranulin as a regulatory protein in biological and disease processes. The chapters in this book are divided into four parts: Part One is an introduction to the topic; Part Two looks at analytical and in vitro methods to study progranulin biology; Part Three discusses the role of progranulin in cancer; and Part Four describes the process of using animal models to study progranulin in health and disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Progranulin: Methods and Protocols is a valuable resource for experienced researchers who want to expand their studies of this field, and newcomers who want to begin including progranulin into their work.”.
Biochemistry. --- Protein Science. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition --- Cromosomes humans --- Proteïnes --- Manuals de laboratori --- Tècniques de laboratori --- Biomolècules --- Albúmines --- Apoproteïnes --- Conformació de proteïnes --- Enzims --- Factors de transcripció --- Glicoproteïnes --- Lipoproteïnes --- Nucleoproteïnes --- Pèptids --- Prions --- Protamines --- Proteïnes citosquelètiques --- Proteïnes de membrana --- Proteïnes de la sang --- Proteïnes recombinants --- Proteïnes supressores de tumors --- Receptors cel·lulars --- Ubiqüitina --- Xaperones moleculars --- Proteòmica --- Cromosomes --- Genètica humana --- Genoma humà --- Cromosoma 15 humà
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This volume provides a wide range of methods and protocols detailing various protein structures as platforms for building architectures with targeted application. Chapters guide the readers through exploiting a number of protein scaffolds including virus nanoparticles, elastin and collagen peptides and proteins, and other protein templates for either building materials or presentation of ligands. Site-specific bioconjugation methods, some unique protein architectures, and techniques that exploit peptide amphiphile micelles and assembly of chaperones are also featured. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Protein Scaffolds: Design, Synthesis, and Applications aims to ensure successful results in the study of this vital field.
Biochemistry. --- Protein Science. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition --- Proteïnes --- Estructura molecular --- Manuals de laboratori --- Tècniques de laboratori --- Estructura química --- Molècules --- Orbitals moleculars --- Estructura atòmica --- Biomolècules --- Albúmines --- Apoproteïnes --- Conformació de proteïnes --- Enzims --- Factors de transcripció --- Glicoproteïnes --- Lipoproteïnes --- Nucleoproteïnes --- Pèptids --- Prions --- Protamines --- Proteïnes citosquelètiques --- Proteïnes de membrana --- Proteïnes de la sang --- Proteïnes recombinants --- Proteïnes supressores de tumors --- Receptors cel·lulars --- Ubiqüitina --- Xaperones moleculars --- Proteòmica
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This volume explores experimental and computational approaches to measuring the most widely studied protein assemblies, including condensed liquid phases, aggregates, and crystals. The chapters in this book are organized into three parts: Part One looks at the techniques used to measure protein-protein interactions and equilibrium protein phases in dilute and concentrated protein solutions; Part Two describes methods to measure kinetics of aggregation and to characterize the assembled state; and Part Three details several different computational approaches that are currently used to help researchers understand protein self-assembly. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Protein Self-Assembly: Methods and Protocols is a valuable resource for researchers who are interested in learning more about this developing field. .
Biochemistry. --- Protein Science. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition --- Proteïnes --- Estructura molecular --- Manuals de laboratori --- Tècniques de laboratori --- Estructura química --- Molècules --- Orbitals moleculars --- Estructura atòmica --- Biomolècules --- Albúmines --- Apoproteïnes --- Conformació de proteïnes --- Enzims --- Factors de transcripció --- Glicoproteïnes --- Lipoproteïnes --- Nucleoproteïnes --- Pèptids --- Prions --- Protamines --- Proteïnes citosquelètiques --- Proteïnes de membrana --- Proteïnes de la sang --- Proteïnes recombinants --- Proteïnes supressores de tumors --- Receptors cel·lulars --- Ubiqüitina --- Xaperones moleculars --- Proteòmica
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This book focuses on respiratory proteins, the broad hemoglobin family, as well as the molluscan and arachnid hemocyanins (and their multifunctional roles). Featuring 20 chapters addressing invertebrate and vertebrate respiratory proteins, lipoproteins and other body fluid proteins, and drawing on the editors’ extensive research in the field, it is a valuable addition to the Subcellular Biochemistry book series. The book covers a wide range of topics, including lipoprotein structure and lipid transport; diverse annelid, crustacean and insect defense proteins; and insect and vertebrate immune complexes. It also discusses a number of other proteins, such as the hemerythrins; serum albumin; serum amyloid A; von Willebrand factor and its interaction with factor VIII; and C-reactive protein. Given its scope, the book appeals to biologists, biomedical scientists and clinicians, as well as advanced undergraduates and postgraduates in these disciplines. Available as a printed book and also as an e-book and e-chapters, the fascinating material included is easily accessible.
Proteins . --- Biochemistry. --- Protein Science. --- Biochemistry, general. --- Proteins --- Vertebrates. --- Body fluids. --- Lipoproteins. --- Invertebrates. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Composition --- Invertebrata --- Animals --- Lipids --- Animal fluids and humors --- Body humors --- Fluids, Body --- Fluids and humors, Animal --- Humors, Body --- Vertebrata --- Chordata --- Proteïnes --- Oxigen en l'organisme --- Composició del cos humà --- Oximetria --- Anoxèmia --- Biomolècules --- Albúmines --- Apoproteïnes --- Conformació de proteïnes --- Enzims --- Factors de transcripció --- Glicoproteïnes --- Lipoproteïnes --- Nucleoproteïnes --- Pèptids --- Prions --- Protamines --- Proteïnes citosquelètiques --- Proteïnes de membrana --- Proteïnes de la sang --- Proteïnes recombinants --- Proteïnes supressores de tumors --- Receptors cel·lulars --- Ubiqüitina --- Xaperones moleculars --- Proteòmica
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Myosins are molecular motors that use the energy from ATP hydrolysis to move and exert tension on actin filaments. Although the best-known myosin is myosin II, which powers skeletal muscle contraction, there are at least two dozen classes of myosins, and cells generally express multiple isoforms. Myosins are involved in multiple cellular activities including cell structure, cell migration, intracellular trafficking, and cell-cell contact. Importantly, loss of function and mutation are associated with diseases including myopathies, hearing impairment, glomerulosclerosis, and cancer. Written by international experts in myosin motors and the approaches used to study them, this book is expected to provide a comprehensive assessment of the current status of our understanding of the structure and molecular mechanism of myosins and their cellular roles.
Myosin. --- Microfilament proteins --- Muscle proteins --- Molecular biology. --- Proteins . --- Cell biology. --- Molecular Medicine. --- Protein Science. --- Cell Biology. --- Protein Structure. --- Cell biology --- Cellular biology --- Biology --- Cells --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Systems biology --- Proteïnes --- Estructura molecular --- Citologia --- Biologia cel·lular --- Biologia --- Citogenètica --- Citoquímica --- Migració cel·lular --- Cèl·lules --- Cèl·lules animals --- Ultraestructura (Biologia) --- Estructura química --- Molècules --- Orbitals moleculars --- Estructura atòmica --- Biomolècules --- Albúmines --- Apoproteïnes --- Conformació de proteïnes --- Enzims --- Factors de transcripció --- Glicoproteïnes --- Lipoproteïnes --- Nucleoproteïnes --- Pèptids --- Prions --- Protamines --- Proteïnes citosquelètiques --- Proteïnes de membrana --- Proteïnes de la sang --- Proteïnes recombinants --- Proteïnes supressores de tumors --- Receptors cel·lulars --- Ubiqüitina --- Xaperones moleculars --- Proteòmica
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Nrf2, a transcription factor that mediates transcriptional responses to oxidative and xenobiotic stresses, plays a central role in cellular protection against internal or external toxins. Defects in Nrf2 and the relevant regulatory pathways are associated with a number of pathologies including inflammation,respiratory diseases, cardiovascular dysfunctions, metabolic syndrome and diabetes, neurodegeneration, and cancer. This book comprehensively reviews the up-to-date discoveries for the roles of Nrf2 in several human diseases in the context of inflammation. In particular, the molecular mechanisms that mediate the functions of Nrf2 and its interacting network in inflammation and pathogenesis are explicated. In addition, the research and therapeutic applications of Nrf2-targeting compounds in different diseases were summarized. This book is expected to be a valuable reference for worldwide researchers conducting both mechanistic and therapeutic studies of Nrf2 and relevant factors.
Transcription factors. --- Genetic transcription factors --- Proteins --- Immunology. --- Cell physiology. --- Gene expression. --- Oxidative stress. --- Cell Physiology. --- Gene Expression. --- Oxidative Stress. --- Oxidation-reduction reaction --- Stress (Physiology) --- Genes --- Genetic regulation --- Cell function --- Cytology --- Physiology --- Immunobiology --- Life sciences --- Serology --- Expression --- Expressió gènica --- Proteïnes --- Immunitat cel·lular --- Expressió dels gens --- Expressió genètica --- Expressivitat genètica --- Expressivitat gènica --- Ressenya genètica --- Regulació genètica --- Vectors genètics --- Immunologia cel·lular --- Immunitat --- Resposta immunitària --- Citocines --- Immunologia de la trasplantació --- Biomolècules --- Albúmines --- Apoproteïnes --- Conformació de proteïnes --- Enzims --- Factors de transcripció --- Glicoproteïnes --- Lipoproteïnes --- Nucleoproteïnes --- Pèptids --- Prions --- Protamines --- Proteïnes citosquelètiques --- Proteïnes de membrana --- Proteïnes de la sang --- Proteïnes recombinants --- Proteïnes supressores de tumors --- Receptors cel·lulars --- Ubiqüitina --- Xaperones moleculars --- Proteòmica
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