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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

quantitative physiology --- multiscale model --- computational model --- physiome --- systems biology --- complexity

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Science: general issues --- Physiology --- quantitative physiology --- multiscale model --- computational model --- physiome --- systems biology --- complexity

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Science: general issues --- Neurosciences --- computational model --- animal --- decision making --- motor control

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The free energy principle is a mathematical theory of the behaviour of self-organising systems that originally gained prominence as a unified model of the brain. Since then, the theory has been applied to a plethora of biological phenomena, extending from single-celled and multicellular organisms through to niche construction and human culture, and even the emergence of life itself. The free energy principle tells us that perception and action operate synergistically to minimize an organism’s exposure to surprising biological states, which are more likely to lead to decay. A key corollary of this hypothesis is active inference—the idea that all behavior involves the selective sampling of sensory data so that we experience what we expect to (in order to avoid surprises). Simply put, we act upon the world to fulfill our expectations. It is now widely recognized that the implications of the free energy principle for our understanding of the human mind and behavior are far-reaching and profound. To date, however, its capacity to extend beyond our brain—to more generally explain living and other complex adaptive systems—has only just begun to be explored. The aim of this collection is to showcase the breadth of the free energy principle as a unified theory of complex adaptive systems—conscious, social, living, or not.

Information technology industries --- Computer science --- message passing --- metabolism --- Bayesian --- stochastic --- non-equilibrium --- master equations --- cancer niches --- free energy --- Kikuchi approximations --- apoptosis --- metastasis --- cluster variation method --- Free Energy Principle --- active inference --- Bayesian brain --- generative models --- cybernetics --- embodiment --- enactivism --- cognitivism --- representations --- consciousness --- free will --- mental causation --- cognitive-affective development --- emotions --- feelings --- readiness potentials --- intentionality --- agency --- intelligence --- collective intelligence --- free energy principle --- agent-based model --- complex adaptive systems --- multiscale systems --- computational model --- uncertainty --- POMDP --- emotion --- affect control theory --- sociology --- permutation entropy --- disorder --- stress --- allostatic (hub) overload --- cascading failure --- disease --- hierarchical control systems --- critical slowing down --- model-based control --- adaptive robots --- generative model --- Bayesian inference --- filtering --- neurotechnology --- n/a

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The free energy principle is a mathematical theory of the behaviour of self-organising systems that originally gained prominence as a unified model of the brain. Since then, the theory has been applied to a plethora of biological phenomena, extending from single-celled and multicellular organisms through to niche construction and human culture, and even the emergence of life itself. The free energy principle tells us that perception and action operate synergistically to minimize an organism’s exposure to surprising biological states, which are more likely to lead to decay. A key corollary of this hypothesis is active inference—the idea that all behavior involves the selective sampling of sensory data so that we experience what we expect to (in order to avoid surprises). Simply put, we act upon the world to fulfill our expectations. It is now widely recognized that the implications of the free energy principle for our understanding of the human mind and behavior are far-reaching and profound. To date, however, its capacity to extend beyond our brain—to more generally explain living and other complex adaptive systems—has only just begun to be explored. The aim of this collection is to showcase the breadth of the free energy principle as a unified theory of complex adaptive systems—conscious, social, living, or not.

message passing --- metabolism --- Bayesian --- stochastic --- non-equilibrium --- master equations --- cancer niches --- free energy --- Kikuchi approximations --- apoptosis --- metastasis --- cluster variation method --- Free Energy Principle --- active inference --- Bayesian brain --- generative models --- cybernetics --- embodiment --- enactivism --- cognitivism --- representations --- consciousness --- free will --- mental causation --- cognitive-affective development --- emotions --- feelings --- readiness potentials --- intentionality --- agency --- intelligence --- collective intelligence --- free energy principle --- agent-based model --- complex adaptive systems --- multiscale systems --- computational model --- uncertainty --- POMDP --- emotion --- affect control theory --- sociology --- permutation entropy --- disorder --- stress --- allostatic (hub) overload --- cascading failure --- disease --- hierarchical control systems --- critical slowing down --- model-based control --- adaptive robots --- generative model --- Bayesian inference --- filtering --- neurotechnology --- n/a