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The peppermint Initiative was created to overcome the lack of standardization in exhaled breath analysis. It is an inter-analytical platforms-benchmarking study, which was carried out in the OBiAChem laboratory. Concretely, in each analytical platform, the defined peppermint protocol was repeated on the exhaled breath of at least 10 subjects to monitor specific metabolites of the peppermint oil in the exhaled breath. With the resulting data, a statistical analysis will be carried out and should represent the variability range between laboratories and different types of instrumentation. Concerning the OBiAChem laboratory, the exhaled breath was sampled in Tedlar® bags and the target VOCs were analyzed by a TD-GC×GC-HRTOFMS. A previous optimization step on the exhaled breath sampling method was done and this determined the suitable sampling bags for the exhaled breath analysis, 1L Tedlar® bags. The data analysis highlighted that almost all of the monitored metabolites of peppermint oil gave reproducible results leading to the conclusion that the exhaled breath sampling method which was used is a reproducible method.

Separation sciences --- Analytical chemistry --- Comprehensive two-dimensional gas chromatography --- High resolution time of flight mass spectrometer --- Thermal desorption --- Exhaled breath sampling --- Sampling bag technology --- Inter-analytical platform study --- Peppermint Initiative --- Physique, chimie, mathématiques & sciences de la terre > Chimie

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Volatile organic compounds (VOCs) are a diverse group of carbon-based molecules that are volatile at ambient temperatures and are emitted by an organism as a result of metabolic processes of cells and associated microbiome. The qualitative and quantitative profile of VOCs in biological fluids can vary depending on the physiological changes. Therefore, the pattern of volatile metabolites may reflect the presence of several diseases. This has been intensively investigated in the last few decades, resulting in an increasing number of studies focused on new volatile biomarker discovery.This reprint aimed to summarize the recent findings related to VOCs detected in various biological fluids such as breath, urine and feces for biomedical applications. The content covers various topics, including but not limited to biomedical/medical application of VOC analysis, biomarker discovery, and novel approaches for sampling and analyzing VOCs.

Research & information: general --- Chemistry --- liquid–liquid extraction --- volatile compounds --- urine --- method optimization --- GC-MS --- 1H-NMR --- iron deficiency anaemia --- iron supplementation --- volatile organic compounds (VOCs) --- intestinal metabolome --- gut microbiome --- CDH --- microbiome --- VOCs --- spiroergometry --- outcome --- exhaled breath --- eNose --- smoking --- asthma --- COPD --- NTD-GC-MS --- breath --- lung cancer --- biomarkers --- volatile organic compounds --- urine analysis --- comprehensive two-dimensional gas chromatography --- kidney diseases --- urinary biomarkers --- hepatocellular carcinoma --- diagnosis --- headspace analysis --- untargeted analysis --- breath analysis --- cancer biomarkers --- volatolomics --- whole grain --- rye --- comprehensive two-dimensional gas chromatography–mass spectrometry --- dietary fiber --- e-nose --- electronic nose --- breathing rhythm --- mechanical ventilation --- anesthesia --- supplemental oxygen --- oxygen toxicity --- lipid peroxidation --- volatile aldehydes --- pentanal --- hexanal --- classification models --- dairy cows --- fecal headspace --- Mycobacterium avium ssp. paratuberculosis (MAP) --- paratuberculosis --- random forest --- stable air --- volatile organic compound (VOC) --- biomarker --- MCC–IMS --- ventilator-induced lung injury --- metabolome --- feces --- neonates --- fermentation --- protein --- carbohydrate --- short chain fatty acid --- metabolites --- volatile organic compound --- acute gastritis --- antibiotic treatment --- treatment dynamics: microbiota --- mid-infrared spectroscopy --- short-chain fatty acid --- alpha-keto acid --- Helicobacter pylori --- MOX sensors --- low sensing chamber volume --- calibration transfer --- standard samples --- piecewise direct standardization --- correlation alignment --- breath sampling --- pattern recognition