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Effects of microbes on the immune system.
Authors: ---
ISBN: 0781710375 9780781710374 Year: 1999 Publisher: Philadelphia : Lippincott Williams & Wilkins,


Book
Control of innate and adaptive immune responses during infectious diseases
Author:
ISBN: 1461404835 9786613353085 1283353083 1461404843 Year: 2012 Publisher: New York : Springer,

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Abstract

The interface between host and pathogen cells involves a complex series of molecular mechanisms. On one side host cells recognize pathogen structures and initiate immune responses. On the other side, pathogens continually evolve immune escape strategies aiming at establishing chronic disease and transmission to a new host. The balance between those two forces can determine the fate of infectious diseases. Either uncontrolled pathogen replication or tissue damage due to unleashed pro-inflammatory responses can be detrimental to the host. Here we explore immune regulatory mechanisms that take place during some of the most relevant infectious diseases worldwide. We provide a wide spectrum view of the current understanding of how the immune system modulates ongoing responses to prevent host pathology, as well as some immune evasion strategies used by some of those microbes.

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