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This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental framework to study quantitative and dynamical aspects of autophagy in single cancer cells using live-cell imaging and quantitative fluorescence microscopy. This framework can provide new insights on function of autophagic response in cancer cells.

Materials Science. --- Biomaterials. --- Computational Biology/Bioinformatics. --- Cancer Research. --- Cell Biology. --- Biophysics and Biological Physics. --- Oncology. --- Bioinformatics. --- Cytology. --- Cancérologie --- Bio-informatique --- Cytologie --- Health & Biological Sciences --- Biomedical Engineering --- Apoptosis --- Cell determination --- Mathematical models. --- Cell commitment --- Cell fate determination --- Commitment (Cytology) --- Determination (Cytology) --- Materials science. --- Cancer research. --- Cell biology. --- Biophysics. --- Biological physics. --- Developmental cytology --- Transdetermination (Cytology) --- Cell death --- Biological and Medical Physics, Biophysics. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Tumors --- Bio-informatics --- Biological informatics --- Information science --- Computational biology --- Systems biology --- Biocompatible materials --- Biomaterials --- Medical materials --- Medicine --- Biomedical engineering --- Materials --- Biocompatibility --- Prosthesis --- Data processing --- Biological physics --- Medical sciences --- Physics --- Cancer research --- Bioartificial materials --- Hemocompatible materials --- Biomaterials (Biomedical materials)