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Book
Thrombin generation in different cohorts : evaluation of the haemostatic potential
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ISBN: 9175194902 Year: 2013 Publisher: Linköping, Sweden : Linköping University,

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Book
Fractions sanguines humaines hémostatiques et fibrinolytiques
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ISBN: 9782225386213 2225386218 Year: 1974 Publisher: Paris: Masson,

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Book
Role and significance of coagulation markers in understanding and treating acute coronary syndomes
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Year: 1998 Publisher: St. Louis Mosby

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Book
In vivo and in vitro behavior of clotting factors in blood and tissues
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Year: 1964 Publisher: New York (N.Y.) : New York academy of sciences,

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Book
La place des facteurs de la coagulation recombinants dans la prise en charge de l'hémophilie A
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Year: 2016 Publisher: Bruxelles: UCL. Faculté de pharmacie et des sciences biomédicales,

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Hemophilia A is a rare, hereditary X-linked disease which result in deficiency of coagulation factor VIII. The treatment of this disease previously consisted of a transfusion of blood or fresh plasma, which was followed by the use of cryoprecipitate. The use of clotting factor VIII concentrates derived from plasma was associated with the transmission of infectious viruses (HIV, HCV) and the development of inhibitors. The recombinant factors are molecules derived from biotechnology and are very highly purified. This will prevent any infectious complications. When rFVIII are used in prophylaxis, they can not only prevent bleeding, but also to avoid long-term complications, such as hemophilic arthropathy. What would be the place of these rFVIII in practice ? Recent molecules like simoctocog alfa (Nuwiq ®) alfa turoctocog (Novoeight®) and octocog alfa (Kovaltry®) will be detailed, particularly their production and their effectiveness in the treatment of bleeding in hemophilia patients. L'hémophilie A est une maladie rare, héréditaire, liée au chromosome X qui se traduit par un déficit en facteur de coagulation VIII. Le traitement de cette maladie consistait auparavant en une transfusion de sang ou de plasma frais, qui a été suivie de l'utilisation des cryoprécipités. L'usage des concentrés de facteur de coagulation VIII dérivés du plasma a été associé à la transmission de virus infectieux (HIV, HVC) et le développement des inhibiteurs. Les facteurs recombinants sont des molécules issues de la biotechnologie et qui sont très hautement purifiées. Cela permet d'éviter d'éventuelles complications infectieuses. Lorsque les rFVIII sont utilisés en prophylaxie, ils permettent non seulement de prévenir les saignements, mais également,d'éviter les complications à long terme, comme par exemple l'arthropathie hémophilique.Quelle serait la place de ces rFVIII dans la pratique? Les molécules récentes comme le simoctocog alfa (Nuwiq®), le turoctocog alfa (Novoeight®) et l'octocog alfa (Kovaltry®) seront détaillées, en particulier leur production ainsi que leur efficacité dans la prise en charge des hémorragies chez les patients hémophiles.


Book
Human blood coagulation factor IX.
Authors: ---
ISBN: 9519910360 Year: 1977 Publisher: Helsinki s.n.

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Book
Evaluation of clotting factor consumption and its determinants in a population of adult haemophilia patients from Belgium

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Book
Individualisation du dosage en facteur VIII de coagulation dans l'hémophilie A
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Year: 2018 Publisher: Bruxelles: UCL. Faculté de pharmacie et des sciences biomédicales,

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Dissertation
On the structure and function of human factor VIII-von Willebrand factor : the effect of proteases
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Year: 1981 Publisher: Amsterdam Rodopi

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Inhibitors to coagulation factors
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ISBN: 0306451964 1461380014 1461303311 Year: 1995 Volume: 386 Publisher: New York, NY : Plenum Press,

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