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CLOZAPINE

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

psychosis --- antipsychotic --- clozapine --- schizophrenia --- treatment refractory

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Clozapine --- Antipsychotic Agents --- Schizophrenia --- analogs & derivatives --- chemical synthesis --- drug therapy

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Clozapine --- Tranquilizing agents, major --- Receptors, endogenous substances --- Azepines --- Chemical synthesis --- Analogs and derivatives --- Chemistry --- Pharmacology

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Spontaneously stereotyping female and male bank voles were injected daily (except on days assigned for monitoring behaviour) during 3 weeks with placebo, the neurolepticum clozapine or the SSRI antidepressant citalopram. Clozapine blocks dopamine (DA) receptors and acts as a partial serotonin (5-HT) antagonist, while citalopram is a specific 5-HT agonist. Stereotypies in both sexes were left unaffected by clozapine treatment, but citalopram markedly reduced stereotypy levels in females. Animal stereotypies have been widely used in models to provide insight into the underlying pathophysiological processes in human mental disturbances. The present findings highlight the importance of examining sex as a significant variable in evaluating responses to pharmacotherapy, and the demonstrated effect of citalopram indicates that stereotyping female bank voles may be useful in new animal models for human anxiety and mood disorders.

5-ht. --- 5-ht2c. --- Animal model. --- Animal-model. --- Animal-models. --- Animal. --- Antidepressant. --- Anxiety. --- Bank vole. --- Bank voles. --- Behavior. --- Behaviour. --- Citalopram. --- Clozapine. --- Compulsive. --- Disorder. --- Dopamine. --- Female. --- Females. --- Human. --- Knockout mouse. --- Knockout. --- Level. --- Male. --- Model. --- Models. --- Mood disorders. --- Mood. --- Mouse. --- Neuroleptica. --- Obsessive-compulsive disorder. --- Ocd. --- Pharmacotherapy. --- Placebo. --- Receptor. --- Receptors. --- Response. --- Responses. --- Serotonin. --- Sex. --- Sexes. --- Ssri. --- Stereotypies. --- Stereotypy. --- Treatment. --- Vole. --- Voles.