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The successful book of andrology now in a new edition! This book gives a complete, interdisciplinary overview of the central topics of andrology, infertility, hypogonadism, contraception and erectile dysfunction. It contains detailed information on the clinical practice of couple treatment, andrology-relevant gynecology and modern methods of assisted fertilization, psychological factors of infertility, endocrinology and reproductive functions of the aging man as well as on an important sub-area of andrology, the male contribution to contraception. In addition, the relevant scientific foundations (including molecular biology and genetics) are also covered. Completely revised and updated according to the latest scientific research, the new edition represents a reference for andrology, which no doctor who deals with the topic can miss. For andrologists, practitioners and residents, urologists, dermatologists and internists who deal with the area of andrology and male reproductive medicine.

Reproductive health. --- Urology. --- Endocrinology. --- Dermatology. --- Medical genetics. --- Reproductive Medicine. --- Clinical Genetics.

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This volume contains a comprehensive collection of laboratory protocols used by researchers to analyze varied aspects of non-alcoholic steatohepatitis (NASH). The chapters in this book cover topics such as methods for histological diagnosis of NASH; the purpose of generating an in vivo NASH model; protocols for isolating hepatocytes and Kupffer cells, bone marrow derived macrophages, and adipocytes; techniques to develop human pluripotent stem cells-derived liver organoids; single-cell and RNA-sequencing; and a description of how to extract exosomes and exosomal miRNAs from mesenchymal stem cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and practical, Non-Alcoholic Steatohepatitis: Methods and Protocols is a valuable resource for new and experiences investigators studying NASH, and serves as an essential reference on NASH for basic and clinical researchers and students. .

Medical genetics. --- Stem cells. --- Clinical Genetics. --- Stem Cell Biology. --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- Genetic aspects

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This book aims at providing an up-to-date report to cover key aspects of existing problems in the emerging field of targets in gene therapy. With the contributions in various disciplines of gene therapy, the book brings together major approaches: Target Strategy in Gene Therapy, Gene Therapy of Cancer and Gene Therapy of Other Diseases. This source enables clinicians and researchers to select and effectively utilize new translational approaches in gene therapy and analyze the developments in target strategy in gene therapy.

Medical genetics. --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- Genetic aspects --- Medical genetics

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Autoimmune disorders are known to affect a substantial number of people worldwide, demonstrating a gender bias and are the second largest cause of chronic illness. Recently, the attention has been focused on lifestyle changes as a major factor in the rise of autoimmune disease frequency. The two sections of this book are focused on the new opportunities for moving research forward, leading to a new approach to prevention and treatment of autoimmune diseases. A better understanding of the mechanisms of gene expression and triggering signaling pathways, which is involved in autoimmune pathogenesis simultaneously with current data for the interaction of microbiota with human immune system, will help to better understand the immune imbalance implicated in autoimmunity.

Medical genetics. --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- Genetic aspects --- Medical genetics

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Medical genetics --- Génétique médicale --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- Genetic aspects