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Poches infra-osseuses et technique de comblement à l'aide d'un hydroxylapatite poreux, l'interpore 200(R) : résultats cliniques après 1 an

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Abstract

L’obturation dentaire en or, amalgame ou composite est parfaitement tolérée.
L’obturation canalaire aux eugénates donne d’excellents résultats dans la guérison des lésions périapicales.
Le parodontes a toujours été le parent pauvre, en dentisterie, en matière de comblement et de régénération.
Il y a quelques temps encore, la fonte progressive du tissu de soutien des dents et l aperte des dents qui en découle étaient considérées comme un phénomène de dégénérescence normale qui accompagnait le vieillissement. Actuellement, on sait que les maladies parodontales sont des infections bactériennes, sensibles à l’action des antibiotiques, qu’elles peuvent être traitées d’une manière durable et même définitive si un détartrage minutieux des surfaces dentaires et radiculaires est effectué et s’il est suivi d’une surveillance attentive du développement de la plaque dentaire par le patient et le praticien.
La fonte osseuse horizontale, bien qu’étant irréversible, peut-être stabilisée par un traitement non chirurgical et la migration apicale de l’attache épithélio-conjonctive est stoppée. Les soins prodigués à des patients souffrant de parodontie chronique se veulent donc de moins en moins chirurgicaux.
Malheureusement, dans les cas de parodontie sévère, la lyse osseuse est plus irrégulière, créant ainsi des lésions à parois verticales, l’attache épithéliale migre plus apicalement que le niveau de la crête osseuse.
Il y a formation de poches infra-osseuses.
Ces lésions profondes demandent une attention particulière car elles sont souvent le siège d’inflammation chronique et le point de départ d’une récidive d’une maladie parodontale.
La chirurgie est parfois inévitable au niveau de tel site, elle devra se faire dans un esprit de respect des tissus parodontaux sains.
Non content de la guérison, certaines techniques nouvelles prônent la régénération des tissus lysés par un comblement naturel ou artificiel des lésions.
Plusieurs techniques de comblement au moyen de tissus osseux ou d’autres biomatériaux ont été tentées. Récemment ont paru des études montrant qu’il est possible en empêchant, après traitement, l’épithélium et le tissu conjonctif gingival de participer au processus de cicatrisation, d’obtenir la formation d’une nouvelle attache sur les surfaces radiculaires précédemment exposées à la plaque dentaire.
Le excellents résultats cliniques obtenus par certains auteurs, les images histologiques chez l’animal et chez l’homme, la facilité d’emploi et la disponibilité du produit nous fait choisir comme test de comblement un des derniers-nés dans la famille des biomatériaux céramiques poreux :l’Interpore 200®.
Dans la première partie du travail, l’exposerai la morphologie, la prévalence et les possibilités de traitement de la poche infra-osseuse. Un historique des techniques de comblement sera dressés, les résultats obtenus par les différents matériaux seront présentés et commentés. Je détaillerai brièvement la chimie des bio-matériaux avant de présenter l’Interpore 200®. Je terminerai en parlant de la guérison parodontale et de la réattache.
La deuxième partie traitera de notre expérimentation cliniques de l’Interpore 200®, un an de recul après la greffe


Book
Gestion des essais cliniques de phase I à la pharmacie d'un hôpital universitaire belge : comparaison multicentrique des pratiques en France et en Belgique
Authors: --- --- ---
Year: 2016 Publisher: Bruxelles: UCL. Faculté de pharmacie et des sciences biomédicales,

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Background: Phase I clinical trials (PICT) are the first stage a new drug is tested in humans. The effects of investigational medicinal products (IMP) in humans are therefore unknown. Hospital pharmacists have been involved in clinical trials for many years. The management of PICT by hospital pharmacists has not been described yet. Objective: The aim of the study was to analyze the management of PICT in a hospital pharmacy and to compare practices between 4 hospitals and 2 clinical research units (CRU) in France and Belgium in order to identify potential difficulties related to the management of PICT by pharmacists and to elaborate some recommendations. Methods: It was a descriptive observational study. First in a Belgian teaching hospital, we identified and characterized the management of PICT at the pharmacy. Data on PICT prescriptions with preparation were collected. Secondly, in 3 other hospital pharmacies and in 2 pharmacy services CRU we analyzed the management of PICT. A pharmacist of each pharmacy was interviewed. Results: In hospitals the majority of PICT is commercial studies conducted in oncology. At the first hospital we received 84 prescriptions for PICT with a preparation during the collect from 11 protocols. In the 2 clinical research units PICT involve healthy volunteers. In hospital pharmacies no major differences between the management of PICT and phases II and III clinical trials was observed except for the transport from pharmacy to patient. Some difficulties related to commercial bags were explained by interviewed pharmacists. Conclusions: This study highlights for the first time the management of PICT in hospital pharmacies. This is comparable to the management of phase II and III trials. Some difficulties were highlighted regarding preparations of PICT IMP: complexity, timing and non-exact volume with commercial bags. A planning with patients in PICT could be organized for pharmacies. The study could be repeated in other hospitals to confirm these results.


Dissertation
Contribution à l'étude de la chimiothérapie intrapéritonéale en cancérologie
Authors: ---
Year: 1996 Publisher: [S.l.]: [chez l'auteur],


Book
An introduction to statistics in early phase trials
Authors: --- ---
ISBN: 0470059850 9780470059852 Year: 2010 Publisher: Chichester: Wiley,

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Book
Early drug development : strategies and routes to first-in-human trials
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ISBN: 9780470170861 0470170867 Year: 2010 Publisher: Hoboken, N.J. : Wiley,

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Book
Phase I oncology drug development
Authors: --- ---
ISBN: 3030476820 3030476812 Year: 2020 Publisher: Cham, Switzerland : Springer,

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This book provides a detailed review of how oncology drug development has changed over the past decade, and serves as a comprehensive guide for the practicalities in setting up phase I trials. The book covers strategies to accelerate the development of novel antitumor compounds from the laboratory to clinical trials and beyond through the use of innovative mechanism-of-action pharmacodynamic biomarkers and pharmacokinetic studies. The reader will learn about all aspects of modern phase I trial designs, including the incorporation of precision medicine strategies, and approaches for rational patient allocation to novel anticancer therapies. Circulating biomarkers to assess mechanisms of response and resistance are changing the way we are assessing patient selection and are also covered in this book. The development of the different classes of antitumor agents are discussed, including chemotherapy, molecularly targeted agents, immunotherapies and also radiotherapy. The authors also discuss the lessons that the oncology field has learnt from the development of hematology-oncology drugs and how such strategies can be carried over into therapies for solid tumors. There is a dedicated chapter that covers the specialized statistical approaches necessary for phase I trial designs, including novel Bayesian strategies for dose escalation. This volume is designed to help clinicians better understand phase I clinical trials, but would also be of use to translational researchers (MDs and PhDs), and drug developers from academia and industry interested in cancer drug development. It could also be of use to phase I trial study coordinators, oncology nurses and advanced practice providers. Other health professionals interested in the treatment of cancer will also find this book of great value. .

Keywords

Oncology  . --- Radiotherapy. --- Oncology. --- Radiation therapy --- Electrotherapeutics --- Hospitals --- Medical electronics --- Medical radiology --- Therapeutics, Physiological --- Phototherapy --- Tumors --- Radiological services --- Antineoplastic agents --- Cancer --- Drug development. --- Design. --- Chemotherapy. --- Development of drugs --- Drugs --- New drug development --- Pharmacology --- Pharmacy --- Anticancer agents --- Antineoplastic drugs --- Antineoplastics --- Antitumor agents --- Antitumor drugs --- Cytotoxic drugs --- Inhibitors, Neoplasm --- Neoplasm inhibitors --- Development --- Treatment --- Chemotherapy --- Antineoplastic Agents. --- Drug Development. --- Neoplasms --- Clinical Trials, Phase I as Topic. --- drug therapy. --- Clinical Trials, Phase 1 --- Drug Evaluation, FDA Phase 1 --- Drug Evaluation, FDA Phase I as Topic --- Evaluation Studies, FDA Phase 1 --- Human Microdosing Trials --- Microdosing Trials, Human --- Phase 1 Clinical Trials --- Clinical Trials, Phase I --- Drug Evaluation, FDA Phase I --- Evaluation Studies, FDA Phase I --- Human Microdosing Trial --- Phase 1 Clinical Trial --- Phase I Clinical Trial --- Phase I Clinical Trials --- Microdosing Trial, Human --- Trial, Human Microdosing --- Trials, Human Microdosing --- Nontherapeutic Human Experimentation --- Medication Development --- Pharmaceutical Development --- Computational Prediction of Drug-Target Interactions --- Drug Target Prediction --- Development, Drug --- Development, Medication --- Development, Pharmaceutical --- Drug Target Predictions --- Prediction, Drug Target --- Target Prediction, Drug --- Anticancer Agents --- Antineoplastic Drugs --- Antitumor Agents --- Antitumor Drugs --- Cancer Chemotherapy Agents --- Cancer Chemotherapy Drugs --- Chemotherapeutic Anticancer Agents --- Chemotherapeutic Anticancer Drug --- Anticancer Agent --- Antineoplastic --- Antineoplastic Agent --- Antineoplastic Drug --- Antitumor Agent --- Antitumor Drug --- Cancer Chemotherapy Agent --- Cancer Chemotherapy Drug --- Agent, Anticancer --- Agent, Antineoplastic --- Agent, Antitumor --- Agent, Cancer Chemotherapy --- Agents, Anticancer --- Agents, Antineoplastic --- Agents, Antitumor --- Agents, Cancer Chemotherapy --- Agents, Chemotherapeutic Anticancer --- Chemotherapy Agent, Cancer --- Chemotherapy Agents, Cancer --- Chemotherapy Drug, Cancer --- Chemotherapy Drugs, Cancer --- Drug, Antineoplastic --- Drug, Antitumor --- Drug, Cancer Chemotherapy --- Drug, Chemotherapeutic Anticancer --- Drugs, Antineoplastic --- Drugs, Antitumor --- Drugs, Cancer Chemotherapy --- Cytotoxins --- Interferon Inducers --- Anticarcinogenic Agents


Book
Making medical decisions for the profoundly mentally disabled
Author:
ISBN: 0262269813 1423726030 9780262269810 9781423726036 Year: 2005 Publisher: Cambridge, Mass. MIT Press

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A legal and moral analysis of medical decision making on behalf of those with such severe cognitive impairments that they cannot exercise self-determination.In this book, Norman Cantor analyzes the legal and moral status of people with profound mental disabilities--those with extreme cognitive impairments that prevent their exercise of medical self-determination. He proposes a legal and moral framework for surrogate medical decision making on their behalf. The issues Cantor explores will be of interest to professionals in law, medicine, psychology, philosophy, and ethics, as well as to parents, guardians, and health care providers who face perplexing issues in the context of surrogate medical decision making.The profoundly mentally disabled are thought by some moral philosophers to lack the minimum cognitive ability for personhood. Countering this position, Cantor advances both theoretical and practical arguments for according them full legal and moral status. He also argues that the concept of intrinsic human dignity should have an integral role in shaping the bounds of surrogate decision making. Thus, he claims, while profoundly mentally disabled persons are not entitled to make their own medical decisions, respect for intrinsic human dignity dictates their right to have a conscientious surrogate make medical decisions on their behalf. Cantor discusses the criteria that bind such surrogates. He asserts, contrary to popular wisdom, that the best interests of the disabled person are not always the determinative standard: the interests of family or others can sometimes be considered. Surrogates may even, consistent with the intrinsic human dignity standard, sometimes authorize tissue donation or participation in nontherapeutic medical research by profoundly disabled persons. Intrinsic human dignity limits the occasions for such decisions and dictates close attention to the preferences and feelings of the profoundly disabled persons themselves. Cantor also analyzes the underlying philosophical rationale that makes these decision-making criteria consistent with law and morals.

Keywords

Conservatorships --- Informed consent (Medical law) --- Insanity (Law) --- Medical ethics --- Mental health laws --- Consentement éclairé (Droit médical) --- Droit à la mort --- Santé mentale --- Tutelle et curatelle --- Éthique médicale --- Mental Competency --- Mentally Disabled Persons --- Decision Making --- Informed Consent --- Legal Guardians --- Right to Die --- Behavior and Behavior Mechanisms --- Human Rights --- Psychological Phenomena and Processes --- Human Experimentation --- Social Control, Formal --- Jurisprudence --- Principle-Based Ethics --- Sterilization, Reproductive --- Freedom --- Disabled Persons --- Ethics --- Thinking --- Social Control, Informal --- Persons --- Health Services --- Named Groups --- Sociology --- Philosophy --- Humanities --- Psychiatry and Psychology --- Health Care Facilities, Manpower, and Services --- Biomedical Research --- Investigative Techniques --- Mental Processes --- Research --- Urogenital Surgical Procedures --- Health Care --- Health Care Economics and Organizations --- Science --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Social Sciences --- Surgical Procedures, Operative --- Anthropology, Education, Sociology and Social Phenomena --- Natural Science Disciplines --- Disciplines and Occupations --- Ethical Analysis --- Personal Autonomy --- Nontherapeutic Human Experimentation --- Personhood --- Tissue and Organ Procurement --- Third-Party Consent --- Coercion --- Patient Rights --- Sterilization, Involuntary --- Law - U.S. --- Law, Politics & Government --- Disabled Legislation - U.S. --- Decision making. --- Droit --- Prise de décision. --- legislation & jurisprudence --- ethics --- Decision making --- United States --- Libertarianism --- Liberty --- Freedoms --- Female Sterilization --- Female Sterilization, Voluntary --- Male Sterilization --- Male Sterilization, Voluntary --- Reproductive Sterilization --- Voluntary Sterilization --- Female Sterilizations --- Female Sterilizations, Voluntary --- Male Sterilizations --- Male Sterilizations, Voluntary --- Reproductive Sterilizations --- Sterilization, Female --- Sterilization, Male --- Sterilization, Voluntary --- Sterilizations, Female --- Sterilizations, Male --- Sterilizations, Reproductive --- Sterilizations, Voluntary --- Voluntary Female Sterilization --- Voluntary Female Sterilizations --- Voluntary Male Sterilization --- Voluntary Male Sterilizations --- Voluntary Sterilizations --- Principlism --- Ethic, Principle-Based --- Ethics, Principle-Based --- Principle Based Ethics --- Principle-Based Ethic --- Constitutional Law --- Court Decision --- Law --- Legal Aspects --- Legal Obligations --- Legal Status --- State Interest --- Litigation --- Medical Jurisprudence --- Aspect, Legal --- Aspects, Legal --- Constitutional Laws --- Court Decisions --- Decision, Court --- Decisions, Court --- Interest, State --- Interests, State --- Jurisprudence, Medical --- Law, Constitutional --- Laws --- Laws, Constitutional --- Legal Aspect --- Legal Obligation --- Litigations --- Obligation, Legal --- Obligations, Legal --- State Interests --- Status, Legal --- Regulation --- Social Control --- Control, Social --- Controls, Social --- Formal Social Control --- Formal Social Controls --- Regulations --- Social Controls --- Human Research Subject Protection --- Experimentation, Human --- Psychologic Processes and Principles --- Equal Rights --- Equal Right --- Human Right --- Right, Equal --- Right, Human --- Rights, Equal --- Rights, Human --- Conservators --- Law and mental illness --- Mental disability law --- Mental health --- Mental illness --- Mental illness and law --- Mentally ill --- People with mental disabilities --- Decision Making, Shared --- Decision Makings, Shared --- Making, Shared Decision --- Makings, Shared Decision --- Shared Decision Making --- Shared Decision Makings --- Death with Dignity --- Dignity, Death with --- Guardian, Legal --- Guardians, Legal --- Legal Guardian --- Consent, Informed --- Competence --- Incompetence, Mental --- Mental Competence --- Competency, Mental --- Incompetency, Mental --- Competence, Mental --- Mental Incompetence --- Mental Incompetency --- Mentally Retarded --- Mentally Disabled --- Mentally Handicapped --- Disabled, Mentally --- Mentally Disabled Person --- Person, Mentally Disabled --- Persons, Mentally Disabled --- Biomedical ethics --- Clinical ethics --- Ethics, Medical --- Health care ethics --- Medical care --- Medicine --- Compulsory Sterilization --- Forced Sterilization --- Involuntary Sterilization --- Compulsory Sterilizations --- Forced Sterilizations --- Involuntary Sterilizations --- Sterilization, Compulsory --- Sterilization, Forced --- Sterilizations, Compulsory --- Sterilizations, Forced --- Sterilizations, Involuntary --- Patient's Rights --- Patients' Rights --- Right to Treatment --- Patient Right --- Patient's Right --- Patients Rights --- Patients' Right --- Right to Treatments --- Right, Patient --- Right, Patient's --- Right, Patients' --- Rights, Patient --- Rights, Patient's --- Rights, Patients' --- Treatment, Right to --- Treatments, Right to --- Involuntary Fertility Control --- Fertility Control, Involuntary --- Donor Cards --- Organ Donation --- Required Organ Donation Request --- Required Request --- Tissue Donation --- Organ Procurement --- Organ Procurement Systems --- Tissue Procurement --- Card, Donor --- Cards, Donor --- Donor Card --- Organ Donations --- Organ Procurement System --- Organ Procurements --- Required Requests --- Tissue Donations --- Tissue Procurements --- Human Dignity --- Dignity, Human --- Nontherapeutic Research --- Research, Nontherapeutic --- Human Experimentation, Nontherapeutic --- Experimentation, Nontherapeutic Human --- Free Will --- Self Determination --- Autonomy, Personal --- Analysis, Ethical --- Analyses, Ethical --- Ethical Analyses --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Ghost Surgery --- Operative Procedures --- Operative Surgical Procedure --- Operative Surgical Procedures --- Procedure, Operative Surgical --- Procedures, Operative Surgical --- Surgery, Ghost --- Surgical Procedure, Operative --- Operative Procedure --- Procedure, Operative --- Procedures, Operative --- Science, Social --- Sciences, Social --- Social Science --- Sciences --- Healthcare Economics and Organizations --- Healthcare Facilities, Manpower, and Services --- Community-Based Distribution --- Contraceptive Distribution --- Delivery of Healthcare --- Dental Care Delivery --- Distribution, Non-Clinical --- Distribution, Nonclinical --- Distributional Activities --- Healthcare --- Healthcare Delivery --- Healthcare Systems --- Non-Clinical Distribution --- Nonclinical Distribution --- Delivery of Dental Care --- Health Care Delivery --- Health Care Systems --- Activities, Distributional --- Activity, Distributional --- Care, Health --- Community Based Distribution --- Community-Based Distributions --- Contraceptive Distributions --- Deliveries, Healthcare --- Delivery, Dental Care --- Delivery, Health Care --- Delivery, Healthcare --- Distribution, Community-Based --- Distribution, Contraceptive --- Distribution, Non Clinical --- Distributional Activity --- Distributions, Community-Based --- Distributions, Contraceptive --- Distributions, Non-Clinical --- Distributions, Nonclinical --- Health Care System --- Healthcare Deliveries --- Healthcare System --- Non Clinical Distribution --- Non-Clinical Distributions --- Nonclinical Distributions --- System, Health Care --- System, Healthcare --- Systems, Health Care --- Systems, Healthcare --- Procedure, Urogenital Surgical --- Procedures, Urogenital Surgical --- Surgical Procedure, Urogenital --- Surgical Procedures, Urogenital --- Urogenital Surgical Procedure --- Laboratory Research --- Research Activities --- Research and Development --- Research Priorities --- Activities, Research --- Activity, Research --- Development and Research --- Priorities, Research --- Priority, Research --- Research Activity --- Research Priority --- Research, Laboratory --- Human Information Processing --- Information Processing, Human --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Experimental Medicine --- Investigational Medicine --- Investigative Medicine --- Research, Biomedical --- Research, Medical --- Medical Research --- Medicine, Experimental --- Medicine, Investigational --- Medicine, Investigative --- Philosophical Overview --- Hedonism --- Stoicism --- Overview, Philosophical --- Overviews, Philosophical --- Philosophical Overviews --- Philosophies --- General Social Development and Population --- Services, Health --- Health Service --- Service, Health --- Person --- Informal Social Control --- Control, Informal Social --- Controls, Informal Social --- Informal Social Controls --- Social Controls, Informal --- Critical Thinking --- Thinking Skills --- Thinking Skill --- Thinking, Critical --- Egoism --- Ethical Issues --- Metaethics --- Moral Policy --- Natural Law --- Situational Ethics --- Ethical Issue --- Ethics, Situational --- Issue, Ethical --- Issues, Ethical --- Law, Natural --- Laws, Natural --- Moral Policies --- Natural Laws --- Policies, Moral --- Policy, Moral --- Physically Disabled --- Handicapped --- People with Disabilities --- Persons with Disabilities --- Physically Challenged --- Physically Handicapped --- Disabilities, People with --- Disabilities, Persons with --- Disability, Persons with --- Disabled Person --- Disabled, Physically --- Handicapped, Physically --- People with Disability --- Person, Disabled --- Persons with Disability --- Persons, Disabled --- Law and legislation --- Legal status, laws, etc. --- Moral and ethical aspects --- Community Consent --- Third Party Consent --- Spousal Consent --- Community Consents --- Consent, Community --- Consent, Spousal --- Consent, Third Party --- Consent, Third-Party --- Consents, Community --- Population Control --- Ethical Theory --- Defamation --- Lawyers --- Public Policy --- Helsinki Declaration --- Bioethical Issues --- Ethics, Research --- Embryo Research --- Fetal Research --- Research Subjects --- Psychologic Processes --- Psychological Processes --- Phenomena, Psychological --- Processes, Psychologic --- Processes, Psychological --- Psychological Phenomenas --- Psychological Processe --- Social Justice --- Human Rights Abuses --- Guardian and ward --- Problem Solving --- Euthanasia --- Advance Directives --- Living Wills --- Treatment Refusal --- Disclosure --- Therapeutic Misconception --- Insanity Defense --- Comprehension --- Bioethics --- Professional ethics --- Nursing ethics --- Social medicine --- Patient Advocacy --- Truth Disclosure --- Behavior Control --- Mandatory Programs --- Informed Consent By Minors --- Proxy --- Tissue and Organ Harvesting --- Beginning of Human Life --- Human Characteristics --- Clinical Trials, Phase I as Topic --- Self Concept --- Professional Autonomy --- Paternalism --- General Surgery --- Animals, Laboratory --- Pharmacy Philosophy --- Pharmacy Philosophies --- Philosophies, Pharmacy --- Philosophy, Pharmacy --- Power (Psychology) --- Social Conformity --- Thought --- Thoughts --- Censorship, Research --- Rehabilitation Research --- Bedridden Persons --- Immobilization --- Sports for Persons with Disabilities --- Health Services for Persons with Disabilities --- Freedom of Religion --- Religious Freedom --- Right to Movement --- Freedom, Religious --- Freedoms, Religious --- Movement, Right to --- Movements, Right to --- Religion Freedom --- Religion Freedoms --- Religious Freedoms --- Right to Movements --- to Movement, Right --- to Movements, Right --- Collective Human Rights --- Linguistic Rights --- Right to Housing and Shelter --- Rights of Indigenous Peoples --- Human Rights, Collective --- Indigenous Peoples Rights --- Rights, Collective Human --- Rights, Linguistic --- Citizen Science --- Power, Psychological --- PHILOSOPHY/Ethics & Bioethics --- BIOMEDICAL SCIENCES/General

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