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This work aims to highlight the different treatments to improve mucociliary clearance in people with cystic fibrosis. It will address both symptomatic and basic treatments that are currently available or under clinical trials. Currently, symptomatic treatments can only bring improvement in the quality of life for patients and increase their life expectancy. Many studies are underway for several molecules and evolve in a positive way to hope that in a near future E the mucociliary clearance can easily be treated Ce travail a pour objectif de mettre en évidence les différents traitements permettant d’améliorer la clairance mucociliaire chez les personnes atteintes de la mucoviscidose. Il abordera, à la fois, les traitements symptomatiques et de fonds existants ou étant en cours d’essais clinique. A l’heure actuelle, les différentes possibilités de soins ne peuvent qu’apporter une amélioration de la qualité de vie des patients et augmenter leur espérance de vie. De nombreuses études sont en cours pour plusieurs molécules et évoluent de façon positive vers l’espoir qu’un jour la clairance mucociliaire puisse être facilement traitée

Mucociliary Clearance --- Cystic Fibrosis

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Human red blood cells are formed mainly in the bone marrow and are believed to have an average life span of approximately 120 days. However, is it true for all red blood cells? What are the changes associated with red cell maturation, adulthood and senescence? What are the determinants of red cell life span and clearance? What are the mechanisms in control of red cell mass in healthy humans and patients with various forms of anemia? What are the markers of circulating red cell senescence and in cells during storage and transfusion? Within the life span may properties of red cells change leading to age-mixed circulating cell populations. Although these cells appear to be genetically terminated by the time they are released into the blood stream, they undergo surprisingly versatile modifications depending on the life-style and health conditions of a “human host”. Numerous disorders are believed to be associated with facilitated ageing of red blood cells. “In vitro ageing” and damage of red blood cells during storage is yet one more important issue related to the risks and efficiency of blood transfusion. Many of the mechanisms behind such effects are far from being fully understood. In this context the Research Topic is set to include articles in the field of biochemical investigations, biophysical approaches, physiological and clinical studies related to red blood cell maturation and aging. This includes Original Research, Methods, Hypothesis and Theory, Reviews and Perspectives.

Erythropoiesis --- senescence --- neocytolysis --- blood storage --- Clearance --- Vesiculation --- erythrocyte

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Human red blood cells are formed mainly in the bone marrow and are believed to have an average life span of approximately 120 days. However, is it true for all red blood cells? What are the changes associated with red cell maturation, adulthood and senescence? What are the determinants of red cell life span and clearance? What are the mechanisms in control of red cell mass in healthy humans and patients with various forms of anemia? What are the markers of circulating red cell senescence and in cells during storage and transfusion? Within the life span may properties of red cells change leading to age-mixed circulating cell populations. Although these cells appear to be genetically terminated by the time they are released into the blood stream, they undergo surprisingly versatile modifications depending on the life-style and health conditions of a “human host”. Numerous disorders are believed to be associated with facilitated ageing of red blood cells. “In vitro ageing” and damage of red blood cells during storage is yet one more important issue related to the risks and efficiency of blood transfusion. Many of the mechanisms behind such effects are far from being fully understood. In this context the Research Topic is set to include articles in the field of biochemical investigations, biophysical approaches, physiological and clinical studies related to red blood cell maturation and aging. This includes Original Research, Methods, Hypothesis and Theory, Reviews and Perspectives.

Erythropoiesis --- senescence --- neocytolysis --- blood storage --- Clearance --- Vesiculation --- erythrocyte

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Reticulocytes --- Erythrocytes --- Erythropoiesis --- senescence --- Clearance --- Anaemia --- Membrane Physiology --- Rheology --- Microfluidics

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Home to eighty thousand people, Accra’s Old Fadama neighborhood is the largest illegal slum in Ghana. Though almost all its inhabitants are Ghanaian born, their status as illegal “squatters” means that they live a precarious existence, marginalized within Ghanaian society and denied many of the rights to which they are entitled as citizens. The case of Old Fadama is far from unique. Across Africa, more than half the population now lives in cities, and a lack of affordable housing means that growing numbers live in similar illegal slum communities, often in appalling conditions. Drawing on rich, ethnographic fieldwork, the book takes as its point of departure the narratives that emerge from the everyday lives and struggles of these people, using the perspective offered by Old Fadama as a means of identifying wider trends and dynamics across African slums.Central to Stacey’s argument is the idea that such slums possess their own structures of governance, grounded in processes of negotiation between slum residents and external actors. In the process, Stacey transforms our understanding not only of slums, but of governance itself, moving us beyond prevailing state-centric approaches to consider how even a society’s most marginal members can play a key role in shaping and contesting state power (provided by publisher)

Slums --- #SBIB:39A4 --- Slum clearance --- Housing --- Toegepaste antropologie --- Sociology of environment --- Political sociology --- Accra