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This book comprises a collection of chapters describing topics from traditional radiation cytogenetic analysis methods to the modern fluorescence based-analysis and high throughput automatic analysis methods. Cytogenetic analysis is important not only in order to understand radiation-induced DNA damage in cells, but it is also a standard biological method to estimate human radiation exposure in the radiation accidents. Therefore, we prepared a series of chapters not only covering biological aspects but also exploring radiation physics and radiation protection. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and equipment, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Radiation Cytogenetics: Methods and Protocols serves both novices working on their first experiments as well as experienced researchers searching for tried-and-true techniques to adapt for their own laboratory.

Human genetics. --- Cell culture. --- Human Genetics. --- Cell Culture. --- Cultures (Biology) --- Cytology --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Technique --- Citogenètica humana --- Bioquímica clínica --- Química clínica --- Citogenètica --- Genètica humana --- Anàlisis clíniques --- Diagnòstic bioquímic --- Diagnòstic químic --- Química mèdica --- Bioquímica --- Diagnòstic de laboratori --- Anàlisi d'orina --- Anàlisi de sang --- Enzimologia clínica --- Valors de referència (Medicina) --- Laboratoris clínics --- Bioquímica de les malalties --- Bioquímica mèdica --- Bioquímica patològica --- Patobioquímica --- Bioquímica clínica veterinària

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This textbook provides a concise introduction and useful overview of the field of human population genomics, making the highly technical and contemporary aspects more accessible to students and researchers from various fields. Over the past decade, there has been a deluge of genetic variation data from the entire genome of individuals from many populations. These data have allowed an unprecedented look at human history and how natural selection has impacted humans during this journey. Simultaneously, there have been increased efforts to determine how genetic variation affects complex traits in humans. Due to technological and methodological advances, progress has been made at determining the architecture of complex traits. Split in three parts, the book starts with the basics, followed by more advanced and current research. The first part provides an introduction to essential concepts in population genetics, which are relevant for any organism. The second part covers the genetics of complex traits in humans. The third part focuses on applying these techniques and concepts to genetic variation data to learn about demographic history and natural selection in humans. This new textbook aims to serve as a gateway to modern human population genetics research for those new to the field. It provides an indispensable resource for students, researchers and practitioners from disparate areas of expertise.

Genetics. --- Biomathematics. --- Bioinformatics. --- Genetics and Genomics. --- Genetics and Population Dynamics. --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Systems biology --- Mathematics --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Data processing --- Human population genetics. --- Genomics. --- Human genetics --- Population genetics --- Genome research --- Genomes --- Molecular genetics --- Research --- Xenética humana --- Genètica humana --- Antropologia física --- Biologia humana --- Genètica --- Herència humana --- Citogenètica humana --- Cromosomes humans --- Genètica de poblacions humanes --- Genètica mèdica --- Genètica molecular humana --- Psicologia genètica --- Genoma humà

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The world population is rapidly aging—it is estimated that by 1950, around 17% of the population will be elderly. In this context, aging involves several physiological, psychological and highly complex social processes that vary from one person to another. For a long time, medical care for older adults has focused on treating chronic, age-related diseases and their associated consequences. Recently, biomedical research brings a novel point of view to develop more effective interventions by targeting the aging process itself rather than separate conditions. There is a growing number of reports indicating that aging is driven by several interconnected mechanisms and biological components referred to as the molecular pillars of aging. Interfering with these mechanisms could help to treat, prevent, and understand the development of age-related diseases and associated syndromes. This book provides a clinical perspective and general update on biomedical and genetic research in aging, moving from an update in the molecular pillars of aging to a perspective of the most recent pharmacological, clinical, and diagnostic applications using genomic approaches and techniques. While this book focuses on the specifics of genetics and genomics, it also adopts a clinical perspective of geroscience, which seeks to understand the genetic, molecular and cellular mechanisms that make aging an important risk factor and, sometimes, a determining factor in the diseases and common chronic conditions of older people. Additionally, Clinical Genetics and Genomics of Aging is a significant contribution to support aging research, as it shows that collaboration across disciplines is relevant to progress in the field. As more and more people benefit from increased longevity, clinician and researchers will be empowered by this knowledge to contribute to the progress of aging research.

Human genetics. --- Human Genetics. --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Aging --- Genetic aspects. --- Gene Expression Regulation --- genetics --- Expression Regulation, Gene --- Regulation, Gene Action --- Regulation, Gene Expression --- Gene Action Regulation --- Regulation of Gene Expression --- RNAi Therapeutics --- Gene Regulatory Networks --- Envelliment --- Genètica humana --- Genòmica --- Genètica molecular --- Metagenòmica --- Nutrigenòmica --- Genomes --- Antropologia física --- Biologia humana --- Genètica --- Herència humana --- Citogenètica humana --- Cromosomes humans --- Genètica de poblacions humanes --- Genètica mèdica --- Genètica molecular humana --- Psicologia genètica --- Genoma humà --- Senectut --- Biologia del desenvolupament --- Persones de mitjana edat --- Persones grans --- Gerontologia --- Longevitat --- Envelliment cerebral --- Factors d'edat en les malalties

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Behavior genetics. --- Behavior genetic analysis --- Behavioral genetics --- Human behavior genetics --- Psychogenetics --- Genetics --- Psychology --- Desenvolupament de la personalitat --- Genetica humana --- Herència humana --- Herència i medi --- Genètica de la conducta --- Anàlisi genètic de la conducta --- Genètica del comportament --- Psicogenètica --- Genètica --- Psicologia --- Evolució de la conducta --- Cultura i herència --- Genètica i medi --- Medi i herència --- Herència (Biologia) --- Innatisme (Psicologia) --- Influència del medi ambient en l'home --- Herència en l'home --- Eugenèsia --- Genètica humana --- Degeneració --- Antropologia física --- Biologia humana --- Citogenètica humana --- Cromosomes humans --- Genètica de poblacions humanes --- Genètica mèdica --- Genètica molecular humana --- Psicologia genètica --- Genoma humà --- Desenvolupament del caràcter --- Formació del caràcter --- Personalitat --- Canvi (Psicologia) --- Desenvolupament moral --- Socialització

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"Encompasses all aspects of chromosome biology and the application of molecular cytogenetic techniques in all areas of biomedicine."

Cytogenetics --- Chromosomes --- Molecular Biology --- Molecular genetics --- Cytogénétique --- Génétique moléculaire --- Periodicals. --- Périodiques --- Cytogenetics. --- Chromosomes. --- Biochemical Phenomena. --- Molecular genetics. --- Chromosome theory --- Biochemical Concepts --- Biochemical Phenomenon --- Biochemical Process --- Phenomena, Biochemical --- Biochemical Processes --- Biochemical Concept --- Concept, Biochemical --- Concepts, Biochemical --- Phenomenon, Biochemical --- Process, Biochemical --- Processes, Biochemical --- Chromosome --- Cytogenetic --- chromosome biology --- medical genetics --- Genetics --- Molecular biology --- Cytology --- Cell nuclei --- Crossing over (Genetics) --- Cytotaxonomy --- Karyokinesis --- Linkage (Genetics) --- Cytogenetic Analysis --- Chromosome Disorders --- Sex Chromosome Disorders --- moleculaire biologie --- Citogenètica. --- Cromosomes. --- Genètica molecular. --- Biologia molecular. --- Biofísica molecular --- Bioquímica molecular --- Biofísica --- Bioquímica --- Histoquímica --- Biologia molecular vegetal --- Codi genètic --- Diagnòstic molecular --- Endocrinologia molecular --- Evolució molecular --- Farmacologia molecular --- Genètica molecular --- Glicòmica --- Metabolòmica --- Microbiologia molecular --- Neurobiologia molecular --- Patologia molecular --- Proteòmica --- Reconeixement molecular --- Biomolècules --- Biologia molecular --- Genètica --- Clonatge molecular --- Elements genètics mòbils --- Genètica bioquímica --- Genètica molecular humana --- Genètica molecular vegetal --- Genòmica --- Gens --- Regulació genètica --- Variació en el nombre de còpies --- Herència (Biologia) --- Nuclis cel·lulars --- Anomalies cromosòmiques --- Al·lelomorfisme --- Cariotips --- Cromatina --- Cromosomes humans --- Cromosomes sexuals --- Recombinació genètica --- Telòmer --- Translocació (Genètica) --- Genètica cel·lular --- Citologia --- Citogenètica humana --- Mapatge cromosòmic