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For over 50 years, clinicians have known that macrolide antibiotics have effects on inflammation and the immune system that are not related to their antimicrobial properties. These immunomodulatory properties, best described for treating inflammatory airway diseases, protect the lung and the host and improve clinical status. This book summarizes our current knowledge regarding proposed mechanisms for these properties, established clinical results, and what the future may hold with emphasis on novel clinical applications and the fascinating development of non-antimicrobial macrolides with preserved and enhanced immunomodulatory properties.
Inflammation. --- Cancer. --- Immune system. --- Cellular signal transduction. --- Immunology. --- Immunotherapy. --- Cancer Biology. --- Immune Cell Signalling. --- Chronic rhinosinusitis. --- Immune response --- Macrolide therapy. --- Nasal polyps. --- Neutrophils. --- Regulation.
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It is with great pleasure that we present to you this Special Issue of Medical Sciences. In this issue, we present a comprehensive and contemporary review of the medical comorbidities that contribute to chronic rhinosinusitis, and, conversely, how our interventions as otolaryngologists can impact those systemic conditions. Our understanding of chronic rhinosinusitis has evolved tremendously over the last two decades. As we have learned, chronic rhinosinusitis—a chronic inflammatory condition of the nasal cavity and paranasal sinuses—is often a local inflammatory response to a systemic or mucosal disorder. The underlying systemic medical conditions not only influence the presentation and diagnosis of chronic rhinosinusitis, but also modify the patients’ response to medical and surgical interventions. Chronic rhinosinusitis associated with cystic fibrosis, for example, is a disorder quite distinct from that associated with aspirin-exacerbated respiratory disease. A clear understanding of the nuances that distinguish these unique and challenging disorders is critical for the practicing otolaryngologist. Equally important, however, is a clear understanding of the powerful benefits that our interventions as otolaryngologists can have for our patients’ rhinologic and systemic health. Knowing that our rhinologic interventions might spare an asthma patient a trip to an emergency room or reduce lung infections in a cystic fibrosis patient makes this a very exciting time to be a rhinologist. We hope you enjoy this Special Issue of Medical Sciences.
n/a --- AERD --- pediatric --- adenoidectomy --- chronic rhino sinusitis --- cystic fibrosis --- biofilm --- nasal polyps --- aspirin exacerbated respiratory disease --- eosinophilia --- eosinophil --- adenoiditis --- nasal poly --- endoscopic sinus surgery --- aspirin desensitization --- central compartment atopic disease --- medial maxillectomy --- allergy --- diagnosis --- adenoids --- asthma --- allergic fungal rhinosinusitis --- nasal polyposis --- Samter’s Triad --- medical management --- sinus surgery --- chronic rhinosinusitis --- sinusitis --- allergic rhinitis --- rhinosinusitis --- polyposis --- hyposmia --- Samter's Triad
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This Book, entiled “Allergic Rhinosinusitis and Airway Diseases”, presents the concept of united airway disease interaction, which comprises chronic rhinosinusitis and other lower airway disorders such as asthma. This concept furthers a deeper comprehension on the pathophysiology and management of upper and lower airway diseases. In this Book, the published papers cover different interesting topics such as healthcare equality, advanced biomarkers, accurate diagnosis and treatment, occupational exposure-induced upper airway allergy and neoplastic disease mimicking chronic rhinosinusitis.
Medicine --- chronic rhinosinusitis --- B-cell lymphoproliferative disorder --- sinus --- nasal allergies --- tannery worker --- Kanpur --- asthma --- ovalbumin --- saffron --- salbutamol --- IL’s --- TNF-α --- allergic rhinitis --- bronchial asthma --- allergy --- Th17 cells --- IL-17 --- IL-33 --- microRNA --- miR --- airway mucosal inflammation --- united airway disease --- acute rhinosinusitis --- acute recurrent rhinosinusitis --- Mediterranean diet --- nutritional evaluation --- nutritional therapy --- olfactory dysfunction --- anosmia --- post-acute COVID-19 --- nitric oxide --- NO --- exhaled NO --- FENO --- nasal peak flow --- atopic status --- total IgE --- specific IgE --- childhood asthma --- immunoblot --- ImmunoCAP --- otolaryngology --- sinusitis --- ethnic groups --- patient-reported outcome measures --- quality of life --- social justice --- n/a --- IL's
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This Book, entiled “Allergic Rhinosinusitis and Airway Diseases”, presents the concept of united airway disease interaction, which comprises chronic rhinosinusitis and other lower airway disorders such as asthma. This concept furthers a deeper comprehension on the pathophysiology and management of upper and lower airway diseases. In this Book, the published papers cover different interesting topics such as healthcare equality, advanced biomarkers, accurate diagnosis and treatment, occupational exposure-induced upper airway allergy and neoplastic disease mimicking chronic rhinosinusitis.
chronic rhinosinusitis --- B-cell lymphoproliferative disorder --- sinus --- nasal allergies --- tannery worker --- Kanpur --- asthma --- ovalbumin --- saffron --- salbutamol --- IL’s --- TNF-α --- allergic rhinitis --- bronchial asthma --- allergy --- Th17 cells --- IL-17 --- IL-33 --- microRNA --- miR --- airway mucosal inflammation --- united airway disease --- acute rhinosinusitis --- acute recurrent rhinosinusitis --- Mediterranean diet --- nutritional evaluation --- nutritional therapy --- olfactory dysfunction --- anosmia --- post-acute COVID-19 --- nitric oxide --- NO --- exhaled NO --- FENO --- nasal peak flow --- atopic status --- total IgE --- specific IgE --- childhood asthma --- immunoblot --- ImmunoCAP --- otolaryngology --- sinusitis --- ethnic groups --- patient-reported outcome measures --- quality of life --- social justice --- n/a --- IL's
Choose an application
This Book, entiled “Allergic Rhinosinusitis and Airway Diseases”, presents the concept of united airway disease interaction, which comprises chronic rhinosinusitis and other lower airway disorders such as asthma. This concept furthers a deeper comprehension on the pathophysiology and management of upper and lower airway diseases. In this Book, the published papers cover different interesting topics such as healthcare equality, advanced biomarkers, accurate diagnosis and treatment, occupational exposure-induced upper airway allergy and neoplastic disease mimicking chronic rhinosinusitis.
Medicine --- chronic rhinosinusitis --- B-cell lymphoproliferative disorder --- sinus --- nasal allergies --- tannery worker --- Kanpur --- asthma --- ovalbumin --- saffron --- salbutamol --- IL's --- TNF-α --- allergic rhinitis --- bronchial asthma --- allergy --- Th17 cells --- IL-17 --- IL-33 --- microRNA --- miR --- airway mucosal inflammation --- united airway disease --- acute rhinosinusitis --- acute recurrent rhinosinusitis --- Mediterranean diet --- nutritional evaluation --- nutritional therapy --- olfactory dysfunction --- anosmia --- post-acute COVID-19 --- nitric oxide --- NO --- exhaled NO --- FENO --- nasal peak flow --- atopic status --- total IgE --- specific IgE --- childhood asthma --- immunoblot --- ImmunoCAP --- otolaryngology --- sinusitis --- ethnic groups --- patient-reported outcome measures --- quality of life --- social justice --- chronic rhinosinusitis --- B-cell lymphoproliferative disorder --- sinus --- nasal allergies --- tannery worker --- Kanpur --- asthma --- ovalbumin --- saffron --- salbutamol --- IL's --- TNF-α --- allergic rhinitis --- bronchial asthma --- allergy --- Th17 cells --- IL-17 --- IL-33 --- microRNA --- miR --- airway mucosal inflammation --- united airway disease --- acute rhinosinusitis --- acute recurrent rhinosinusitis --- Mediterranean diet --- nutritional evaluation --- nutritional therapy --- olfactory dysfunction --- anosmia --- post-acute COVID-19 --- nitric oxide --- NO --- exhaled NO --- FENO --- nasal peak flow --- atopic status --- total IgE --- specific IgE --- childhood asthma --- immunoblot --- ImmunoCAP --- otolaryngology --- sinusitis --- ethnic groups --- patient-reported outcome measures --- quality of life --- social justice
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