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Chromosomal Proteins, Non-Histone

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Chromosomal proteins --- -Gene expression --- -Genes --- Proteins, Chromosomal --- Nucleoproteins --- Gene expression --- Congresses. --- Congresses

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Nuclear Structure and Gene Expression assimilates the contributions of genome organization and of the components of the nuclear matrix to the control of DNA and RNA synthesis. Nuclear domains which accommodate DNA replication and gene expression are considered in relation to short-term developmental and homeostatic requirements as well as to long-term commitments to phenotypic gene expression in differentiated cells. Consideration is given to the involvement of nuclear structure in gene localization as well as to the targeting and concentration of transcription factors. Aberrations in n

Nuclear matrix. --- Gene expression. --- Genes --- Nuclear protein matrix --- Nuclear scaffold --- Nuclear skeleton --- Nucleoskeleton --- Expression --- Genetic regulation --- Cell nuclei --- Nonhistone chromosomal proteins

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Telomeres and telomerase are the pivotal players that destine cellular senescence and immortalization. Telomere shortening due to "End-replication problem" in each cell cycle is a universal phenomenon for all eukaryotic cells with linear chromosomes. Its compensation by telomerase is also common from yeast to human. However, the length of telomeres, distribution of telomerase positive cells, and consequence of telomerase inhibition are different among species. "Telomeres and Telomerase in Cancers", edited by Keiko Hiyama, focuses on "Human" telomeres and telomerase, from basic biology and hypothesis in human normal cells and cancer cells to clinical application as diagnostic tools and therapeutic targets in anti-cancer strategy. Cutting-edge experimental protocols for their evaluation are also included. This coverage will enable medical oncologists and students as well as basic researchers to capture the up-to-date entire picture of human telomeres and telomerase in cancer.

Antineoplastic agents --- Cancer --- Cell transformation, Neoplastic. --- Neoplasms --- Telomerase. --- Telomere --- Telomerase --- Cell Transformation, Neoplastic --- Telomere-Binding Proteins --- Antineoplastic Agents --- Genetics --- Drug Therapy --- Ribonucleoproteins --- Neoplastic Processes --- Therapeutic Uses --- Diseases --- Therapeutics --- Chromosome Structures --- Biology --- DNA-Binding Proteins --- Chromosomal Proteins, Non-Histone --- RNA-Directed DNA Polymerase --- Nuclear Proteins --- DNA-Directed DNA Polymerase --- Pathologic Processes --- RNA-Binding Proteins --- Proteins --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Pharmacologic Actions --- Biological Science Disciplines --- Genetic Structures --- Chromosomes --- Natural Science Disciplines --- Pathological Conditions, Signs and Symptoms --- Amino Acids, Peptides, and Proteins --- Nucleoproteins --- DNA Nucleotidyltransferases --- Genetic Phenomena --- Intranuclear Space --- Carrier Proteins --- Chemical Actions and Uses --- Chemicals and Drugs --- Cell Nucleus Structures --- Nucleotidyltransferases --- Disciplines and Occupations --- Phenomena and Processes --- Cell Nucleus --- Phosphotransferases --- Intracellular Space --- Transferases --- Enzymes --- Cellular Structures --- Enzymes and Coenzymes --- Cells --- Anatomy --- Oncology --- Medicine --- Health & Biological Sciences --- Therapeutic use. --- Molecular aspects. --- Drug therapy. --- Genetics. --- Molecular aspects --- Telomere. --- Medicine. --- Cancer research. --- Pharmacology. --- Oncology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Tumors --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Physiological effect --- DNA polymerases --- Oncology  . --- Toxicology. --- Pharmacology --- Poisoning --- Poisons --- Toxicology