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“Only once in a great while does a book come along that really does the job in addressing a major medical issue. When this happens, all can be joyful… Readers will find ALL their favorite dietary puzzlements dealt with… With consummate scholarship, clarity and brevity, Truswell sifts out the chaff and identifies the critical questions, the responsible investigators, and the key studies.” So says Emeritus Professor Henry Blackburn from the University of Minnesota in the foreword to this remarkable concise book on the history of research on diet and heart disease. This was a theme of scientific, medical and public interest in the 20th Century, a century marked by the rise and fall of coronary heart disease as the major cause of death in the first world, followed by the rise of this cause of death in the developing world. There is obviously much to learn, and this book is an excellent starting point, tracing dietary factors and their role in heart disease one by one: fats, sugar, salt, alcohol, coffee, trans-fats, etc. Without an understanding of the role of diet and the changes that have been seen in the North American and NW European diet, the story of the decline in the heart disease death rate may have been very different.

Cholesterol -- Physiological effect. --- Heart -- Diseases -- Prevention. --- Hypercholesteremia -- Prevention. --- Coronary heart disease --- Heart --- Cholesterol --- Myocardial Ischemia --- Dietary Fats --- Diet --- Cholesterol, Dietary --- Diet, Atherogenic --- Coronary Disease --- Fats --- Vascular Diseases --- Heart Diseases --- Investigative Techniques --- Sterols --- Lipids --- Cardiovascular Diseases --- Membrane Lipids --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Diseases --- Chemicals and Drugs --- Medicine --- Public Health --- Public Health - General --- Health & Biological Sciences --- Nutritional aspects --- Health aspects --- Coronary heart disease. --- Cholesterol. --- Cholesterin --- Coronary arteries --- Coronary arteriosclerosis --- Coronary disease --- Coronary thrombosis --- Ischemic heart disease --- Myocardial ischemia --- Medicine. --- Nutrition. --- Public health. --- Cardiology. --- Lipids. --- Medicine & Public Health. --- Public Health. --- History of Medicine. --- Lipidology. --- History. --- Isopentenoids --- Low-cholesterol diet --- Type A behavior --- Lipides --- Lipins --- Lipoids --- Biomolecules --- Steroids --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Alimentation --- Food --- Nutrition --- Health --- Physiology --- Dietetics --- Digestion --- Food habits --- Malnutrition --- Internal medicine --- Health Workforce --- Nutrition   . --- Medicine—History. --- Community health --- Health services --- Hygiene, Public --- Hygiene, Social --- Public health services --- Public hygiene --- Social hygiene --- Human services --- Biosecurity --- Health literacy --- Medicine, Preventive --- National health services --- Sanitation

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Today, in the era of the statins (cholesterol lowering drugs), there is no longer any doubt about the value of lowering blood cholesterol levels. This book chronicles the controversy that swirled around the 'lipid hypothesis' of atherosclerosis for so many years. In fact, 'the lower the better' is the position of many clinicians. However, getting to this point has been a long uphill battle marked by heated debate and sometimes violent disagreement. The history of this controversy is told here for its own sake and because remembering it may help us avoid similar mistakes in the future.

Atherosclerosis. --- Anticholesteremic agents. --- Statins (Cardiovascular agents) --- Hydroxymethylglutaryl coenzyme A reductases --- Statin drugs --- Anticholesterol drugs --- Antihypercholestermic agents --- Cholesterol inhibitors --- Cholesterol-lowering drugs --- Hypocholesteremic agents --- Inhibitors --- Anticholesteremic agents --- Enzyme inhibitors --- Antilipemic agents --- Arteriosclerosis --- Atherosclerosis --- Therapeutics --- Hypolipidemic Agents --- Hyperlipidemias --- Sterols --- Cholestenes --- Lipid Regulating Agents --- Membrane Lipids --- Dyslipidemias --- Cholestanes --- Antimetabolites --- Lipids --- Arterial Occlusive Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Steroids --- Chemicals and Drugs --- Molecular Mechanisms of Pharmacological Action --- Vascular Diseases --- Lipid Metabolism Disorders --- Therapeutic Uses --- Metabolic Diseases --- Pharmacologic Actions --- Polycyclic Compounds --- Cardiovascular Diseases --- Chemical Actions and Uses --- Nutritional and Metabolic Diseases --- Diseases --- Cholesterol --- Drug Therapy --- Hypercholesterolemia --- Anticholesteremic Agents --- Atherogenesis --- Atheroscleroses --- Chylomicron Remnants --- Plaque, Atherosclerotic --- Anticholesteremic Drugs --- Anticholesteremics --- Inhibitors, Cholesterol --- Cholesterol Inhibitors --- Hypocholesteremic Agents --- Agents, Anticholesteremic --- Agents, Hypocholesteremic --- Drugs, Anticholesteremic --- Elevated Cholesterol --- High Cholesterol Levels --- Hypercholesteremia --- Cholesterol Level, High --- Cholesterol Levels, High --- Cholesterol, Elevated --- Cholesterols, Elevated --- Elevated Cholesterols --- High Cholesterol Level --- Hypercholesteremias --- Hypercholesterolemias --- Level, High Cholesterol --- Levels, High Cholesterol --- Cholesterol, Dietary --- Therapy, Drug --- Chemotherapy --- Pharmacotherapy --- Chemotherapies --- Drug Therapies --- Pharmacotherapies --- Therapies, Drug --- Disease --- Pharmaceutical Preparations --- Epicholesterol --- Nutritional Physiological Phenomena --- Cardiovascular Disease --- Disease, Cardiovascular --- Diseases, Cardiovascular --- Cardiology --- Compounds, Polycyclic --- Hydrocarbons, Cyclic --- Chemical Actions --- Actions, Chemical --- Actions, Pharmacologic --- Pharmacological and Toxicological Phenomena --- Diseases, Metabolic --- Thesaurismosis --- Disease, Metabolic --- Metabolic Disease --- Thesaurismoses --- Therapeutic Effects --- Therapeutic Effect --- Therapeutic Use --- Effect, Therapeutic --- Effects, Therapeutic --- Use, Therapeutic --- Uses, Therapeutic --- Lipid Metabolism Disorder --- Metabolism Disorder, Lipid --- Metabolism Disorders, Lipid --- Disease, Vascular --- Diseases, Vascular --- Vascular Disease --- Pharmacological Mechanisms of Action --- Catatoxic Steroids --- Steroid --- Steroids, Catatoxic --- Arterial Obstructive Diseases --- Arterial Obstructive Disease --- Arterial Occlusive Disease --- Disease, Arterial Obstructive --- Disease, Arterial Occlusive --- Diseases, Arterial Obstructive --- Diseases, Arterial Occlusive --- Obstructive Disease, Arterial --- Obstructive Diseases, Arterial --- Occlusive Disease, Arterial --- Occlusive Diseases, Arterial --- Lipid --- Antimetabolite --- Dyslipidemia --- Dyslipoproteinemias --- Dyslipoproteinemia --- Cell Membrane Lipid --- Cell Membrane Lipids --- Membrane Lipid --- Lipid, Cell Membrane --- Lipid, Membrane --- Lipids, Cell Membrane --- Lipids, Membrane --- Membrane Lipid, Cell --- Membrane Lipids, Cell --- Cell Membrane --- Membranes --- Lipid Regulating Drugs --- Agents, Lipid Regulating --- Drugs, Lipid Regulating --- Regulating Agents, Lipid --- Regulating Drugs, Lipid --- Sterol --- Antihyperlipemics --- Antihyperlipidemics --- Antilipemic Drugs --- Antilipemics --- Hypolipidemic Drugs --- Antihyperlipidemic --- Antilipemic --- Antilipemic Agents --- Antilipemic Drug --- Hypolipidemic Agent --- Hypolipidemic Drug --- Agent, Hypolipidemic --- Agents, Antilipemic --- Agents, Hypolipidemic --- Drug, Antilipemic --- Drug, Hypolipidemic --- Drugs, Antilipemic --- Drugs, Hypolipidemic --- Arterioscleroses --- Therapy --- Treatment --- Therapeutic --- Therapies --- Treatments --- Hyperlipidemia --- Lipemia --- Lipidemia --- Hyperlipemia --- Hyperlipemias --- Lipemias --- Lipidemias --- antagonists & inhibitors --- drug therapy --- therapeutic use --- therapy --- Statins (Cardiovascular agents). --- therapeutic use. --- drug therapy. --- etiology. --- adverse effects. --- complications.