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The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equili

Chloride channels. --- Chlorides --- Physiological transport. --- Chlorine compounds --- Halides --- Channels, Chloride --- Ion channels

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Bicarbonate ions --- Biological transport, Active --- Chloride channels --- Protons --- BIOCARBONATES --- BIOLOGICAL TRANSPORT, ACTIVE, physiology --- BIOLOGICAL TRANSPORT --- CHLORIDES --- PROTONS --- Physiological transport --- Congresses. --- pharmacokinetics --- Pharmacokinetics --- Biocarbonates --- Biological transport --- Biological transport, active, physiology --- Biological transport, active --- Chlorides --- Biological transport [Active ] --- Congresses --- BICARBONATES --- IONS --- BIOLOGICAL TRANSPORT, ACTIVE --- CONGRESSES