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À la fin du XXe siècle, de nombreuses crises de nature épidémique se sont enchaînées. La sécurité sanitaire est devenue un enjeu international réclamant une approche mondiale. L'épidémie de sida avait sonné l'alerte au début des années 1980. À la suite de la maladie de la vache folle au début des années 1990, puis de l'épidémie liée au SRAS et des attaques bioterroristes au début des années 2000, le risque infectieux épidémique a semblé prendre une allure de plus en plus inquiétante. Le Pr Didier Houssin a été au cœur de cet enchaînement, en particulier au moment de l'épidémie de chikungunya à La Réunion, de la grippe aviaire, puis de la pandémie grippale de 2009. Soucieux d'en tirer les leçons pour la sécurité future des populations, il en retrace ici les temps forts et dresse le bilan des réponses qui ont été apportées. La pandémie de 2009, marquée par une bonne dose de chance pour l'espèce humaine, ne doit pas susciter l'inaction et ainsi se transformer en piège. Elle doit, au contraire, être l'occasion de prolonger l'effort de préparation, dans l'éventualité d'un phénomène épidémique plus grave.

Epidemics --- Public Health Surveillance --- Disease Vectors --- prevention and control --- Épidémies --- Veille sanitaire --- Chikungunya --- Grippe aviaire --- Grippe porcine --- Prévention --- Épidémies. --- Veille sanitaire. --- Chikungunya. --- Grippe aviaire. --- Grippe porcine. --- Prévention. --- Disease Outbreaks. --- France --- Epidemics - prevention and control - France --- Public Health Surveillance - France --- Disease Vectors - prevention and control - France --- Disease Outbreaks --- Chikungunya virus --- Health surveys --- Influenza a virus, h1n1 subtype --- Influenza a virus, h5n1 subtype

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Viruses are microscopic agents that exist worldwide and are present in humans, animals, plants, and other living organisms in which they can cause devastating diseases. However, the advances of biotechnology and next-generation sequencing technologies have accelerated novel virus discovery, identification, sequencing, and manipulation, showing that they present unique characteristics that place them as valuable tools for a wide variety of biotechnological applications. Many applications of viruses have been used for agricultural purposes, namely concerning plant breeding and plant protection. Nevertheless, it is interesting to mention that plants have also many advantages to be used in vaccine production, such as the low cost and low risks they entail, showing once more the versatility of the use of viruses in biotechnology. Although it will obviously never be ignored that viruses are responsible for devastating diseases, it is clear that the more they are studied, the more possibilities they offer to us. They are now on the front line of the most revolutionizing techniques in several fields, providing advances that would not be possible without their existence. In this book there are presented studies that demonstrate the work developed using viruses in biotechnology. These studies were brought by experts that focus on the development and applications of many viruses in several fields, such as agriculture, the pharmaceutical industry, and medicine.

Technology: general issues --- Bacteriophage --- Salmonella --- biocontrol --- comparative genomics --- phage diversity --- grapevine --- apple latent spherical virus vector --- virus-induced flowering --- reduced generation time --- breeding of grapevine --- virus elimination --- Newcastle disease virus --- reverse genetics --- vaccines --- infectious diseases --- cancer --- porcine epidemic diarrhea virus --- VLP --- chemokines --- pig --- vaccine --- SARS-CoV-2 --- COVID-19 --- phages --- CRISPR --- viruses --- prevention --- diagnosis --- treatment --- adeno-associated virus (AAV) vector --- jaagsiekte sheep retrovirus (JSRV) --- LTR --- enhancer --- transduction --- viral vaccines --- cancers --- COVID-19 vaccines --- self-replicating RNA vectors --- DNA-based vaccines --- RNA-based vaccines --- plant virus --- viroid --- viral vector --- virus-induced gene silencing (VIGS) --- CRISPR/Cas9 --- genome editing --- carotenoid biosynthesis --- circular RNA --- infectious bursal disease virus --- immunization --- recombinant Lactococcus lactis --- variant strain --- baculovirus --- insect cells --- bacmid --- Tn7 --- genome stability --- protein expression --- chikungunya virus --- VLPs --- bioreactor --- CRISPR/Cas systems --- viral vectors --- gene editing --- plant genome engineering --- viral resistance --- adeno-associated virus --- AAV --- cancer gene therapy --- prophage --- hydrothermal vent --- Hypnocyclicus thermotrophus --- lytic cassette --- Escherichia coli --- heterologous expression --- codon optimization --- codon harmonization --- expression vectors --- aspect ratio --- VNPs --- TMV --- PVX --- CPMV --- geminivirus --- theranostics --- CRISPR-cas9 --- clodronate --- macrophage --- gene therapy --- gene expression --- nanotechnology

Choose an application

• Reference Manager
• EndNote
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Viruses are microscopic agents that exist worldwide and are present in humans, animals, plants, and other living organisms in which they can cause devastating diseases. However, the advances of biotechnology and next-generation sequencing technologies have accelerated novel virus discovery, identification, sequencing, and manipulation, showing that they present unique characteristics that place them as valuable tools for a wide variety of biotechnological applications. Many applications of viruses have been used for agricultural purposes, namely concerning plant breeding and plant protection. Nevertheless, it is interesting to mention that plants have also many advantages to be used in vaccine production, such as the low cost and low risks they entail, showing once more the versatility of the use of viruses in biotechnology. Although it will obviously never be ignored that viruses are responsible for devastating diseases, it is clear that the more they are studied, the more possibilities they offer to us. They are now on the front line of the most revolutionizing techniques in several fields, providing advances that would not be possible without their existence. In this book there are presented studies that demonstrate the work developed using viruses in biotechnology. These studies were brought by experts that focus on the development and applications of many viruses in several fields, such as agriculture, the pharmaceutical industry, and medicine.

Technology: general issues --- Bacteriophage --- Salmonella --- biocontrol --- comparative genomics --- phage diversity --- grapevine --- apple latent spherical virus vector --- virus-induced flowering --- reduced generation time --- breeding of grapevine --- virus elimination --- Newcastle disease virus --- reverse genetics --- vaccines --- infectious diseases --- cancer --- porcine epidemic diarrhea virus --- VLP --- chemokines --- pig --- vaccine --- SARS-CoV-2 --- COVID-19 --- phages --- CRISPR --- viruses --- prevention --- diagnosis --- treatment --- adeno-associated virus (AAV) vector --- jaagsiekte sheep retrovirus (JSRV) --- LTR --- enhancer --- transduction --- viral vaccines --- cancers --- COVID-19 vaccines --- self-replicating RNA vectors --- DNA-based vaccines --- RNA-based vaccines --- plant virus --- viroid --- viral vector --- virus-induced gene silencing (VIGS) --- CRISPR/Cas9 --- genome editing --- carotenoid biosynthesis --- circular RNA --- infectious bursal disease virus --- immunization --- recombinant Lactococcus lactis --- variant strain --- baculovirus --- insect cells --- bacmid --- Tn7 --- genome stability --- protein expression --- chikungunya virus --- VLPs --- bioreactor --- CRISPR/Cas systems --- viral vectors --- gene editing --- plant genome engineering --- viral resistance --- adeno-associated virus --- AAV --- cancer gene therapy --- prophage --- hydrothermal vent --- Hypnocyclicus thermotrophus --- lytic cassette --- Escherichia coli --- heterologous expression --- codon optimization --- codon harmonization --- expression vectors --- aspect ratio --- VNPs --- TMV --- PVX --- CPMV --- geminivirus --- theranostics --- CRISPR-cas9 --- clodronate --- macrophage --- gene therapy --- gene expression --- nanotechnology