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Originally published in 2005, this book reviews understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecular chaperones, their role in the cellular response to stress and their disposition within the cell. It also questions the basic paradigm of molecular chaperone biology - that these proteins are first and foremost protein-folding molecules. Paradigms of protein secretion are reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting proteins' has been introduced is discussed. The role of exogenous molecular chaperones as cell regulators is examined and the physiological and pathophysiological role that molecular chaperones play is described. In the final section, the potential therapeutic use of molecular chaperones is described and the final chapter asks the question - what does the future hold for the extracellular biology of molecular chaperones?

Molecular chaperones. --- Chaperone proteins --- Chaperones, Molecular --- Chaperonins --- Proteins

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The first of its kind, this volume presents the latest research findings on the chaperonins, the best studied family of a class of proteins known as molecular chaperones. These findings are changing our view of some fundamental cellular processes involving proteins, especially how proteins fold into their functional conformations.Key Features* Origins of the new view of protein folding* Prokaryotic chaperonins* Eukaryotic chaperonins* Evolution of the chaperonins* Refolding of denatured proteins* Organelle biosynthesis* Biomedical aspects

Molecular chaperones. --- Proteins. --- Chaperone proteins --- Chaperones, Molecular --- Chaperonins --- Proteins --- Proteids --- Biomolecules --- Polypeptides --- Proteomics

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The precise shape of a protein is a crucial factor in its function. Molecular chaperones and protein folding catalysts bind to develop proteins in the cell and ensure correct folding and transport. This guide catalogues 200 such molecules.

Molecular chaperones. --- Protein folding. --- Folding of proteins --- Proteins --- Chaperone proteins --- Chaperones, Molecular --- Chaperonins --- Folding --- Conformation --- Catalysts --- Molecular chaperones --- Protein folding

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In Chaperonin Protocols, Christine Schneider has assembled a unique collection of readily reproducible protocols for the study of chaperonins, intracellular proteins critical to many biological processes. Written by experienced investigators who have successfully honed their methods to a fineness, the protocols focus on the purification of chaperonins from different species along with their corresponding cofactors, and on chaperonin activity assays for in vivo as well as in vitro work. Many activity assays are given for GroEL, which can also be applied to mitochrondrial Hsp60. There are also assays for the eukaryotic chaperonin TRiC and handy methods-for example, one for preparing labeled probes-that can be used for various purposes and prove helpful in numerous different procedures. Critically important to a greater understanding of such disorders as cystic fibrosis, Alzheimer's disease, and BSE, Chaperonin Protocols offers both novice and experienced investigators fast access to today's best and most productive chaperonin methods, all explained in step-by-step detail to ensure robust and reproducible results.

Molecular chaperones --- Purification --- Molecular biology. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Chaperone proteins --- Chaperones, Molecular --- Chaperonins --- Proteins --- Biochemistry. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition

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  The book Heat Shock Protein-Based Therapies provides the most up-to-date review on new heat shock protein-based mechanisms used in the therapy and treatment of various human disorders and diseases, including cancer, muscular atrophy, neurodegenerative disorders (Alzheimer's Disease, Multiple Sclerosis) and infectious diseases (HIV, periodontal disease). Written by leaders in the field of heat shock protein research, the chapters systematically and in a step wise fashion takes the reader through the fascinating sequence of events by which mechanisms dependent on heat shock proteins are targeted. The chapters also provide answers as to HSP biological significance to the host. This book is a must read for graduate and postgraduates in the field of Drug Development, Biotechnology, Pharmaceutical Industry, Phytomedicine, Biology (plant and mammal), Biochemistry (pro- and eukaryotic), Oncology, Immunology, Microbiology, Exercise Medicine, Physiology, Inflammatory diseases, Autoimmunity, Pharmacology and Pathology.

Biomedicine. --- Biomedicine general. --- Life Sciences, general. --- Science, general. --- Medicine/Public Health, general. --- Medicine. --- Science (General). --- Life sciences. --- Médecine --- Sciences de la vie --- Molecular chaperones. --- Proteins -- Physiological transport. --- Proteins --- Physiological transport. --- Chaperone proteins --- Chaperones, Molecular --- Chaperonins --- Science. --- Science, Humanities and Social Sciences, multidisciplinary. --- Biosciences --- Sciences, Life --- Science --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biomedicine, general. --- Health Workforce