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Calcium --- Ion Exchange. --- Sodium --- Exchange, Ion --- metabolism. --- Calcium channels --- Sodium channels --- Congresses. --- Ion Exchange --- Channels, Sodium --- Ion channels --- Congresses --- metabolism --- Physiological transport

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A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

Ion channels --- Sodium channels. --- Research --- Methodology. --- Channels, Sodium --- Sodium --- Channels, Ion --- Biological transport, Active --- Ion-permeable membranes --- Membrane proteins --- Physiological transport --- Toxicology. --- Neurosciences. --- Cardiology. --- Cell membranes. --- Biochemistry. --- Pharmacology/Toxicology. --- Membrane Biology. --- Protein Structure. --- Heart --- Internal medicine --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Diseases --- Toxicology --- Composition --- Pharmacology. --- Cell membranes . --- Proteins . --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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This book reports the text of the lectures of the 6th International Conference on Sodium Calcium Exchange held in Lacco Ameno in the Island of Ischia in the Gulf of Naples, Italy, from October 1 to October 5, 2011. The present book uncovers the most striking new findings on NCX that emerged since the previous Conference on Sodium Calcium Exchange, such as the structural dissection of the molecular determinants of Ca2+ sensitivity of the exchanger, the epigenetic regulation of ncx1 gene, the molecular identification of the mitochondrial Sodium Calcium Exchanger, and the discovery of NCX in unexpected anatomical locations such as the female reproductive tract. The book is organized into 11 parts covering NCX structural aspects, genetic and epigenetic regulation, regulatory mechanisms, subcellular localization in mitochondria, involvement in neurodegenerative diseases and in immune regulation, and the role of the cardiovascular and endocrine systems, as well as diabetes in physiology and pathophysiology. Selected chapters of the book are also devoted to the interaction of NCKX and other ion channels and transporters with NCX, like ASICs, TRPM, and NHE.   Lucio Annunziato is Professor of Pharmacology and chairman of the Department of Neuroscience in the School of Medicine at the “Federico II” University of Naples, Italy. He is coordinator of the University’s Neuroscience Ph.D. program. He is also past-president of the Italian Society for Neuroscience. Dr. Annunziato has authored more that 190 full papers in peer reviewed international journals in the field of neuroscience and molecular pharmacology of plasmamembrane transporters and ionic channels involved in the pathophysiology of stroke and other neurodegenerative diseases. .

Calcium channels -- Congresses. --- Magnesium -- Metabolism -- Congresses. --- Sodium channels -- Congresses. --- Sodium channels --- Calcium channels --- Publication Formats --- Ion Channels --- Antiporters --- Metals, Alkaline Earth --- Metals, Alkali --- Physicochemical Processes --- Blood Coagulation Factors --- Metabolic Phenomena --- Physicochemical Phenomena --- Metals --- Elements --- Chemical Processes --- Ion Pumps --- Membrane Transport Proteins --- Biological Factors --- Phenomena and Processes --- Membrane Glycoproteins --- Publication Characteristics --- Inorganic Chemicals --- Carrier Proteins --- Chemical Phenomena --- Chemicals and Drugs --- Membrane Proteins --- Proteins --- Amino Acids, Peptides, and Proteins --- Calcium --- Sodium-Calcium Exchanger --- Calcium Channels --- Sodium --- Ion Exchange --- Metabolism --- Congresses --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Neurology --- Medical Research --- Animal Biochemistry --- Sodium cotransport systems --- Cotransport systems, Sodium --- Channels, Sodium --- Medicine. --- Immunology. --- Neurosciences. --- Cardiology. --- Endocrinology. --- Biomedicine. --- Internal medicine --- Hormones --- Heart --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Pathology --- Physicians --- Diseases --- Biological transport, Active --- Ion channels --- Physiological transport --- Endocrinology .