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Sphingolipids --- Ceramides --- Physiological effect. --- Physiological effect.

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

nutrient sensing --- energy balance --- hypothalamus --- olfactory bulb --- melanocortin system --- polyunsaturated fatty acids --- ceramides --- neural stem cells

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Science: general issues --- Physiology --- nutrient sensing --- energy balance --- hypothalamus --- olfactory bulb --- melanocortin system --- polyunsaturated fatty acids --- ceramides --- neural stem cells

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This book is about the various roles of bioactive ceramides and other sphingolipids in cellular biology. The enigmatic biophysical and biochemical properties of ceramides and their propensity to influence membranes whether as rafts or protein-permeable channels are heavily discussed. Metabolism of ceramides and their metabolites is also focused with ceramide synthase family of proteins being a target of extensive review. Ceramide 1-phosphate and other sphingolipids are also presented in cellular physiology and pathophysiology. Prokaryotic origins of mitochondria at the level of membranes and the occurrence of apoptosis in bacteria are presented. Many aspects of ceramide and sphingolipid biology are addressed in this book. Its focus is the metabolism of ceramide in normal and diseased states and the biophysical and biochemical mechanisms governing the bioactivity of these molecules. Sphingolipid research has surged over the past thirty years and this book gathers the recent findings of various aspects of sphingolipid biochemistry. World-renowned scientists from the field of lipid biology, specifically sphingolipid biochemistry, were gathered to write this book. Scholars from most continents of the globe committed to write diligently about their expertise and the newest findings in the relevant fields. This book came to fruition after almost a year and a half of laborious preparation and diligent writings. This book is targeted to the experienced reader who is looking to read about the various aspects of bioactive ceramide signaling, as well as to the newcomer into the field, as the topics are explained in concise yet very informative manner. The authors and editor wish all readers a pleasant time reading this volume, and are adamant that this book will meet all expectations. .

Ceramides. --- Medicine. --- Lipids. --- Oncology. --- Biomedical engineering. --- Molecular Medicine. --- Lipidology. --- Cancer Research. --- Biomedical Engineering/Biotechnology. --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Tumors --- Lipides --- Lipins --- Lipoids --- Biomolecules --- Steroids --- Health Workforce --- Molecular biology. --- Cancer research. --- Cancer research --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Systems biology

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The book largely reflect the structural diversity of echinoderm metabolites including triterpene glycosides and fucosylated chondroitin sulfates, as well as branched fatty acids, di- and triacylglycerols and other lipid classes from the sea cucumbers, polyhydroxysteroids from starfish and different classes of sphingolipids from sea cucumbers and starfish. Finally, the MS-based metabolomic approach, which is very helpful for the estimation of such diversity, is discussed. The materials from the Special Issue also illustrate the biomedical potential of the presented metabolites as cytotoxins and anticoagulants. The in silico approach broadens the possibilities to investigate the mechanisms of the action of membranolytic compounds.

Research & information: general --- Chemistry --- diacylglycerol ether --- 1-O-alkylglyceryl ether --- nutraceutical oils --- bêche-de-mer --- sea cucumber --- Bohadschia argus --- Holothuria (Theelothuria) spinifera --- fucosylated chondroitinsulfates --- fucan sulfates --- anticoagulant activity --- disulfated steroids --- NMR spectra --- starfish --- Pteraster marsippus --- cytotoxic activity --- 3D culture --- Psolus chitonoides --- triterpene glycosides --- chitonoidosides ---   triterpene glycosides --- membranolytic action --- hemolytic --- molecular dynamic simulation --- Thyonidium kurilensis --- kurilosides --- polyhydroxysteroids --- steroid glycosides --- lipids --- mass spectrometry --- metabolomics --- metabolomic profiling --- sphingolipids --- ceramides --- cerebrosides --- gangliosides --- sialic acid --- Asteroidea --- Holothuroidea --- biological activity --- neuritogenic activity ---