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Central Nervous System disorders have an enormous impact on individuals and on society as a whole. The development of better treatments is crucial and is a major focus of pharmaceutical and biotechnology companies. This book explains the complicated process of CNS drug development in a way that is engaging for any interested professional or student. Chapters cover each stage of drug development, from pre-clinical research through all phases of clinical trials, to reporting to the regulatory authorities. Other key issues covered include strategic considerations, regulatory constraints, dissemination of results and ethical considerations. The user-friendly format and style enable readers to find important information quickly and easily. Written and edited by experts from different sectors actively engaged in CNS drug development, this is a unique resource for drug developers, investigators, academics and clinicians.

Central nervous system stimulants --- Development. --- Drug development.

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Pharmacology. Therapy --- Amphetamines --- Congresses --- Conferences - Meetings --- Appetite depressants --- Central nervous system stimulants --- Phenethylamines --- Sympathomimetic agents

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Central Nervous System Stimulants --- Substance-Related Disorders --- Hypnotics and Sedatives --- Psychotropic Drugs --- pharmacology

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Neuroenhancement (NE) is a behavior conceptualized as the use of a potentially psychoactive substance to enhance ones’ already proficient cognitive capacities. Depending on the specific definitions used, prevalence estimates vary greatly between very low 0.3% (for illicit substances) to astonishingly high 89% (for freely available lifestyle substances). These variations indicate that further research and more conceptual and theoretical clarification of the NE construct is dearly needed. The contributions of this research topic aim to do just that. Specific questions addressed are: How prevalent is NE behavior? How can NE research profit from the already more evolved field of social science research on doping in sports? How is NE perceived by the public? What psychological processes and variables play a role in the decision to neuroenhance? A wide array of methodological approaches is used to investigate these questions. The topics contributions range from theoretical to experimental accounts on NE, and they utilize a diverse set of methods ranging from qualitative to neuroscientific approaches. The research presented here represents a first step towards what we have labeled a psychological approach to NE. By addressing the questions above this research topic hopefully advances our understanding of NE behavior. As with every new field of research, new answers always prompt new questions. In light of what we know now about NE, we hope that the findings presented here will be pursued by other researchers in the future. Clearly, the endeavor to understand NE behavior has only just begun.

Brain chemistry. --- Central nervous system stimulants. --- neuroenhancement --- performance enhancement --- Doping --- Behavior --- cognitive enhancement

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"Sleep Deprivation: Stimulant Medications and Cognition provides a review, synthesis and analysis of the scientific literature concerning stimulant medications and neurobehavioral performance, with an emphasis on critically evaluating the practical utility of these agents for maintaining cognitive performance and alertness in sleep-deprived (but otherwise healthy) individuals. The book explores the nature of sleep loss-induced cognitive deficits, neurophysiologic basis of these deficits, relative efficacy and limitations of various interventions (including non-pharmacological), and implications for applying these interventions in operational environments (commercial and military). Readers of this volume will gain a working knowledge of: [bullet] Mechanisms contributing to sleep loss-induced cognitive deficits [bullet] Differential effects of stimulant compounds on various aspects of cognition [bullet] Considerations (such as abuse liability) when applying stimulant interventions in operational settings [bullet] Current state and future directions for including stimulants in comprehensive fatigue-management strategies. This text is key reading for researchers and trainees in sleep and psychopharmacology"--Provided by publisher.

Sleep Deprivation. --- Central Nervous System Stimulants --- Cognition --- Neurobehavioral Manifestations. --- Sommeil --- Psychostimulants. --- Cognition. --- adverse effects. --- drug effects. --- Privation.