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Psychopharmacology --- Psychopharmacologie --- Mental Disorders --- Neurobiology --- Psychotropic Drugs --- Central Nervous System --- drug therapy --- drug effects --- Psychopharmacology. --- Mental Disorders - drug therapy --- Central Nervous System - drug effects
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La Psychopharmacologie essentielle est devenue l'ouvrage de référence en psychopharmacologie et demeure une source d'informations majeure dans ce domaine. Cette nouvelle édition, entièrement revue et augmentée, intègre les avancées de la recherche en neurobiologie et leurs applications thérapeutiques médicamenteuses pour expliquer, de façon claire et accessible, les concepts qui sous-tendent le traitement des troubles psychiatriques. Les progrès cliniques des traitements antipsychotiques et antidépresseurs sont discutés en détail, et des chapitres spécifiques sont consacrés aux troubles du sommeil, à l'obésité, aux addictions, à la douleur chronique et aux troubles du contrôle des impulsions. L'ouvrage comporte également quatre nouveaux chapitres sur la génétique en psychiatrie, la prise en charge de la douleur, le traitement des troubles cognitifs et celui des troubles du sommeil. La rédaction, toujours claire, est illustrée de nombreux schémas entièrement redessinés et considérablement enrichis, réussissant ainsi, ce qui constitue un véritable défi pédagogique, à rendre attrayantes et accessibles des notions de physiologie, physiopathologie et pharmacologie souvent arides.
Psychopharmacology --- Psychopharmacologie --- Mental Disorders --- Neurobiology --- Psychotropic Drugs --- Central Nervous System --- drug therapy --- drug effects --- Psychopharmacology. --- Mental Disorders - drug therapy --- Central Nervous System - drug effects
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Central nervous system --- Central nervous system, drug effects. --- Mental disorders --- Mental disorders, drug therapy. --- Neuropsychopharmacology. --- Psychotropic drugs --- Drug effects. --- Drug therapy. --- Pharmacology.
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La Psychopharmacologie essentielle est devenue l'ouvrage de référence en psychopharmacologie et demeure une source d'informations majeure dans ce domaine. Cette nouvelle édition, entièrement revue et augmentée, intègre les avancées de la recherche en neurobiologie et leurs applications thérapeutiques médicamenteuses pour expliquer, de façon claire et accessible, les concepts qui sous-tendent le traitement des troubles psychiatriques. Les progrès cliniques des traitements antipsychotiques et antidépresseurs sont discutés en détail, et des chapitres spécifiques sont consacrés aux troubles du sommeil, à l'obésité, aux addictions, à la douleur chronique et aux troubles du contrôle des impulsions. L'ouvrage comporte également quatre nouveaux chapitres sur la génétique en psychiatrie, la prise en charge de la douleur, le traitement des troubles cognitifs et celui des troubles du sommeil. La rédaction, toujours claire, est illustrée de nombreux schémas entièrement redessinés et considérablement enrichis, réussissant ainsi, ce qui constitue un véritable défi pédagogique, à rendre attrayantes et accessibles des notions de physiologie, physiopathologie et pharmacologie souvent arides.
Psychopharmacologie --- Psychopharmacology. --- Psychopharmacology --- Psychotropic Drugs --- Mental Disorders --- drug therapy. --- Psychotropic Drugs. --- Psychopharmacologie. --- Neurobiology --- Central Nervous System --- drug therapy --- drug effects --- Mental Disorders - drug therapy --- Central Nervous System - drug effects
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The two greatest medical fears of the aging population are cancer and Alzheimer’s disease. Despite dramatic advances in understanding the molecular etiology of these disorders, therapeutic options for many patients with advanced disease have changed little and outcomes remain dismal. Paradoxically, recent findings suggest that some of the same molecules and biochemical processes underlying cancer may also participate in neurodegeneration. Therefore, it would be very useful to bring together experts from the fields of cancer research and neurodegeneration for discussions of the latest advances and ideas, with a particular emphasis on areas of overlap, to stimulate transdisciplinary interactions with the hope of accelerating progress. Cancer arises as a consequence of a breakdown in the genetic and epigenetic processes governing cell proliferation and cell death. Alterations in several classes of signaling molecules, both oncogenes and tumor suppressor genes, lead to uncontrolled cell growth. Over the past two decades, details of the intricate signaling pathways, from cell surface receptors through protein kinase cascades, transcription factors and modulators of chromatin, as well as the DNA damage response pathways linked to cell cycle control that guard the genome, have been uncovered. In some instances, key regulatory proteins have provided novel targets for development of small molecule inhibitors that are currently being tested in the clinic. The development of the nervous system relies on many of the signaling pathways and growth control processes that go awry in cancer. However, in mature neurons, the very same signaling proteins participate in transduction cascades linking short-term stimuli, elicited by synaptic stimulation, to long-term alterations in neuronal circuits through the regulation of gene expression and chromatin structure. These long-term adaptive modifications lead to changes in synaptic structure and function that contribute to learning and memory. The persistence of growth regulatory molecules in postmitotic neurons provides an opportunity for their contribution to pathophysiological processes resulting in neuronal loss. Recently, evidence has accumulated suggesting an association of cell cycle proteins and signal transduction proteins with neurodegeneration. Indeed, inhibitors of histone deacetylation have shown promise both as anti-cancer agents and in the prevention of neuronal loss.
Cancer. --- Central Nervous System -- Drug effects. --- Central Nervous System -- Metabolism. --- Hormones -- Metabolism. --- Hormones -- Physiology. --- Neoplasms. --- Nervous system -- Degeneration -- Endocrine aspects. --- Dementia --- Tauopathies --- Physiological Processes --- Cell Growth Processes --- Pathologic Processes --- Diseases --- Cell Physiological Processes --- Physiological Phenomena --- Cell Physiological Phenomena --- Pathological Conditions, Signs and Symptoms --- Brain Diseases --- Delirium, Dementia, Amnestic, Cognitive Disorders --- Neurodegenerative Diseases --- Growth --- Central Nervous System Diseases --- Nervous System Diseases --- Mental Disorders --- Growth and Development --- Phenomena and Processes --- Psychiatry and Psychology --- Alzheimer Disease --- Nerve Degeneration --- Cell Proliferation --- Homeostasis --- Cell Death --- Neoplasms --- Medicine --- Health & Biological Sciences --- Neurology --- Nervous system --- Alzheimer's disease. --- Degeneration. --- Medicine. --- Cancer research. --- Neurosciences. --- Biomedicine. --- Cancer Research. --- Alzheimer disease --- Alzheimer's dementia --- Basal ganglia --- Presenile dementia --- Senile dementia --- Degeneration, Nerve --- Nerve degeneration --- Nervous system degeneration --- Neurodegenerative disease --- Neurodegenerative diseases --- Neurodegenerative disorders --- Neuron degeneration --- Nissl degeneration --- Retrograde degeneration --- Wallerian degeneration --- Degeneration (Pathology) --- Degeneration and regeneration --- Oncology. --- Tumors --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Cancer research
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Since the beginning of the 21st Century there has been a rapid increase in our understanding of the cellular trafficking mechanisms of molecular chaperones in eukaryotes and in prokaryotes. In the former, molecular chaperone trafficking can occur between the various cellular compartments, with concomitant movement of other proteins. Such events can also result in the release of molecular chaperones from cells. In bacteria, molecular chaperones are involved in the trafficking of other proteins and are themselves released into the external milieu. The increasing appreciation of the role of molecular chaperones and Protein-Folding Catalysts in the interplay between bacteria and the cells of their hosts is now an important area of research for understanding the mechanisms of infectious diseases. This volume brings together experts in the biochemistry, cellular biology, immunology and molecular biology of molecular chaperones and Protein-Folding Catalysts with a focus on the mechanisms of cellular trafficking of these proteins and the role of these variegated trafficking mechanisms in both human and animal health and disease.
Brain -- Wounds and injuries -- Pathophysiology. --- Central Nervous System -- drug effects. --- Central Nervous System -- injuries. --- Central nervous system -- Wounds and injuries -- Chemotherapy. --- Central nervous system -- Wounds and injuries -- Pathophysiology. --- Molecular chaperones --- Eukaryotic cells --- Prokaryotes --- Proteins --- Heat shock proteins --- Diseases --- Biological Science Disciplines --- Biological Transport --- Amino Acids, Peptides, and Proteins --- Metabolism --- Natural Science Disciplines --- Disciplines and Occupations --- Metabolic Phenomena --- Chemicals and Drugs --- Phenomena and Processes --- Physiology --- Protein Transport --- Heat-Shock Proteins --- Molecular Chaperones --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Physiological transport --- Molecular chaperones. --- Eukaryotic cells. --- Prokaryotes. --- Heat shock proteins. --- Diseases. --- Physiological transport. --- Human beings --- Illness --- Illnesses --- Morbidity --- Sickness --- Sicknesses --- Stress proteins --- Monera --- Procaryotae --- Procaryotes --- Prokaryonta --- Prokaryotae --- Prokaryotic protists --- Eucaryotic cells --- Chaperone proteins --- Chaperones, Molecular --- Chaperonins --- Medicine. --- Human physiology. --- Molecular biology. --- Neurosciences. --- Life sciences. --- Biomedicine. --- Human Physiology. --- Life Sciences, general. --- Molecular Medicine. --- Biosciences --- Sciences, Life --- Science --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Human biology --- Human body --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Medicine --- Epidemiology --- Health --- Sick --- Cells --- Protista --- Microorganisms --- Health Workforce
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