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This collection provides methods and techniques employed when culturing, manipulating, quantifying, and functionally assessing retinal ganglion cells (RGCs), vital for better understanding various ocular diseases and for developing novel therapies. The book features exhaustive and detailed protocols for the study of RGCs at both the in vitro and in vivo level, including the culture of rodent and human cells, and immunohistochemical, morphological, and functional assessments of various in vivo models of RGC death. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Retinal Ganglion Cells: Methods and Protocols serves as an ideal guide to these important cellular features of the central nervous system and the many traumatic and degenerative blinding diseases that affect them.

Neurophysiology. --- Neurons. --- Anatomy. --- Cytology. --- Cells. --- Cellular Neuroscience. --- Cell Types.

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This new book extensively explores a range of topics related to astrocyte-neuron interactions under multiple conditions, in both health and disease. These include the types of interactions that occur during development and the establishment of neuronal circuits that underlie learning and memory formation in various animal models as well as humans. Furthermore, the book addresses topics on how these interactions go awry in disease and injury. In addition, the authors propose inspiring new avenues to explore therapeutic approaches using astrocytes as targets. A cadre of international experts presents a broad range of views on the state-of-the-art of astrocyte-neuron interactions.

Neurosciences. --- Neurophysiology. --- Neurons. --- Neurology. --- Neuroscience. --- Cellular Neuroscience. --- Astrocytes.

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The cardiovascular system and the neuroendocrine system are integrated at multiple levels. This integration is key to normal physiological function. Further, it adapts to accommodate changes related to aging, the organism’s reproductive state, or physiological challenges. This type of adaptability, or plasticity, also can contribute to pathophysiology when these systems are stressed. This volume discusses how neuroendocrine systems influence cardiovascular function in health and disease. The first section provides detailed background information on neuronal and neuroendocrine control of cardiovascular function. This is followed by chapters highlighting the cardiovascular role of neuroendocrine hormones in regulating physiological states, such as pregnancy, and the effects of biological sex on vascular function. The influence of exercise, stress, psychology, and aging on cardiovascular function and dysfunction, and the possibility of therapeutically targeting the neuroendocrine axis for the treatment of cardiovascular disease are discussed in the final section of the book. This book is of relevance for students, trainees and established researchers alike who are seeking for an overview on the neuroendocrine control of cardiovascular function and disease. This is the fourteenth volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series, which aims to illustrate the highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology.

Neurophysiology. --- Neurons. --- Cardiovascular system. --- Physiology. --- Cardiology. --- Endocrinology. --- Cellular Neuroscience. --- Cardiovascular Physiology.

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This volume highlights current research on how the neuroendocrine system helps to influence emotional states and ultimately behavioral output. Social relationships and context-appropriate behavioral responses are important for the survival of most vertebrate species. These relationships can range from transient social interactions to strong social bonding between sexual partners and social behaviors can be observed and evaluated from the individual- to the group-level. Further, behavioral output is shaped by complex interactions between the physical environment, genetics, experience, and context, and are often modulated by the neuroendocrine system. In this book, experts in the field will provide a sweeping look at novel research in the neuroendocrine regulation of important behaviors ranging from parental care to social homeostasis, with a focus on comparative studies across vertebrate species. The first part of the book is dedicated to the neuroendocrinology of relationships, including the coordination of acoustic signals in songbirds, the complexity of social relationships in primates, and cooperation and parenting in humans. The second part of the book focuses on social behaviors and provides some insights into their regulation, including the neuroendocrine regulation of maternal behavior in rodents, the roles of oxytocin and vasopressin in the modulation of sex-specific social behavior, the interactions between adult neurogenesis, the neuroendocrine system and social behavior, and a consideration of neuroendocrine influences on reproductive decision making across species. The book concludes with a section on environmental influences on neuroendocrine systems underlying behavior, including how social isolation and endocrine disrupting chemicals affect the neuroendocrinology of behavior and emotions. Given its breadth, this volume is appropriate for undergraduate students, graduate students, postdoctoral researchers, and established researchers who are interested in neuroendocrinology and behavior. This is the sixteenth volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series, which aims to illustrate the highest standards and highlight the latest technologies in basic and clinical research and aspires to provide inspiration for further exploration into the exciting field of neuroendocrinology.

Psychobiology. --- Human behavior. --- Neurophysiology. --- Neurons. --- Social psychology. --- Endocrinology. --- Behavioral Neuroscience. --- Cellular Neuroscience. --- Social Psychology.

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This book provides a comprehensive understanding of cellular senescence, which is a phenomenon, characterized by the irreversible arrest of cell growth and is accompanied by the secretion of various factors, collectively known as the senescence-associated secretory phenotype (SASP), which can have detrimental effects on surrounding cells and tissues. The book examines the role of cellular senescence as a driver of age-related disorders such as cancer, neurodegenerative diseases, cardiovascular conditions, and metabolic disorders. By elucidating the molecular mechanisms involved, the book aims to deepen our understanding of these complex diseases and identify potential therapeutic targets. The book also explores cutting-edge therapeutic modalities that target cellular senescence, ranging from small molecule inhibitors to gene-based therapies and regenerative approaches. The distinctive features of the book include its comprehensive approach, integration of multidisciplinary expertise, in-depth exploration of therapeutic modalities, evidence-based insights supported by scientific research, and a translational focus. The interdisciplinary collaboration ensures a holistic understanding of the subject matter, fostering a synergistic approach to addressing age-related disorders. The book not only discusses the potential of emerging therapeutic modalities but also emphasizes practical implications, providing a bridge between research and real-world applications. This book is useful to researchers, scientists, and academics in the fields of molecular biology, genetics, gerontology, and cellular biology.

Medicine --- Biology --- Clinical biochemistry. --- Neuropharmacology. --- Cytology. --- Aging. --- Neurophysiology. --- Neurons. --- Biomedical Research. --- Medical Biochemistry. --- Cellular Senescence. --- Cellular Neuroscience. --- Research.