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The potential of stem cells for healing and disease prevention in all fields of medicine is tremendous and has revolutionized the high-tech biomedical research. In this book, many of the most prominent researchers discuss the challenging topics of stem cell engineering, for example: Ethical issues of stem cell research; technological challenges, stem cell growth and differentiation, therapeutic applications, bioreactors and bioprocesses, high throughput and microfluidic screening platforms, stem cell identification and sorting, intercellular signaling and engineered niches, novel approaches for embryonic and adult stem cell growth and differentiation, stem cells and drug discovery, screening platforms. Stem Cell Engineering offers valuable background and reference for both the public and professionals including industrial staffers, faculty, researchers, engineers, students and scientific journalists.
Biomedical engineering. --- Biotechnology. --- Cytology. --- Engineering. --- Stem cells --Transplantation --Moral and ethical aspects. --- Stem cells --Transplantation. --- Stem cells. --- Stem cells --- Biomedical Research --- Investigative Techniques --- Cells --- Culture Techniques --- Clinical Laboratory Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Anatomy --- Research --- Stem Cell Research --- Stem Cells --- Tissue Engineering --- Science --- Natural Science Disciplines --- Disciplines and Occupations --- Biology --- Health & Biological Sciences --- Biomedical Engineering --- Cytology --- Transplantation --- Moral and ethical aspects --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cell biology. --- Biomedical Engineering. --- Cell Biology. --- Biomedical Engineering and Bioengineering. --- Chemical engineering --- Genetic engineering --- Cell biology --- Cellular biology --- Cytologists --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine
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Cell therapy --- Cell transplantation --- Cells--Therapeutic use --- Cells--Transplantation --- Cellulaire therapie --- Cellulaire transplantatie --- Cellular therapy --- Cellular transplantation --- Cellules--Transplantation --- Celtherapie --- Celtransplantatie --- Therapie [Cellulaire ] --- Therapy [Cellular ] --- Thérapie cellulaire --- Transplantatie [Cel] --- Transplantation cellulaire --- Cloning --- Fetus --- Clonage --- Foetus --- Research --- Therapeutic use --- Recherche --- Emploi en thérapeutique --- therapeutisch kloneren (therapeutisch klonen) --- clonage thérapeutique (clonage humain thérapeutique) --- Thérapie cellulaire --- Emploi en thérapeutique --- Cellules souches embryonnaires --- Transplantation --- Clone cells
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Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.
Blood -- Diseases. --- Hematopoietic stem cells -- Transplantation. --- Blood --- Hematopoietic stem cells --- Hemic and Lymphatic Diseases --- Transplantation --- Stem Cell Transplantation --- Hematologic Diseases --- Hematopoietic Stem Cell Transplantation --- Transplantation, Homologous --- Lymphatic Diseases --- Surgical Procedures, Operative --- Diseases --- Cell Transplantation --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Medicine --- Pathology --- Health & Biological Sciences --- Treatment --- Diseases. --- Transplantation. --- Clinical hematology --- Hematologic diseases --- Medicine. --- Hematology. --- Medicine & Public Health. --- Hematology --- Haematology --- Internal medicine
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The past decade has witnessed tremendous progress in the diagnostic and therapeutic approaches to malignant lymphoma as well as in understanding of the underlying molecular pathogenesis. Optimal treatment strategies are now based not only on accurate diagnosis but also on thorough evaluation of clinical and molecular risk factors. Even more importantly, molecular targeted approaches have been shown to be effective in the treatment of distinct lymphoma subtypes. Against this background, clinical management of especially the rare lymphomas remains a challenge for the general oncologist. This book provides a comprehensive overview of current treatment strategies in these rare lymphoma subtypes. Experts in the field from around the world describe the histomorphology in a clinically relevant manner, consider the role of risk factors in detail, and discuss the spectrum of therapeutic approaches. Special emphasis is placed on the translation of molecular science into clinical care, and a disease-specific algorithm is proposed for each entity. This book will prove an excellent resource for both experienced and inexperienced practitioners.
Lymphomas. --- Stem cells -- Transplantation. --- Lymphomas --- Disease Attributes --- Neoplasms by Histologic Type --- Neoplasms --- Pathologic Processes --- Pathological Conditions, Signs and Symptoms --- Diseases --- Lymphoma --- Rare Diseases --- Medicine --- Health & Biological Sciences --- Pathology --- Germinoblastomas --- Immunoblastomas --- Non-Hodgkin's lymphoma --- Reticulolymphosarcomas --- Sarcoma, Germinoblastic --- Sarcoma, Immunoblastic --- Medicine. --- Hematology. --- Oncology. --- Medicine & Public Health. --- Lymphoproliferative disorders --- Reticulo-endothelial system --- Tumors --- Oncology . --- Haematology --- Internal medicine --- Blood
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The fifth volume in the essential series on stem cell biology provides a detailed explanation of the mechanisms of self-renewing cancer stem cells, as well as their ability to generate the heterogeneous lineages of cancer cells that comprise tumors. It explores the unique resistance of cancer stem cells to conventional chemotherapy techniques able to kill a tumor’s constituent cells. The contents also include a discussion of the myriad applications of a selection of stem cells in treating disease and tissue injury. The cells singled out include human mesenchymal, arterial, neural, cardiac, dental, limbal, and hematopoietic stem cells. The therapeutic utility of uniquely adaptable human embryonic stem cells, able to generate any human cell type, is explored in depth. The volume looks at their uses in tissue engineering and regenerative medicine, as well as pharmacological, toxicological, and cell differentiation research. It also sheds light on the processes by which embryonic stem cells begin to differentiate by aggregating into more complex embryoid bodies. With additional material on targeting self-renewal pathways in cancer stem cells, the use of mesenchymal stem cells in treating ischemic brain injury, and the phenomenon of neural stem cell proliferation around traumatic brain injuries, this richly diverse and hugely informative book is a powerful tool for deepening professional expertise among researchers and practitioners in this field.
Cancer cells. --- Stem cells -- Therapeutic use. --- Stem cells -- Transplantation. --- Medicine --- Biology --- Health & Biological Sciences --- Oncology --- Cytology --- Medicine. --- Cancer research. --- Gene expression. --- Laboratory medicine. --- Neurosciences. --- Oncology. --- Pathology. --- Biomedicine. --- Cancer Research. --- Gene Expression. --- Laboratory Medicine. --- Medical laboratories. --- Oncology . --- Tumors --- Diagnosis, Laboratory --- Health facilities --- Laboratories --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Neural sciences --- Neurological sciences --- Neuroscience --- Nervous system --- Genes --- Genetic regulation --- Expression --- Clinical medicine --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Diagnosis --- Pathology --- Cancer research --- Stem cells.
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There have been major advances in understanding the behavior of stem cells and their roles in tissue regeneration, homeostasis and therapy. Cancer stem cell hypothesis opened a new opportunity for treating and preventing cancers by targeting cancer stem cells or cancer initiating cells. An increased understanding of stem cell behavior and biology along with rapid advancement of high throughput screening has led to the discovery and development of novel drugs that control stem cell self-renewal and differentiation. In near future, these molecules will be very useful for treating and preventing several human diseases. While progress on the clinical front has been slower than desired, the use of stem cells for tissue regeneration and disease management has great potential in human health. The first decade of the 21st century has brought with it significant progress in our understanding of stem cell or progenitor cells and their role in tissue regeneration and management of human diseases including cancer, neurodegenerative disorders, and heart diseases. This book covers the current state-of-the-art knowledge on the role of stem cells in tissue regeneration, homeostasis and disease management. Features: Coverage of the biology of stem cell and their role in tissue regeneration and organogenesis. Mechanism-based strategies for stem cell self-renewal and differentiation. Role of cancer stem cells or tumor initiating cells in cancer initiation, progression, relapse and drug resistance. Use of stem cells in treating several human diseases, such as Alzheimer’s disease, Parkinson’s disease, cancer and diabetes.
Cytology. --- Human diseases. --- Stem cells -- Transplantation. --- Stem cells. --- Diseases --- Cells --- Anatomy --- Stem Cells --- Neoplasms --- Biology --- Health & Biological Sciences --- Cytology --- Stem cells --- Research. --- Human beings --- Illness --- Illnesses --- Morbidity --- Sickness --- Sicknesses --- Medicine. --- Entomology. --- Literacy. --- Biomedicine. --- Biomedicine general. --- Medicine/Public Health, general. --- Medicine --- Epidemiology --- Health --- Pathology --- Sick --- Insects --- Zoology --- Illiteracy --- Education --- General education --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Health Workforce --- Biomedicine, general.
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Stem cell research has the potential to affect the lives of millions of people around the world. This research is now regularly front-page news, and realizing the promise of mesenchymal stem cells for yielding new medical therapies will require us to grapple with more than just scientific uncertainties. "Mesenchymal Stem Cells for the Heart - From Bench to Bedside" presents the cytobiological characteristics of mesenchymal stem cells from the isolation, culture, transmembrane ion currents, migration and differentiation in vitro to the repairing of injured myocardium and tissue reconstruction in vivo, including the results of basic research and the real possibility for treatments and ultimately for cures for cardiac diseases for which adequate therapies do not exist. The book is intended for clinical stem cell researchers in cardiovasology, hematology, cytobiology, molecular biology, cell and tissue engineering, and other related fields. Jian-an Wang, MD, PhD, Professor of Cardiology at Zhejiang University and investigator at Loma Linda University, Southern California, has broad expertise in the molecular and cellular biological processes underlying cardiovascular disease. He has won the Chinese Medical Science and Technology Medal of Honor.
Heart -- Diseases -- Treatment. --- Human cell culture. --- LinkMyocardium -- Regeneration. --- Stem cells -- Transplantation. --- Stem cells --- Heart --- Myocardium --- Transplantation. --- Diseases --- Treatment. --- Regeneration. --- Cardiac regeneration --- Stem cell transplantation --- Regeneration --- Engineering. --- Laboratory medicine. --- Cardiology. --- Biomedical engineering. --- Biomedical Engineering. --- Laboratory Medicine. --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Internal medicine --- Clinical medicine --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Diagnosis --- Pathology --- Construction --- Industrial arts --- Technology --- Cell transplantation --- Cell culture --- Medical laboratories. --- Biomedical Engineering and Bioengineering. --- Diagnosis, Laboratory --- Health facilities --- Laboratories
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Progenitor and stem cells have the ability to renew themselves and change into a variety of specialised types, making them ideal materials for therapy and regenerative medicine. Progenitor and stem cell technologies and therapies reviews the range of progenitor and stem cells available and their therapeutic application.Part one reviews basic principles for the culture of stem cells before discussing technologies for particular cell types. These include human embryonic, induced pluripotent, amniotic and placental, cord and multipotent stem cells. Part two discusses wider issues such as
Cellular therapy. --- Stem cells -- Therapeutic use. --- Stem cells -- Transplantation. --- Stem cells --- Cellular therapy --- Bone Marrow Cells --- Stem Cells --- Cell Transplantation --- Hematopoietic System --- Cells --- Transplantation --- Hemic and Immune Systems --- Anatomy --- Surgical Procedures, Operative --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Hematopoietic Stem Cells --- Stem Cell Transplantation --- Biology --- Health & Biological Sciences --- Cytology --- Therapeutic use --- Therapeutic use. --- Transplantation. --- Cell therapy --- Therapy, Cellular --- Organotherapy --- Therapeutics, Physiological --- Transplantation of organs, tissues, etc. --- Cell transplantation --- Stem cell transplantation --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells
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Hematopoietic Stem Cell Transplantation reviews pertinent aspects of both autologous and allogeneic stem cell transplantation and our current understanding of transplantation biology including T cell and natural killer cell biology, HLA expression, and post-transplant immune reconstitution. The unique aspect to this volume is that each chapter is co-authored by experts in their respective fields from different institutions to provide potentially different perspectives on each topic. This book provides a very current and succinct overview of hematopoietic stem cell transplantation that is complimentary to the larger texts on the field. "There have been dramatic advances in the application of hematopoietic stem cell transplantation for the treatment of malignant disease. This text provides a comprehensive update of the progress in the field. Technical and therapeutic innovations are reviewed by a distinguished assemblage of talented investigators." Steven T. Rosen, M.D., Series Editor.
Autotransplantation. --- Blood -- Diseases. --- Hematopoietic Stem Cell Transplantation. --- Hematopoietic stem cells -- Transplantation. --- Hematopoietic Stem Cell Transplantation --- Stem Cell Transplantation --- Cell Transplantation --- Transplantation --- Surgical Procedures, Operative --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Transplantation of Organs & Tissues --- Oncology --- Surgery & Anesthesiology --- Medicine --- Health & Biological Sciences --- Hematopoietic stem cells --- Bone marrow cells --- Transplantation. --- Marrow cells --- Medicine. --- Hematology. --- Oncology. --- Medicine & Public Health. --- Cells --- Oncology . --- Haematology --- Internal medicine --- Blood --- Tumors --- Diseases
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