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The enormous recent success of molecular developmental biology has yielded a vast amount of new information on the details of development. So much so that we risk losing sight of the underlying principles that apply to all development. To cut through this thicket, John Tyler Bonner ponders a moment in evolution when development was at its most basic--the moment when signaling between cells began. Although multicellularity arose numerous times, most of those events happened many millions of years ago. Many of the details of development that we see today, even in simple organisms, accrued over a long evolutionary timeline, and the initial events are obscured. The relatively uncomplicated and easy-to-grow cellular slime molds offer a unique opportunity to analyze development at a primitive stage and perhaps gain insight into how early multicellular development might have started. Through slime molds, Bonner seeks a picture of the first elements of communication between cells. He asks what we have learned by looking at their developmental biology, including recent advances in our molecular understanding of the process. He then asks what is the most elementary way that polarity and pattern formation can be achieved. To find the answer, he uses models, including mathematical ones, to generate insights into how cell-to-cell cooperation might have originated. Students and scholars in the blossoming field of the evolution of development, as well as evolutionary biologists generally, will be interested in what Bonner has to say about the origins of multicellular development--and thus of the astounding biological complexity we now observe--and how best to study it.

Cell interaction. --- Cells -- Evolution. --- Developmental biology. --- Developmental cytology. --- Cell Differentiation --- Signal Transduction --- Biological Evolution --- Genetic Processes --- Cell Physiological Processes --- Biochemical Processes --- Biological Processes --- Biochemical Phenomena --- Biological Phenomena --- Cell Physiological Phenomena --- Chemical Processes --- Genetic Phenomena --- Phenomena and Processes --- Chemical Phenomena --- Biophysics --- Biology --- Health & Biological Sciences --- Biologic Phenomena --- Biological Phenomenon --- Biological Process --- Phenomena, Biological --- Phenomena, Biologic --- Phenomenon, Biological --- Process, Biological --- Processes, Biological --- Biochemical Concepts --- Biochemical Phenomenon --- Biochemical Process --- Phenomena, Biochemical --- Biochemical Concept --- Concept, Biochemical --- Concepts, Biochemical --- Phenomenon, Biochemical --- Process, Biochemical --- Processes, Biochemical --- Molecular Biology --- Cell Physiological Phenomenon --- Cell Physiological Process --- Physiology, Cell --- Cell Physiology --- Phenomena, Cell Physiological --- Phenomenon, Cell Physiological --- Physiological Process, Cell --- Physiological Processes, Cell --- Process, Cell Physiological --- Processes, Cell Physiological --- Cells --- Genetic Concepts --- Genetic Phenomenon --- Genetic Process --- Concept, Genetic --- Concepts, Genetic --- Genetic Concept --- Phenomena, Genetic --- Phenomenon, Genetic --- Process, Genetic --- Processes, Genetic --- Evolution, Biological --- Sociobiology --- Receptor Mediated Signal Transduction --- Signal Transduction Pathways --- Signal Transduction Systems --- Cell Signaling --- Receptor-Mediated Signal Transduction --- Signal Pathways --- Pathway, Signal --- Pathway, Signal Transduction --- Pathways, Signal --- Pathways, Signal Transduction --- Receptor-Mediated Signal Transductions --- Signal Pathway --- Signal Transduction Pathway --- Signal Transduction System --- Signal Transduction, Receptor-Mediated --- Signal Transductions --- Signal Transductions, Receptor-Mediated --- System, Signal Transduction --- Systems, Signal Transduction --- Transduction, Signal --- Transductions, Signal --- Cell Communication --- Receptor-CD3 Complex, Antigen, T-Cell --- Receptor Cross-Talk --- Feedback, Physiological --- Gasotransmitters --- Differentiation, Cell --- Cell Differentiations --- Differentiations, Cell --- Embryo, Mammalian --- Gene Expression Regulation --- Cell Lineage --- Chemical Phenomenon --- Chemical Process --- Physical Chemistry Phenomena --- Physical Chemistry Process --- Physicochemical Phenomenon --- Physicochemical Process --- Chemical Concepts --- Physical Chemistry Concepts --- Physical Chemistry Processes --- Physicochemical Concepts --- Physicochemical Phenomena --- Physicochemical Processes --- Chemical Concept --- Chemistry Process, Physical --- Chemistry Processes, Physical --- Concept, Chemical --- Concept, Physical Chemistry --- Concept, Physicochemical --- Concepts, Chemical --- Concepts, Physical Chemistry --- Concepts, Physicochemical --- Phenomena, Chemical --- Phenomena, Physical Chemistry --- Phenomena, Physicochemical --- Phenomenon, Chemical --- Phenomenon, Physicochemical --- Physical Chemistry Concept --- Physicochemical Concept --- Process, Chemical --- Process, Physical Chemistry --- Process, Physicochemical --- Processes, Chemical --- Processes, Physical Chemistry --- Processes, Physicochemical --- physiology --- Cell interaction --- Developmental biology --- Developmental cytology --- 57.017.22 --- 575.853 --- Cell evolution --- Cellular evolution --- Evolution (Biology) --- Evolution --- 575.853 The cell and subcellular structure --- The cell and subcellular structure --- 57.017.22 Origin. Formation. Precursors --- Origin. Formation. Precursors --- Cytology --- Development (Biology) --- Growth --- Ontogeny --- Cell-cell interaction --- Cell communication --- Cellular communication (Biology) --- Cellular interaction --- Intercellular communication --- Cellular control mechanisms --- Signal Transduction. --- Biological Evolution. --- Cell Differentiation. --- Origin of Life. --- Genesis of Life --- Life Geneses --- Life Genesis --- Life Origin --- Life Origins --- Organelle Biogenesis --- Prebiotic Chemical Evolution --- Chemical Evolution, Prebiotic --- Evolution, Prebiotic Chemical --- Prebiotic Chemical Evolutions --- Evolution.