Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This volume explores detailed methods to investigate various aspects of biology related to cell polarity, or asymmetry within a cell. Molecular, cellular, and tissue-level regulation and function as well as diseases caused by impairment of cell polarity are explored by these methods. Beginning with advanced imaging and biochemical methods, the book continues with planar cell polarity (PCP) signaling in morphogenesis in diverse developmental contexts, apicobasal (AB) cell polarity in development and diseases, as well as directional cell migration and biomechanics in cell polarity. The collection includes the usage of a wide variety of model systems and an extensive array of techniques, including genetic, imaging, biochemical, and biomechanical. Written for the highly successful Methods in Molecular Biology format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Cell Polarity Signaling: Methods and Protocols aims to enable researchers to delve into the stimulating field of cell polarity and contribute to our understanding of how coordinated control of protein stability, trafficking, membrane retention, post-translational modification, and dynamic organization leads to active regulation of cell polarity. Chapter 29 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Cytology. --- Polarity (Biology). --- Cell Polarity. --- Cell Biology. --- Biology --- Tissues --- Cell biology --- Cellular biology --- Cells --- Polarity (Biology)

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Celdifferentiatie --- Cell differentiation --- Cellen--Differentiatie --- Cells--Differentiation --- Cellules epitheliales --- Cellules--Différentiation --- Differentiation of cells --- Differentitie [Cel] --- Différenciation cellulaire --- Epitheelcellen --- Epithelial cells --- Nerve-cells --- Neurocyte --- Neuronen --- Neurones --- Neurons --- Polariteit (Biologie) --- Polarity (Biology) --- Polarité (Biologie) --- -Epithelial cells --- -Cytology --- -Polarity (Biology) --- Epithelium --- Exfoliative cytology --- Cell Polarity --- Cytology --- Biology --- Tissues --- Cells --- Congresses --- Cell Differentiation --- Congresses. --- congresses. --- Cell polarity

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

“Symmetry Breaking in Cells and Tissues” presents a collection of seventeen reviews, opinions and original research papers contributed by theoreticians, physicists and mathematicians, as well as experimental biologists, united by a common interest in biological pattern formation and morphogenesis. The contributors discuss diverse manifestations of symmetry breaking in biology and showcase recent developments in experimental and theoretical approaches to biological morphogenesis and pattern formation on multiple scales.

actin waves --- curved proteins --- dynamic instability --- podosomes --- diffusion --- cell polarity --- Cdc42 --- stress --- cellular memory --- phase separation --- prions --- apoptotic extrusion --- oncogenic extrusion --- contractility --- actomyosin --- bottom-up synthetic biology --- motor proteins --- pattern formation --- self-organization --- cell motility --- signal transduction --- actin dynamics --- intracellular waves --- polarization --- direction sensing --- symmetry-breaking --- biphasic responses --- reaction-diffusion --- membrane and cortical tension --- cell fusion --- cortexillin --- cytokinesis --- Dictyostelium --- myosin --- symmetry breaking --- cytoplasmic flow --- phase-space analysis --- nonlinear waves --- actin polymerization --- bifurcation theory --- mass conservation --- spatial localization --- activator–inhibitor models --- developmental transitions --- cell polarization --- mathematical model --- fission yeast --- reaction–diffusion model --- small GTPases --- Cdc42 oscillations --- pseudopod --- Ras activation --- cytoskeleton --- chemotaxis --- neutrophils --- natural variation --- modelling --- activator-substrate mechanism --- mass-conserved models --- intracellular polarization --- partial differential equations --- sensitivity analysis --- GTPase activating protein (GAP) --- fission yeast Schizosaccharomyces pombe --- CRY2-CIBN --- optogenetics --- clustering --- positive feedback --- network evolution --- Saccharomyces cerevisiae --- polarity --- modularity --- neutrality --- n/a

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The arterial pole is one of the most complex parts of the heart both in development and disease. It involves the collaboration and orchestration of contributions from the first and second heart fields as well as the neural crest. The precursor cells differentiate into endocardial cushions and putative cardiac valves, the myocardium, and epicardium of the heart, but also into the different layers of the main arterial vessels. These include not only the aorta and the pulmonary trunk but also the pulmonary and coronary arteries, and during development, the arterial duct. Many transcriptional and signaling networks act in timely concert to acquire the proper asymmetric development and function and pressure and flow dynamics. This is not only a human or even mammalian ‘enterprise,’ but is also taking place in so-called ancestral forms from fish to reptiles, including birds. In humans, it is small wonder that many clinical syndromes may arise when something in this complexity is amiss. This Special Issue of JCDD contains contributions focussed on the heart fields, congenital cardiac malformations and associated syndromes, with special emphasis on the cardiac outflow tract. The Issue is devoted to Prof. Dr. Adriana Gittenberger-de Groot, who dedicated her extensive career to research on cardiovascular development.

Public health & preventive medicine --- transforming growth factor beta-3 --- cardiac development --- loeys dietz syndrome-5 --- arrhythmogenic right ventricular dysplasia --- rienhoff syndrome --- cleft palate --- congenital heart disease --- outflow tract septation --- signaling networks --- transcription factor AP-2α --- cardiovascular development --- outflow tract --- pharyngeal arch artery --- neural crest cell --- pharyngeal ectoderm --- Tetralogy of Fallot --- monozygotic twins --- discordant phenotype --- genetics --- variations --- epigenetics --- DNA methylation --- candidate genes --- acute aortic syndrome --- cardiovascular disease --- aorta --- aortic valve replacement --- surgical --- aortic surgery --- bicuspid aortic valve --- Bentall --- Kommerell’s diverticulum --- right sided aortic arch --- anomalous left subclavian artery --- arteria lusoria --- tracheal compression --- esophageal compression --- transposition great arteries coronary anatomy --- Rac1 --- proliferation --- cell polarity --- congenital heart defects --- compact myocardium --- trabeculation --- aortic stenosis --- asymptomatic --- early surgery --- watchful waiting --- cardiac progenitor cells --- second heart field --- neural crest --- endocardium --- cushion --- valve --- ductus arteriosus --- neointima --- tunica media --- transcriptome --- lineage tracing --- developmental biology --- cell identity --- atrioventricular valve --- epicardium --- lateral cushion --- major cushion --- myxomatous degeneration --- homograft --- semilunar valves --- aortic regurgitation --- superimposed tissue --- original leaflet --- myofibroblasts --- free edge folding --- remodeling --- dissection of ductus arteriosus --- sudden unexpected intrauterine death --- single coronary artery --- Leiden Convention coronary coding system --- Lipton classification --- coronary artery anatomy --- transposition of the great arteries --- arterial switch operation --- coronary artery --- coronary complications --- imaging --- fetal aortic stenosis --- prenatal ultrasound --- postmortem histology --- speckle tracking analysis --- endocardial fibro-elastosis --- endocardial cushions --- cartilage --- foramen of Panizza --- left aorta --- right aorta --- pulmonary trunk --- pharyngeal arch arteries --- coronary arteries --- cardiac fields --- cardiomyocyte --- progenitor specification --- heart tube --- aortic wall --- cardiovascular pathogenesis --- arterial duct

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The arterial pole is one of the most complex parts of the heart both in development and disease. It involves the collaboration and orchestration of contributions from the first and second heart fields as well as the neural crest. The precursor cells differentiate into endocardial cushions and putative cardiac valves, the myocardium, and epicardium of the heart, but also into the different layers of the main arterial vessels. These include not only the aorta and the pulmonary trunk but also the pulmonary and coronary arteries, and during development, the arterial duct. Many transcriptional and signaling networks act in timely concert to acquire the proper asymmetric development and function and pressure and flow dynamics. This is not only a human or even mammalian ‘enterprise,’ but is also taking place in so-called ancestral forms from fish to reptiles, including birds. In humans, it is small wonder that many clinical syndromes may arise when something in this complexity is amiss. This Special Issue of JCDD contains contributions focussed on the heart fields, congenital cardiac malformations and associated syndromes, with special emphasis on the cardiac outflow tract. The Issue is devoted to Prof. Dr. Adriana Gittenberger-de Groot, who dedicated her extensive career to research on cardiovascular development.

Public health & preventive medicine --- transforming growth factor beta-3 --- cardiac development --- loeys dietz syndrome-5 --- arrhythmogenic right ventricular dysplasia --- rienhoff syndrome --- cleft palate --- congenital heart disease --- outflow tract septation --- signaling networks --- transcription factor AP-2α --- cardiovascular development --- outflow tract --- pharyngeal arch artery --- neural crest cell --- pharyngeal ectoderm --- Tetralogy of Fallot --- monozygotic twins --- discordant phenotype --- genetics --- variations --- epigenetics --- DNA methylation --- candidate genes --- acute aortic syndrome --- cardiovascular disease --- aorta --- aortic valve replacement --- surgical --- aortic surgery --- bicuspid aortic valve --- Bentall --- Kommerell’s diverticulum --- right sided aortic arch --- anomalous left subclavian artery --- arteria lusoria --- tracheal compression --- esophageal compression --- transposition great arteries coronary anatomy --- Rac1 --- proliferation --- cell polarity --- congenital heart defects --- compact myocardium --- trabeculation --- aortic stenosis --- asymptomatic --- early surgery --- watchful waiting --- cardiac progenitor cells --- second heart field --- neural crest --- endocardium --- cushion --- valve --- ductus arteriosus --- neointima --- tunica media --- transcriptome --- lineage tracing --- developmental biology --- cell identity --- atrioventricular valve --- epicardium --- lateral cushion --- major cushion --- myxomatous degeneration --- homograft --- semilunar valves --- aortic regurgitation --- superimposed tissue --- original leaflet --- myofibroblasts --- free edge folding --- remodeling --- dissection of ductus arteriosus --- sudden unexpected intrauterine death --- single coronary artery --- Leiden Convention coronary coding system --- Lipton classification --- coronary artery anatomy --- transposition of the great arteries --- arterial switch operation --- coronary artery --- coronary complications --- imaging --- fetal aortic stenosis --- prenatal ultrasound --- postmortem histology --- speckle tracking analysis --- endocardial fibro-elastosis --- endocardial cushions --- cartilage --- foramen of Panizza --- left aorta --- right aorta --- pulmonary trunk --- pharyngeal arch arteries --- coronary arteries --- cardiac fields --- cardiomyocyte --- progenitor specification --- heart tube --- aortic wall --- cardiovascular pathogenesis --- arterial duct