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Gene expression regulation --- Genes, tumor suppressor --- Genes --- Transcription factors --- Cell cycle proteins --- biosynthesis

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How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences, gene organization? Are you tired of scanning review articles, primary papers and databases to locate that elusive fact? The Academic Press FactsBook series will satisfy scientists and clinical researchers suffering from information overload. Each volume provides a catalogue of the essential properties of families of molecules. Gene organization, amino acid sequences, physicochemical properties, and biological activity are presented using a common, easy to follow format. Taken together they compile everything you wanted to know about proteins but were too busy to look for. The Protein Kinase FactsBook: Protein - Tyrosine Kinases contains over 65 entries on members of the family from vertebrates, Drosophila, slime moulds and other organisms. Key Features * Entries provide information on: * Subunit structure and isoforms * Genetics * Sequence database accession numbers * Domain structures * Amino acid sequences * Homologues in other species * Patterns of expression * Physiological substrates and specificity determinants * Assays * Enzyme activators and inhibitors * References.

Enzymology --- Human biochemistry --- Protein kinases --- Protein Kinases. --- Handbooks, manuals, etc. --- Protein kinase --- Protein phosphotransferases --- Phosphotransferases --- Protein Kinase --- Kinase, Protein --- Kinases, Protein --- Cell Cycle Proteins --- Protein kinases.

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Genetics --- Human biochemistry --- Animal biochemistry --- Enzymology --- Molecular biology --- Calcium --- Nucleotides, Cyclic --- Phosphoproteins --- Cyclic nucleotides --- Phosphorylation --- Proteins --- Nucléotides cycliques --- Phosphoprotéines --- Protéines --- periodicals --- Physiological effect --- Periodicals --- Metabolism --- Effets physiologiques --- Périodiques --- Métabolisme --- Calcium. --- Nucleotides, Cyclic. --- Phosphoproteins. --- Protein Kinases --- #TS:KOMA --- Protein Kinase --- Kinase, Protein --- Kinases, Protein --- Cell Cycle Proteins --- Cyclic Nucleotides --- Blood Coagulation Factor IV --- Coagulation Factor IV --- Factor IV --- Factor IV, Coagulation --- Nucléotides cycliques --- Phosphoprotéines --- Protéines --- Périodiques --- Métabolisme --- MDBIOCHE --- periodicals. --- Calcium-40 --- Calcium 40 --- Periodicals. --- Phosphoprotein --- Cyclic Nucleotide --- Nucleotide, Cyclic

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Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress.   The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins).  These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity.  Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress.   Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus.  Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved.  .

Genes. --- Human molecular genetics --- Protein-protein interactions --- Cellular signal transduction --- Peptides --- Proteins --- Biological Science Disciplines --- Metabolic Phenomena --- Physiological Processes --- Natural Science Disciplines --- Physiological Phenomena --- Amino Acids, Peptides, and Proteins --- Phenomena and Processes --- Chemicals and Drugs --- Disciplines and Occupations --- Stress, Physiological --- Cell Cycle Proteins --- Intracellular Signaling Peptides and Proteins --- Metabolism --- Physiology --- Medicine --- Biology --- Health & Biological Sciences --- Pathology --- Genetics --- Medicine. --- Human genetics. --- Medical genetics. --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Clinical genetics --- Diseases --- Heredity of disease --- Clinical sciences --- Medical profession --- Composition --- Genetic aspects --- Biomedicine. --- Gene Function. --- Biochemistry, general. --- Human Genetics. --- Chemistry --- Medical sciences --- Human genetics --- Genetic disorders --- Heredity, Human --- Human biology --- Physical anthropology --- Life sciences --- Physicians

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Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during development as well as in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role that Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may have therapeutic potential for the treatment of a number of neurodegenerative diseases.

Biomedicine. --- Neurosciences. --- Cell Biology. --- Developmental Biology. --- Medicine. --- Cytology. --- Developmental biology. --- Médecine --- Neurosciences --- Cytologie --- Biologie du développement --- Cyclin-Dependent Kinases -- antagonists and inhibitors. --- Cyclin-dependent kinases -- Inhibitors -- Therapeutic use. --- Cyclin-Dependent Kinases -- therapeutic use. --- Cyclin-dependent kinases. --- Nervous system -- Degeneration -- Etiology. --- Nervous system -- Degeneration -- Treatment. --- Neurodegenerative Diseases -- drug therapy. --- Nervous System Diseases --- Cell Cycle Proteins --- Proline-Directed Protein Kinases --- Intracellular Signaling Peptides and Proteins --- Protein-Serine-Threonine Kinases --- Proteins --- Diseases --- Peptides --- Protein Kinases --- Phosphotransferases (Alcohol Group Acceptor) --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Phosphotransferases --- Transferases --- Enzymes --- Enzymes and Coenzymes --- Cyclin-Dependent Kinases --- Neurodegenerative Diseases --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Animal Biochemistry --- Neurology --- Cyclin-dependent kinases --- Nervous system --- Inhibitors --- Therapeutic use. --- Degeneration --- Etiology. --- Treatment. --- CDK proteins --- Cyclin-dependent protein kinases --- Cell biology. --- Organs (Anatomy) --- Protein kinases --- Development (Biology) --- Biology --- Growth --- Ontogeny --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences