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The completion of the Human Genome Project and the rapid progress in cell biology and biochemical engineering, are major forces driving the steady increase of approved biotech products, especially biopharmaceuticals, in the market. Today mammalian cell products (“products from cells”), primarily monoclonals, cytokines, recombinant glycoproteins, and, increasingly, vaccines, dominate the biopharmaceutical industry. Moreover, a small number of products consisting of in vitro cultivated cells (“cells as product”) for regenerative medicine have also been introduced in the market. Their efficient production requires comprehensive knowledge of biological as well as biochemical mammalian cell culture fundamentals (e.g., cell characteristics and metabolism, cell line establishment, culture medium optimization) and related engineering principles (e.g., bioreactor design, process scale-up and optimization). In addition, new developments focusing on cell line development, animal-free culture media, disposables and the implications of changing processes (multi-purpose- facilities) have to be taken into account. While a number of excellent books treating the basic methods and applications of mammalian cell culture technology have been published, only little attention has been afforded to their engineering aspects. The aim of this book is to make a contribution to closing this gap; it particularly focuses on the interactions between biological and biochemical and engineering principles in processes derived from cell cultures. It is not intended to give a comprehensive overview of the literature. This has been done extensively elsewhere.

Cell culture -- Industrial applications. --- Cell Culture Techniques. --- Cells. --- Cytological Techniques. --- Genetic Techniques. --- Mammals -- Cytology -- Technique. --- Medical informatics. --- Molecular Biology. --- Tissue engineering. --- Tissue engineering --- Culture Techniques --- Clinical Laboratory Techniques --- Investigative Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Tissue Engineering --- Biology --- Health & Biological Sciences --- Cytology --- Biomedical Engineering --- Life sciences. --- Pharmaceutical technology. --- Biotechnology. --- Biochemical engineering. --- Cell biology. --- Cell culture. --- Biomedical engineering. --- Life Sciences. --- Cell Culture. --- Biochemical Engineering. --- Biomedical Engineering. --- Pharmaceutical Sciences/Technology. --- Cell Biology. --- Biomedical engineering --- Regenerative medicine --- Tissue culture --- Cytology. --- Biomedical Engineering and Bioengineering. --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Chemical engineering --- Genetic engineering --- Bio-process engineering --- Bioprocess engineering --- Biochemistry --- Biotechnology --- Cultures (Biology) --- Technique --- Pharmaceutical chemistry. --- Chemical Bioengineering. --- Pharmaceutics. --- Technique. --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Chemistry