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Cell adhesion --- Cellules --- Adhésivité --- Cell adhesion. --- 576.52 --- Adherence, Cell --- Cell adherence --- Adhesion --- Cell interaction --- Membrane fusion --- Junctional complexes (Epithelium) --- Phenomena at cell surfaces. Cell adhesion. Cell contacts --- 576.52 Phenomena at cell surfaces. Cell adhesion. Cell contacts --- Adhésivité

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Adhesive Interactions in Normal and Transformed Cells describes the basic mechanisms of the ability of tissue cells to attach to each other and to the extracellular matrix. These adhesive interactions are pivotal regulators of main cellular functions, such as proliferation, survival and migration. The adhesive interactions are involved in embryonic development, regeneration, and also in inflammation and degeneration processes, which are at the basis of many diseases. Serious alterations in cell adhesion caused by the oncogenic transformation play a key role in cancer invasion and metastasis. This volume provides comprehensive information about structural, mechanistic and signaling aspects of adhesive interactions in both normal and cancer cells in comparison. Integration of such aspects of the adhesive process as structure, relation to cell systems of receptors and cytoskeleton, function, signaling pathways, and the alterations in tumor cells constitutes the strongest point of this work. The results of the long-time author’s research are included in the book. The author was one of pioneers, who used scanning electron microscopy (SEM) to study the cell surface morphology of normal cultured cells and the cells underwent the oncogenic transformation, processes of their attachment to and spreading on the surfaces of a solid substratum, and also surprising ability of the cells to respond to various geometric configurations of the substrata surfaces.  Adhesive Interactions in Normal and Transformed Cells has both biological and medical aspects and, therefore, it can be interesting not only for cell biologists, developmental biologists and cancer researchers, but also for physicians. It is intended for researchers, postdocs, undergraduate and graduate students.

Cell adhesion. --- Cell adhesion --- Cell Physiological Processes --- Cell Physiological Phenomena --- Phenomena and Processes --- Cell Adhesion --- Biology --- Health & Biological Sciences --- Biology - General --- Cytology --- Adherence, Cell --- Cell adherence --- Life sciences. --- Cancer research. --- Cell physiology. --- Life Sciences. --- Life Sciences, general. --- Cancer Research. --- Cell Physiology. --- Adhesion --- Cell interaction --- Membrane fusion --- Junctional complexes (Epithelium) --- Oncology. --- Cell function --- Physiology --- Tumors --- Biosciences --- Sciences, Life --- Science --- Cancer research

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Integrins are heterodimeric cell surface receptors which anchor cells to different extracellular matrix proteins or act as cell-cell receptors. They play pivotal roles not only across a wide range of physiological processes including tissue morphogenesis, wound healing, and regulation of cell growth, but also in numerous pathological conditions such as autoimmunity, infectious disease, and carcinogenesis. This book aims to provide readers a summary of the most important integrins and their respective biological functions. Readers will learn about knockout- and animal models to study the functionality of key collagen-, laminin-, and nephronectin-binding integrins. Additionally, the role of integrins in pathological tissue remodeling in joints and in developing and diseased cardiac tissue are discussed. Reviews of the current knowledge of the role of integrins in tissue and tumor fibrosis, angiogenesis and tumor progression are an important part of this work. Finally, the book discusses integrins in the context of the immune system, how to target integrin-ligand interactions with antibodies, and the role of integrins as receptors for bacterial and viral cell invasion. Both experienced researchers and clinicians, as well as PhD students who wish to study the extracellular matrix and cell adhesion molecules will find “Integrins in Health and Disease - Key Effectors of Cell-Matrix and Cell-Cell Interactions” authoritative, easily accessible, and vastly informative. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.

Cell adhesion. --- Cytology. --- Proteins. --- Cell Adhesion. --- Cell Biology. --- Protein Biochemistry. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Cell biology --- Cellular biology --- Biology --- Cells --- Adherence, Cell --- Cell adherence --- Adhesion --- Cell interaction --- Membrane fusion --- Junctional complexes (Epithelium) --- Integrins. --- Cell adhesion protein receptors --- Cell adhesion molecules --- Glycoproteins

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Cell Adhesion Molecules --- Cell Adhesion --- Endothelium --- Inflammation --- Leukocytes --- Cell adhesion --- Cell adhesion molecules --- -Inflammatory process --- Pathology --- Anti-inflammatory agents --- Adhesion molecules (Cytology) --- Adhesion substances (Cytology) --- Cell adhesion substances --- Intercellular adhesion molecules --- Morphoregulatory molecules --- Biomolecules --- Desmosomes --- Hemidesmosomes --- Adherence, Cell --- Cell adherence --- Adhesion --- Cell interaction --- Membrane fusion --- Junctional complexes (Epithelium) --- physiology. --- physiopathology. --- Pathophysiology --- Cell adhesion molecules. --- Cell adhesion. --- CELL ADHESION MOLECULES --- CELL ADHESION --- ENDOTHELIUM --- INFLAMMATION --- Pathophysiology. --- physiology --- physiopathology --- -physiology. --- Physiology. --- Physiopathology. --- Inflammatory process

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This book acts as a field-guide for human cells. The book’s unique structure first separates cells by what makes them distinctive, and then examines the essential “tools and parts” needed for both the cells’ specialized function, and also the basic mechanisms that are shared with most other cells. The chapters highlight interactions between multiple cell types, exploring areas such as immunology and cancer to exemplify the complex coordination of cells, and the manipulation of normal cell interactions. This book works as a companion reference for an academic text in cell and molecular science, and will be of general interest to anyone who wants to learn more about how cells work and interact. .

Anatomy. --- Cytology. --- Cells. --- Cell adhesion. --- Cell Division. --- Cytoskeleton. --- Biophysics. --- Cell interaction. --- Cell Types. --- Cell Biology. --- Cell Adhesion. --- Mechanobiological Cell Signaling. --- Cell-cell interaction --- Cell communication --- Cellular communication (Biology) --- Cellular interaction --- Intercellular communication --- Cellular control mechanisms --- Biological physics --- Biology --- Medical sciences --- Physics --- Cell skeleton --- Skeleton, Cell --- Cytoplasm --- Division of cells --- Cell proliferation --- Adherence, Cell --- Cell adherence --- Adhesion --- Cell interaction --- Membrane fusion --- Junctional complexes (Epithelium) --- Organisms --- Cytology --- Cell biology --- Cellular biology --- Cells --- Animal anatomy --- Animals --- Physiology --- Anatomy