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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

cell adhesion molecule --- extracellular matrix --- immune system --- cancer progression --- cytoskeleton --- cell dynamics

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Anemia, Sickle Cell --- Erythropoiesis. --- Vascular Cell Adhesion Molecule-1 --- Severity of Illness Index. --- Acenocoumarol --- Illness Index Severities --- Illness Index Severity --- Index Severities, Illness --- Index Severity, Illness --- Erythropoieses --- drug therapy. --- blood. --- administration & dosage. --- Theses --- Disease Severity --- Disease Severities --- Severity, Disease --- Erythropoiesis --- Severity of Illness Index --- drug therapy --- blood --- administration & dosage

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The cancer stem cell (CSC) paradigm represents one of the most prominent breakthroughs of the last decades in tumor biology. CSCs are that subpopulation within a tumor that can survive conventional therapies and as a consequence are able to fuel tumor recurrence. Nevertheless, the biological characteristics of CSCs and even their existence, remain the main topic among tumor biologists debates. The difficulty in achieving a better definition of CSC biology may actually be explained by the plasticity of such a cell subpopulation. Indeed, the emerging view is that CSCs represent a dynamic “state” of tumor cells that can acquire stemness-related properties under specific circumstances, rather than referring to a well-defined group of cells. Regardless of their origin, it is clear that designing novel antitumor treatments based on the eradication of CSCs will only be possible upon unraveling the biological mechanisms that underlie their pathogenic role in tumor progression and therapy resistance. The Special Issue on “New aspects of cancer stem cell biology: implications for innovative therapies” aims at highlighting recent insights into CSC features that can make them an attractive target for novel therapeutic strategies.

Research & information: general --- Biology, life sciences --- Cadherin 11 --- WNT signaling --- β-catenin --- cancer stem cells --- TNBC --- early breast cancer --- bevacizumab --- neoadjuvant chemotherapy --- ALDH1 --- solid cancer --- chemo-resistance --- HDAC inhibitors --- head and neck squamous cell carcinoma --- SRC --- dasatinib --- saracatinib --- EC-8042 --- Ovarian cancer --- Wnt signaling --- tumor progression --- therapy resistance --- exosomes --- oral cancer risk --- oral epithelial dysplasia --- SOX2 --- immunohistochemistry --- oral squamous cell carcinoma --- genome-wide --- transcriptome --- lung cancer --- ATAC-seq --- RNA-seq --- CSCs --- NSCLC --- B4GALT1 --- LUAD --- breast cancer --- lipid --- metabolism --- therapeutic resistance --- bowel cancer --- organoid --- tumoroid --- colorectal --- colon --- stem cell --- chemotherapy resistance --- ovarian cancer --- cancer stem cell --- genetic heterogeneity --- SNP array --- L1CAM --- chemoresistance --- epithelial-mesenchymal transition --- cancer therapy --- cell adhesion molecule

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Immunology. Immunopathology --- HLA histocompatibility antigens --- Antigens, CD --- Cell Adhesion Molecules --- Handbooks, manuals, etc --- Antigens, CD. --- Cell Adhesion Molecules. --- -616-097 --- 577.27 --- HL-A histocompatibility antigens --- HLA antigens --- HLA transplantation antigens --- Human leukocyte antigens --- Transplantation antigens, Human --- Histocompatibility antigens --- Major histocompatibility complex --- Saccharide Mediated Cell Adhesion Molecules --- Intercellular Adhesion Molecules --- Leukocyte Adhesion Molecules --- Saccharide-Mediated Cell Adhesion Molecules --- Adhesion Molecules, Cell --- Adhesion Molecules, Intercellular --- Adhesion Molecules, Leukocyte --- Molecules, Cell Adhesion --- Molecules, Intercellular Adhesion --- Molecules, Leukocyte Adhesion --- Integrins --- Cluster of Differentiation Antigens --- Cluster of Differentiation Markers --- Differentiation Antigens, Leukocyte, Human --- Leukocyte Differentiation Antigens, Human --- CD Antigens --- Antigens. Antibodies --- Molecular bases of immunity. Molecular immunology --- Antigens. --- CD antigens --- HLA Antigens --- Handbooks, manuals, etc. --- handbooks. --- 577.27 Molecular bases of immunity. Molecular immunology --- 616-097 Antigens. Antibodies --- Antigens, cd --- Cd antigens --- Hla antigens --- Hla histocompatibility antigens --- Handbooks. --- 616-097 --- CD glycoproteins --- CD molecules --- CD receptors --- CD surface immunoglobulin ligands --- Differentiation antigens, Human leukocyte --- Human leukocyte differentiation antigens --- Leukocyte differentiation antigens, Human --- Cell surface antigens --- Fc receptors --- Glycoproteins --- LEUCOCYTES --- Monograph --- Leucocytes. --- Leukocytes --- White blood cells --- White cells --- Blood cells --- Killer cells --- Cell Adhesion Molecule --- Intercellular Adhesion Molecule --- Leukocyte Adhesion Molecule --- Adhesion Molecule, Cell --- Adhesion Molecule, Intercellular --- Adhesion Molecule, Leukocyte --- Molecule, Cell Adhesion --- Molecule, Intercellular Adhesion --- Molecule, Leukocyte Adhesion --- CD Antigen --- Cluster of Differentiation Antigen --- Cluster of Differentiation Marker --- Antigen Cluster, Differentiation --- Antigen, CD --- Differentiation Antigen Cluster --- Differentiation Marker Cluster --- Marker Cluster, Differentiation

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The book is a collection of original research and review articles addressing the intriguing field of the cellular and molecular players involved in muscle homeostasis and regeneration. One of the most ambitious aspirations of modern medical science is the possibility of regenerating any damaged part of the body, including skeletal muscle. This desire has prompted clinicians and researchers to search for innovative technologies aimed at replacing organs and tissues that are compromised. In this context, the papers, collected in this book, addressing a specific aspects of muscle homeostasis and regeneration under physiopathologic conditions, will help us to better understand the underlying mechanisms of muscle healing and will help to design more appropriate therapeutic approaches to improve muscle regeneration and to counteract muscle diseases.

lysine --- mTORC1 --- satellite cells --- proliferation --- skeletal muscle growth --- muscle satellite cell --- transthyretin --- thyroid hormone --- myogenesis --- exosomes --- skeletal muscle --- genotype --- genetic variation --- muscle phenotypes --- sarcopenia --- aging --- calcium homeostasis --- hibernation --- mitochondria --- sarcoplasmic reticulum --- Acvr1b --- Tgfbr1 --- myostatin --- Col1a1 --- fibrosis --- atrophy --- IGF2R --- muscle homeostasis --- inflammation --- muscular dystrophy --- pericytes --- macrophages --- Nfix --- phagocytosis --- RhoA-ROCK1 --- splicing isoforms --- CRISPR-Cas9 --- exon deletion --- NF-Y --- muscle differentiation --- C2C12 cells --- denervation --- neuromuscular junction --- heavy resistance exercise --- acetylcholine receptor --- cell culture --- neonatal myosin --- neural cell adhesion molecule --- biomarkers --- mitophagy --- mitochondrial dynamics --- mitochondrial quality control --- mitochondrial-derived vesicles (MDVs) --- mitochondrial-lysosomal axis --- Hibernation --- electron microscopy --- immunocytochemistry --- α-smooth muscle actin --- confocal microscopy --- connexin 43 --- connexin 26 --- gap junctions --- myofibroblasts --- Platelet-Rich Plasma --- transforming growth factor (TGF)-β1 --- muscle regeneration --- inflammatory response --- cell precursors --- experimental methods --- stem cell markers --- muscles --- heterotopic ossification --- skeletal muscle stem and progenitor cells --- HO precursors --- muscle atrophy --- septicemia --- mitochondrial fusion --- mitochondrial fission --- iPSC --- extracellular vesicles --- Drosophila --- muscle --- genetic control --- muscle diversification --- fascicle --- myofiber --- myofibril --- sarcomere --- hypertrophy --- hyperplasia --- splitting --- radial growth --- longitudinal growth --- exercise --- muscle stem cells --- stem cells niche --- neuromuscular disorders --- Duchenne muscular dystrophy --- pharmacological approach --- single-cell --- mass cytometry --- skeletal muscle regeneration --- skeletal muscle homeostasis --- fibro/adipogenic progenitors --- myogenic progenitors --- muscle populations --- evolution --- metazoans --- differentiation --- transdifferentiation --- muscle precursors --- regenerative medicine --- stem cells --- FAPs --- tissue niche --- growth factors --- muscle pathology