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Heart Failure --- Caveolae --- Muscle, Smooth, Vascular --- physiopathology --- metabolism

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

microdomain --- cardiomyocte --- caveolae --- t-tubule --- L-type Ca channel --- intercalated disc --- Na channel

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Biological membranes protect cells and organelles from the surrounding environment, but serve also as organising platforms for physiological processes such as cell signalling. The hydrophobic core of membranes is composed of lipids and proteins influencing each other. Local membrane composition and properties define its molecular organisation and, in this way, regulate the function of all associated molecules. Therefore, studying interactions of components, biophysical properties and overall membrane dynamics provides essential information on its function in the context of cell activities. Such knowledge can contribute to biomedical fields such as pharmacology, immunology, neurobiology and many others. The goal of the Research Topic entitled ‘Molecular organisation of membranes: where biology meets biophysics’ was to provide a comprehensive platform for publishing articles, reviews and opinions focused on membrane organisation and the forces behind its heterogeneous and dynamic structure. We collected 11 works which cover topics as diverse as general membrane organisation models, membrane trafficking and signalling regulation, biogenesis of caveolae, protein-lipid interactions and the importance of membrane-associated tetraspanins networks. The prevalent theme was the existence of membrane nanodomains. To this point, new emerging technologies are presented which own the power to bring a novel insight on how membrane nanodomains are formed and maintained and what is their function. We believe that the collection of works in this Research Topic brings forward some important questions which will stimulate further research in this difficult but exciting field.

Cell Membrane --- Caveolae --- Superresolution microscopy --- Nanodomains --- Membrane trafficking --- Membrane properties --- fluorescence microscopy --- Tetraspanins

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Science: general issues --- Physiology --- microdomain --- cardiomyocte --- caveolae --- t-tubule --- L-type Ca channel --- intercalated disc --- Na channel

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For more than a decade, caveolin proteins have attracted a lot of attention in the field of cancer research. Additional roles besides maintaining the structural integrity of caveolae (meaning “little caves” in latin) have been attributed to these complex proteins. In fact, they have emerged as important regulators of cell signaling, proliferation, invasion and angiogenesis. The current book focuses on caveolin-1, the best-studied and well- characterized of all three caveolin family members (caveolin-1, -2 and -3). As such, the current chapters illustrate the roles of caveolin-1 in breast, prostate, skin, colon, brain and pancreatic cancers, and highlight its specific contribution to tumor growth through epithelial and stromal interactions, as well as its involvement in angiogenesis. This book summarizes the existing literature and provides interesting new perspectives on future advancement and therapeutic possibilities involving caveolins in cancer. This work brings together highly respected and experienced scientists in the field of caveolins who wrote informative chapters on the role of caveolin-1 in cancer in a format that conveys its role as both a tumor suppressor and tumor promoter. We invite you to read, enjoy and be part of these new promising discoveries that are rapidly advancing the field of cancer research.

Carcinogenesis. --- Carcinogenesis --- Adaptor Proteins, Signal Transducing --- Diseases --- Phosphoproteins --- Biological Markers --- Coated Pits, Cell-Membrane --- Membrane Microdomains --- Metabolic Phenomena --- Biological Science Disciplines --- Caveolins --- Biochemical Processes --- Medicine --- Coated Vesicles --- Cell Physiological Processes --- Health Occupations --- Intracellular Signaling Peptides and Proteins --- Carrier Proteins --- Phenomena and Processes --- Transport Vesicles --- Chemical Processes --- Biological Factors --- Cell Membrane Structures --- Vesicular Transport Proteins --- Cell Physiological Phenomena --- Natural Science Disciplines --- Biochemical Phenomena --- Proteins --- Chemical Phenomena --- Amino Acids, Peptides, and Proteins --- Disciplines and Occupations --- Chemicals and Drugs --- Cytoplasmic Vesicles --- Cell Membrane --- Membrane Proteins --- Peptides --- Cellular Structures --- Organelles --- Cells --- Cytoplasmic Structures --- Anatomy --- Cytoplasm --- Intracellular Space --- Caveolin 1 --- Caveolae --- Metabolism --- Physiology --- Signal Transduction --- Neoplasms --- Tumor Markers, Biological --- Pathology --- Health & Biological Sciences --- Oncology --- Cancer --- Prevention. --- Treatment. --- Cancer therapy --- Cancer treatment --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Therapy --- Pathogenesis --- Medicine. --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Genetic toxicology --- Oncology. --- Toxicology. --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Tumors --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Cancer research --- Physiological effect